Limits...
Grouping of Experimental Conditions as an Approach to Evaluate Effects of Extremely Low-Frequency Magnetic Fields on Oxidative Response in in vitro Studies.

Mattsson MO, Simkó M - Front Public Health (2014)

Bottom Line: A large body of literature deals with biological effects of extremely low-frequency magnetic fields (ELF MFs) studied in vitro.Despite the multitude of studies, no coherent picture has evolved regarding the plausibility of effects at low-flux densities or regarding the interaction mechanisms.A response at lower flux densities is seen in certain studies, although not consistently.

View Article: PubMed Central - PubMed

Affiliation: Environmental Resources and Technologies, Department Health and Environment, AIT Austrian Institute of Technology , Tulln , Austria.

ABSTRACT
A large body of literature deals with biological effects of extremely low-frequency magnetic fields (ELF MFs) studied in vitro. Despite the multitude of studies, no coherent picture has evolved regarding the plausibility of effects at low-flux densities or regarding the interaction mechanisms. Here, we propose that ELF MF exposure in vitro causes changes in oxidative status as an early response. We tested this hypothesis by scrutinizing the literature and applying a grouping approach for analyzing relevant biological properties and exposure conditions. A total of 41 scientific original publications were analyzed for this purpose. The conclusion from the work is that ELF MF (modulated or unmodulated) consistently can influence the oxidative status, at or above 1 mT, in a broad range of cell types and independent of exposure duration. A response at lower flux densities is seen in certain studies, although not consistently. Further studies with stringent protocols for sham exposure, blinding, and statistical analysis as well as appropriate positive controls are needed to establish if true dose-relationships for effects on oxidative status exist.

No MeSH data available.


Related in: MedlinePlus

The use of positive controls in investigating oxidative response as a positive or negative finding after exposure to ELF MF.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4151017&req=5

Figure 5: The use of positive controls in investigating oxidative response as a positive or negative finding after exposure to ELF MF.

Mentions: To investigate the quality of the studies, where proper sham control conditions, statistical analysis, and other criteria such as blinded protocols were not taken into account (since this would have reduced the number of relevant studies very dramatically), we analyzed how often positive controls were applied as a quality control measure of the study. Of the positive findings, 21 investigations used positive controls. Many of these were investigating co-exposure effects (62%) (Figure 5). Among the negative findings, five papers reported the use of positive controls, all in studies of co-exposure effects.


Grouping of Experimental Conditions as an Approach to Evaluate Effects of Extremely Low-Frequency Magnetic Fields on Oxidative Response in in vitro Studies.

Mattsson MO, Simkó M - Front Public Health (2014)

The use of positive controls in investigating oxidative response as a positive or negative finding after exposure to ELF MF.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4151017&req=5

Figure 5: The use of positive controls in investigating oxidative response as a positive or negative finding after exposure to ELF MF.
Mentions: To investigate the quality of the studies, where proper sham control conditions, statistical analysis, and other criteria such as blinded protocols were not taken into account (since this would have reduced the number of relevant studies very dramatically), we analyzed how often positive controls were applied as a quality control measure of the study. Of the positive findings, 21 investigations used positive controls. Many of these were investigating co-exposure effects (62%) (Figure 5). Among the negative findings, five papers reported the use of positive controls, all in studies of co-exposure effects.

Bottom Line: A large body of literature deals with biological effects of extremely low-frequency magnetic fields (ELF MFs) studied in vitro.Despite the multitude of studies, no coherent picture has evolved regarding the plausibility of effects at low-flux densities or regarding the interaction mechanisms.A response at lower flux densities is seen in certain studies, although not consistently.

View Article: PubMed Central - PubMed

Affiliation: Environmental Resources and Technologies, Department Health and Environment, AIT Austrian Institute of Technology , Tulln , Austria.

ABSTRACT
A large body of literature deals with biological effects of extremely low-frequency magnetic fields (ELF MFs) studied in vitro. Despite the multitude of studies, no coherent picture has evolved regarding the plausibility of effects at low-flux densities or regarding the interaction mechanisms. Here, we propose that ELF MF exposure in vitro causes changes in oxidative status as an early response. We tested this hypothesis by scrutinizing the literature and applying a grouping approach for analyzing relevant biological properties and exposure conditions. A total of 41 scientific original publications were analyzed for this purpose. The conclusion from the work is that ELF MF (modulated or unmodulated) consistently can influence the oxidative status, at or above 1 mT, in a broad range of cell types and independent of exposure duration. A response at lower flux densities is seen in certain studies, although not consistently. Further studies with stringent protocols for sham exposure, blinding, and statistical analysis as well as appropriate positive controls are needed to establish if true dose-relationships for effects on oxidative status exist.

No MeSH data available.


Related in: MedlinePlus