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Buffered Qualitative Stability explains the robustness and evolvability of transcriptional networks.

Albergante L, Blow JJ, Newman TJ - Elife (2014)

Bottom Line: The gene regulatory network (GRN) is the central decision-making module of the cell.BQS explains many of the small- and large-scale properties of GRNs, provides conditions for evolvable robustness, and highlights general features of transcriptional response.BQS is severely compromised in a human cancer cell line, suggesting that loss of BQS might underlie the phenotypic plasticity of cancer cells, and highlighting a possible sequence of GRN alterations concomitant with cancer initiation.

View Article: PubMed Central - PubMed

Affiliation: College of Life Sciences, University of Dundee, Dundee, United Kingdom l.albergante@dundee.ac.uk.

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Long feedback loops in M. tuberculosis.Only three long feedback loops are observed in M. tuberculosis (A–C). Note the presence of the same 3-node motifs observed in E. coli (Figure 6A,B) and how these two motifs are entangled in the four node feedback loop (C).DOI:http://dx.doi.org/10.7554/eLife.02863.027
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fig6s2: Long feedback loops in M. tuberculosis.Only three long feedback loops are observed in M. tuberculosis (A–C). Note the presence of the same 3-node motifs observed in E. coli (Figure 6A,B) and how these two motifs are entangled in the four node feedback loop (C).DOI:http://dx.doi.org/10.7554/eLife.02863.027

Mentions: These ideas are also supported by the M. tuberculosis GRN: all the four genes involved in the formation of illegal motifs are implicated in stress responses (He et al., 2006; Rodriguez et al., 2002), and the two 3-gene feedback loops share the same topology observed in E. coli (Figure 6—figure supplement 2A,B). In addition, of the six 2-node feedback loops observed in the M. tuberculosis GRN, three are isolated from other feedback loops and the other three are embedded into the two potentially chaotic motifs. Finally, it is noteworthy that the 4-gene feedback loop in the M. tuberculosis GRN is formed by joining the two 3-gene feedback loops (Figure 6—figure supplement 2C), consistent with our earlier observation that long feedback loops are susceptible to the formation of additional embedded feedback loops.


Buffered Qualitative Stability explains the robustness and evolvability of transcriptional networks.

Albergante L, Blow JJ, Newman TJ - Elife (2014)

Long feedback loops in M. tuberculosis.Only three long feedback loops are observed in M. tuberculosis (A–C). Note the presence of the same 3-node motifs observed in E. coli (Figure 6A,B) and how these two motifs are entangled in the four node feedback loop (C).DOI:http://dx.doi.org/10.7554/eLife.02863.027
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4151086&req=5

fig6s2: Long feedback loops in M. tuberculosis.Only three long feedback loops are observed in M. tuberculosis (A–C). Note the presence of the same 3-node motifs observed in E. coli (Figure 6A,B) and how these two motifs are entangled in the four node feedback loop (C).DOI:http://dx.doi.org/10.7554/eLife.02863.027
Mentions: These ideas are also supported by the M. tuberculosis GRN: all the four genes involved in the formation of illegal motifs are implicated in stress responses (He et al., 2006; Rodriguez et al., 2002), and the two 3-gene feedback loops share the same topology observed in E. coli (Figure 6—figure supplement 2A,B). In addition, of the six 2-node feedback loops observed in the M. tuberculosis GRN, three are isolated from other feedback loops and the other three are embedded into the two potentially chaotic motifs. Finally, it is noteworthy that the 4-gene feedback loop in the M. tuberculosis GRN is formed by joining the two 3-gene feedback loops (Figure 6—figure supplement 2C), consistent with our earlier observation that long feedback loops are susceptible to the formation of additional embedded feedback loops.

Bottom Line: The gene regulatory network (GRN) is the central decision-making module of the cell.BQS explains many of the small- and large-scale properties of GRNs, provides conditions for evolvable robustness, and highlights general features of transcriptional response.BQS is severely compromised in a human cancer cell line, suggesting that loss of BQS might underlie the phenotypic plasticity of cancer cells, and highlighting a possible sequence of GRN alterations concomitant with cancer initiation.

View Article: PubMed Central - PubMed

Affiliation: College of Life Sciences, University of Dundee, Dundee, United Kingdom l.albergante@dundee.ac.uk.

Show MeSH
Related in: MedlinePlus