Buffered Qualitative Stability explains the robustness and evolvability of transcriptional networks.
Bottom Line: The gene regulatory network (GRN) is the central decision-making module of the cell.BQS explains many of the small- and large-scale properties of GRNs, provides conditions for evolvable robustness, and highlights general features of transcriptional response.BQS is severely compromised in a human cancer cell line, suggesting that loss of BQS might underlie the phenotypic plasticity of cancer cells, and highlighting a possible sequence of GRN alterations concomitant with cancer initiation.
Affiliation: College of Life Sciences, University of Dundee, Dundee, United Kingdom firstname.lastname@example.org.Show MeSH
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Mentions: P. aeruginosa has no long (>3 genes) feedback loops, and of its seven 2-node feedback loops five are isolated, and so are either stable or likely to act as switches, whilst the other two are linked but are of a form (positive-negative) that makes them Qualitatively Stable. Both of the S. cerevisiae 2-node feedback loops are isolated, whilst the human GM12878 cell line has only a single 2-node feedback loop which is therefore isolated. Curiously, the only long feedback loop observed in the yeast GRN derived by Lee et al. (2002) presents the same potentially chaotic topology discussed above. However, this illegal motif is not present in the more recent GRN derived by Harbison et al. (2004) (Figure 6—figure supplement 3).
Affiliation: College of Life Sciences, University of Dundee, Dundee, United Kingdom email@example.com.