Buffered Qualitative Stability explains the robustness and evolvability of transcriptional networks.
Bottom Line: The gene regulatory network (GRN) is the central decision-making module of the cell.BQS explains many of the small- and large-scale properties of GRNs, provides conditions for evolvable robustness, and highlights general features of transcriptional response.BQS is severely compromised in a human cancer cell line, suggesting that loss of BQS might underlie the phenotypic plasticity of cancer cells, and highlighting a possible sequence of GRN alterations concomitant with cancer initiation.
Affiliation: College of Life Sciences, University of Dundee, Dundee, United Kingdom email@example.com.Show MeSH
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Mentions: These ideas are also supported by the M. tuberculosis GRN: all the four genes involved in the formation of illegal motifs are implicated in stress responses (He et al., 2006; Rodriguez et al., 2002), and the two 3-gene feedback loops share the same topology observed in E. coli (Figure 6—figure supplement 2A,B). In addition, of the six 2-node feedback loops observed in the M. tuberculosis GRN, three are isolated from other feedback loops and the other three are embedded into the two potentially chaotic motifs. Finally, it is noteworthy that the 4-gene feedback loop in the M. tuberculosis GRN is formed by joining the two 3-gene feedback loops (Figure 6—figure supplement 2C), consistent with our earlier observation that long feedback loops are susceptible to the formation of additional embedded feedback loops.
Affiliation: College of Life Sciences, University of Dundee, Dundee, United Kingdom firstname.lastname@example.org.