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HMOX1 gene promoter polymorphism is not associated with coronary artery disease in Koreans.

Han SW, Song W, Kim HS, Shin KS, Kang H, Cho HC, Ki CS, Park MJ - Ann Lab Med (2014)

Bottom Line: Multivariate logistic regression analysis revealed that the genotypes of (GT)n repeats were not related to CAD status.The restenosis group in the coronary angiography follow-up did not show any significant difference in HMOX1 genotype frequency.The HMOX1 genotypes were not found to be associated with CAD, but the short allele carrier group contained more individuals with hsCRP values reflecting low risk of cardiovascular disease in the Korean population.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Hallym University College of Medicine, Seoul, Korea.

ABSTRACT

Background: The heme oxygenase-1 gene (HMOX1) promoter polymorphisms modulate its transcription in response to oxidative stress. This study screened for HMOX1 polymorphisms and investigated the association between HMOX1 polymorphisms and coronary artery disease (CAD) in the Korean population.

Methods: The study population consisted of patients with CAD with obstructive lesions (n=110), CAD with minimal or no lesions (n=40), and controls (n=107). Thirty-nine patients with CAD with obstructive lesions underwent follow-up coronary angiography after six months for the presence of restenosis. The 5'-flanking region containing (GT)n repeats of the HMOX1 gene was analyzed by PCR.

Results: The numbers of (GT)n repeats in the HMOX1 promoter showed a bimodal distribution. The alleles were divided into two subclasses, S25 and L25, depending on whether there were less than or equal to and more than 25 (GT)n repeats, respectively. The allele and genotype frequencies among groups were statistically not different. More subjects in the S25-carrier group had the low risk levels of high sensitivity C-reactive protein (hsCRP) for the CAD than those in the non-S25 carrier group (P=0.034). Multivariate logistic regression analysis revealed that the genotypes of (GT)n repeats were not related to CAD status. The restenosis group in the coronary angiography follow-up did not show any significant difference in HMOX1 genotype frequency.

Conclusions: The HMOX1 genotypes were not found to be associated with CAD, but the short allele carrier group contained more individuals with hsCRP values reflecting low risk of cardiovascular disease in the Korean population.

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Related in: MedlinePlus

The frequency distributions of the numbers of (GT)n repeats of the HMOX1 promoter. (A) Total study populations (N=257), (B) CAD with obstructive lesions group (N=110), (C) MD (N=40), and (D) controls (N=107).Abbreviations: CAD, coronary artery disease, CAOD, coronary artery disease with obstructive lesions; MD, coronary artery disease with minimal or no lesions.
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Figure 1: The frequency distributions of the numbers of (GT)n repeats of the HMOX1 promoter. (A) Total study populations (N=257), (B) CAD with obstructive lesions group (N=110), (C) MD (N=40), and (D) controls (N=107).Abbreviations: CAD, coronary artery disease, CAOD, coronary artery disease with obstructive lesions; MD, coronary artery disease with minimal or no lesions.

Mentions: Analysis of the HMOX1 gene promoter polymorphism revealed that the number of (GT)n repeats ranged from 16 to 41, showing a bimodal distribution, in which the highest frequencies were shown at 23 and 30 repeats (Fig. 1).


HMOX1 gene promoter polymorphism is not associated with coronary artery disease in Koreans.

Han SW, Song W, Kim HS, Shin KS, Kang H, Cho HC, Ki CS, Park MJ - Ann Lab Med (2014)

The frequency distributions of the numbers of (GT)n repeats of the HMOX1 promoter. (A) Total study populations (N=257), (B) CAD with obstructive lesions group (N=110), (C) MD (N=40), and (D) controls (N=107).Abbreviations: CAD, coronary artery disease, CAOD, coronary artery disease with obstructive lesions; MD, coronary artery disease with minimal or no lesions.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4151001&req=5

Figure 1: The frequency distributions of the numbers of (GT)n repeats of the HMOX1 promoter. (A) Total study populations (N=257), (B) CAD with obstructive lesions group (N=110), (C) MD (N=40), and (D) controls (N=107).Abbreviations: CAD, coronary artery disease, CAOD, coronary artery disease with obstructive lesions; MD, coronary artery disease with minimal or no lesions.
Mentions: Analysis of the HMOX1 gene promoter polymorphism revealed that the number of (GT)n repeats ranged from 16 to 41, showing a bimodal distribution, in which the highest frequencies were shown at 23 and 30 repeats (Fig. 1).

Bottom Line: Multivariate logistic regression analysis revealed that the genotypes of (GT)n repeats were not related to CAD status.The restenosis group in the coronary angiography follow-up did not show any significant difference in HMOX1 genotype frequency.The HMOX1 genotypes were not found to be associated with CAD, but the short allele carrier group contained more individuals with hsCRP values reflecting low risk of cardiovascular disease in the Korean population.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Hallym University College of Medicine, Seoul, Korea.

ABSTRACT

Background: The heme oxygenase-1 gene (HMOX1) promoter polymorphisms modulate its transcription in response to oxidative stress. This study screened for HMOX1 polymorphisms and investigated the association between HMOX1 polymorphisms and coronary artery disease (CAD) in the Korean population.

Methods: The study population consisted of patients with CAD with obstructive lesions (n=110), CAD with minimal or no lesions (n=40), and controls (n=107). Thirty-nine patients with CAD with obstructive lesions underwent follow-up coronary angiography after six months for the presence of restenosis. The 5'-flanking region containing (GT)n repeats of the HMOX1 gene was analyzed by PCR.

Results: The numbers of (GT)n repeats in the HMOX1 promoter showed a bimodal distribution. The alleles were divided into two subclasses, S25 and L25, depending on whether there were less than or equal to and more than 25 (GT)n repeats, respectively. The allele and genotype frequencies among groups were statistically not different. More subjects in the S25-carrier group had the low risk levels of high sensitivity C-reactive protein (hsCRP) for the CAD than those in the non-S25 carrier group (P=0.034). Multivariate logistic regression analysis revealed that the genotypes of (GT)n repeats were not related to CAD status. The restenosis group in the coronary angiography follow-up did not show any significant difference in HMOX1 genotype frequency.

Conclusions: The HMOX1 genotypes were not found to be associated with CAD, but the short allele carrier group contained more individuals with hsCRP values reflecting low risk of cardiovascular disease in the Korean population.

Show MeSH
Related in: MedlinePlus