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Grouping of Experimental Conditions as an Approach to Evaluate Effects of Extremely Low-Frequency Magnetic Fields on Oxidative Response in in vitro Studies.

Mattsson MO, Simkó M - Front Public Health (2014)

Bottom Line: A large body of literature deals with biological effects of extremely low-frequency magnetic fields (ELF MFs) studied in vitro.Despite the multitude of studies, no coherent picture has evolved regarding the plausibility of effects at low-flux densities or regarding the interaction mechanisms.A response at lower flux densities is seen in certain studies, although not consistently.

View Article: PubMed Central - PubMed

Affiliation: Environmental Resources and Technologies, Department Health and Environment, AIT Austrian Institute of Technology , Tulln , Austria.

ABSTRACT
A large body of literature deals with biological effects of extremely low-frequency magnetic fields (ELF MFs) studied in vitro. Despite the multitude of studies, no coherent picture has evolved regarding the plausibility of effects at low-flux densities or regarding the interaction mechanisms. Here, we propose that ELF MF exposure in vitro causes changes in oxidative status as an early response. We tested this hypothesis by scrutinizing the literature and applying a grouping approach for analyzing relevant biological properties and exposure conditions. A total of 41 scientific original publications were analyzed for this purpose. The conclusion from the work is that ELF MF (modulated or unmodulated) consistently can influence the oxidative status, at or above 1 mT, in a broad range of cell types and independent of exposure duration. A response at lower flux densities is seen in certain studies, although not consistently. Further studies with stringent protocols for sham exposure, blinding, and statistical analysis as well as appropriate positive controls are needed to establish if true dose-relationships for effects on oxidative status exist.

No MeSH data available.


Related in: MedlinePlus

Oxidative response as a positive or negative finding after exposure to different flux densities of ELF MF in different cell types.
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Figure 3: Oxidative response as a positive or negative finding after exposure to different flux densities of ELF MF in different cell types.

Mentions: To analyze the flux density dependency of the performed studies, we grouped the employed field strength as follows: ≤0.1, 0.1–0.99, and ≥1 mT. Some investigators used several different flux densities. Out of 68 investigations, 51 detected positive findings: 30 used ≥1 mT, 9 used 0.1–0.99 mT, and at 12 times ≤0.1 mT was employed. No effects were detected in a total of 17 investigations (2 in ≥1 mT, 8 in 0.1–0.99 mT, and 7 in the group of ≤0.1 mT). It seems that below 0.1 mT and around 1 mT oxidative response appears in the majority of the used immune-relevant primary cells (23) (Figure 3). Based on this data, it is plausible to suggest that ≥1 mT induces oxidative responses (30) with a ratio of 0.94. At the other flux density levels, this distinct picture does not appear. The ratio for positive findings is in the group of <0.1 mT 0.63 and in the group of 0.1–0.99 mT 0.53.


Grouping of Experimental Conditions as an Approach to Evaluate Effects of Extremely Low-Frequency Magnetic Fields on Oxidative Response in in vitro Studies.

Mattsson MO, Simkó M - Front Public Health (2014)

Oxidative response as a positive or negative finding after exposure to different flux densities of ELF MF in different cell types.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4151017&req=5

Figure 3: Oxidative response as a positive or negative finding after exposure to different flux densities of ELF MF in different cell types.
Mentions: To analyze the flux density dependency of the performed studies, we grouped the employed field strength as follows: ≤0.1, 0.1–0.99, and ≥1 mT. Some investigators used several different flux densities. Out of 68 investigations, 51 detected positive findings: 30 used ≥1 mT, 9 used 0.1–0.99 mT, and at 12 times ≤0.1 mT was employed. No effects were detected in a total of 17 investigations (2 in ≥1 mT, 8 in 0.1–0.99 mT, and 7 in the group of ≤0.1 mT). It seems that below 0.1 mT and around 1 mT oxidative response appears in the majority of the used immune-relevant primary cells (23) (Figure 3). Based on this data, it is plausible to suggest that ≥1 mT induces oxidative responses (30) with a ratio of 0.94. At the other flux density levels, this distinct picture does not appear. The ratio for positive findings is in the group of <0.1 mT 0.63 and in the group of 0.1–0.99 mT 0.53.

Bottom Line: A large body of literature deals with biological effects of extremely low-frequency magnetic fields (ELF MFs) studied in vitro.Despite the multitude of studies, no coherent picture has evolved regarding the plausibility of effects at low-flux densities or regarding the interaction mechanisms.A response at lower flux densities is seen in certain studies, although not consistently.

View Article: PubMed Central - PubMed

Affiliation: Environmental Resources and Technologies, Department Health and Environment, AIT Austrian Institute of Technology , Tulln , Austria.

ABSTRACT
A large body of literature deals with biological effects of extremely low-frequency magnetic fields (ELF MFs) studied in vitro. Despite the multitude of studies, no coherent picture has evolved regarding the plausibility of effects at low-flux densities or regarding the interaction mechanisms. Here, we propose that ELF MF exposure in vitro causes changes in oxidative status as an early response. We tested this hypothesis by scrutinizing the literature and applying a grouping approach for analyzing relevant biological properties and exposure conditions. A total of 41 scientific original publications were analyzed for this purpose. The conclusion from the work is that ELF MF (modulated or unmodulated) consistently can influence the oxidative status, at or above 1 mT, in a broad range of cell types and independent of exposure duration. A response at lower flux densities is seen in certain studies, although not consistently. Further studies with stringent protocols for sham exposure, blinding, and statistical analysis as well as appropriate positive controls are needed to establish if true dose-relationships for effects on oxidative status exist.

No MeSH data available.


Related in: MedlinePlus