BMP-regulated exosomes from Drosophila male reproductive glands reprogram female behavior.
Bottom Line: Male reproductive glands secrete signals into seminal fluid to facilitate reproductive success.Exosome release was required to inhibit female remating behavior, suggesting that exosomes are downstream effectors of BMP signaling.These results demonstrate a new function for the MVB-exosome pathway in the reproductive tract that appears to be conserved across evolution.
Affiliation: Department of Physiology, Anatomy and Genetics and Nuffield Department of Surgical Sciences, University of Oxford, Oxford OX1 3QX, England, UK.Show MeSH
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Mentions: Strikingly, real-time confocal imaging of SCs revealed nonacidic SVs fusing with mMVBLs and rapid exchange of limiting membrane components (Fig. 4 A and Video 1). Although the internal contents of these compartments did not mix freely, these findings suggest a surprising level of exchange between SVs and mMVBLs and might explain how CD63-GFP–positive structures accumulate in SVs (Fig. 1, E–H).
Affiliation: Department of Physiology, Anatomy and Genetics and Nuffield Department of Surgical Sciences, University of Oxford, Oxford OX1 3QX, England, UK.