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"Coffee plus honey" versus "topical steroid" in the treatment of chemotherapy-induced oral mucositis: a randomised controlled trial.

Raeessi MA, Raeessi N, Panahi Y, Gharaie H, Davoudi SM, Saadat A, Karimi Zarchi AA, Raeessi F, Ahmadi SM, Jalalian H - BMC Complement Altern Med (2014)

Bottom Line: This study showed that all three treatment regimens reduce the severity of lesions.The best reduction in severity was achieved in HC group.H group and S group took the second and third places.

View Article: PubMed Central - PubMed

Affiliation: Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. raeessi_neda@yahoo.com.

ABSTRACT

Background: Oral mucositis is one of the common complications of cancer chemotherapy and about 40% of the patients who take chemotherapy protocols, experience this irritating problem. The purpose of this study was to draw comparison between the therapeutic effects of our treatment modalities (topical steroid, honey, honey plus coffee) in patients suffering from oral mucositis.

Methods: This was a double blinded randomised clinical trial of a total of 75 eligible adult participants which they randomly fell into three treatment groups. For all the participants a syrup-like solution was prepared. Each 600 grams of the product consisted of "20 eight-mg Betamethasone solution ampoules" in the Steroid (S) group, "300 grams of honey plus 20 grams of instant coffee" in the Honey plus Coffee (HC) group, and "300 grams of honey" for the Honey (H) group. The participants were told to sip 10 ml of the prescribed product, and then swallow it every three hours for one week. Severity of lesions was clinically evaluated before the treatment and also one week after the initiation of the intervention. This study adhered to the principles of the Declaration of Helsinki and guidelines of Good Clinical Practice.

Results: This study showed that all three treatment regimens reduce the severity of lesions. The best reduction in severity was achieved in HC group. H group and S group took the second and third places. In other words, honey plus coffee regimen was the most effective modality for the treatment of oral mucositis.

Conclusion: Oral mucositis can be successfully treated by a combination of honey and coffee as an alternative medicine in a short time. Further investigations are warranted in this field.

Trial registration: Iranian Registry of Clinical Trials IRCT: 201104074737N3, (9 May 2011).

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Related in: MedlinePlus

The flow diagram of the study.
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Fig1: The flow diagram of the study.

Mentions: For each group, the numbers of participants who were randomly enrolled, received intended treatment and were analysed along with the losses and exclusions are depicted in the flow diagram (Figure 1). In this clinical trial the mean (STD) of age and weight were 55.2 (13.2) years, and 77.4 (10.4) kgs respectively. Also the mean (STD) of the severity of illness was 2.57 (0.49) pre-treatment and 0.90 (0.76) post-treatment (Table 2). One-way analysis of variances and Wilcoxon signed rank test, showed that the differences between variables including age and severity of illness before treatment in all three groups were the same and were not statistically significant (p > 0.05, Table 2). The Chi-square test showed that the distribution of variables including sex and education levels were the same in the three groups (p > 0.05).Figure 1


"Coffee plus honey" versus "topical steroid" in the treatment of chemotherapy-induced oral mucositis: a randomised controlled trial.

Raeessi MA, Raeessi N, Panahi Y, Gharaie H, Davoudi SM, Saadat A, Karimi Zarchi AA, Raeessi F, Ahmadi SM, Jalalian H - BMC Complement Altern Med (2014)

The flow diagram of the study.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4150938&req=5

Fig1: The flow diagram of the study.
Mentions: For each group, the numbers of participants who were randomly enrolled, received intended treatment and were analysed along with the losses and exclusions are depicted in the flow diagram (Figure 1). In this clinical trial the mean (STD) of age and weight were 55.2 (13.2) years, and 77.4 (10.4) kgs respectively. Also the mean (STD) of the severity of illness was 2.57 (0.49) pre-treatment and 0.90 (0.76) post-treatment (Table 2). One-way analysis of variances and Wilcoxon signed rank test, showed that the differences between variables including age and severity of illness before treatment in all three groups were the same and were not statistically significant (p > 0.05, Table 2). The Chi-square test showed that the distribution of variables including sex and education levels were the same in the three groups (p > 0.05).Figure 1

Bottom Line: This study showed that all three treatment regimens reduce the severity of lesions.The best reduction in severity was achieved in HC group.H group and S group took the second and third places.

View Article: PubMed Central - PubMed

Affiliation: Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. raeessi_neda@yahoo.com.

ABSTRACT

Background: Oral mucositis is one of the common complications of cancer chemotherapy and about 40% of the patients who take chemotherapy protocols, experience this irritating problem. The purpose of this study was to draw comparison between the therapeutic effects of our treatment modalities (topical steroid, honey, honey plus coffee) in patients suffering from oral mucositis.

Methods: This was a double blinded randomised clinical trial of a total of 75 eligible adult participants which they randomly fell into three treatment groups. For all the participants a syrup-like solution was prepared. Each 600 grams of the product consisted of "20 eight-mg Betamethasone solution ampoules" in the Steroid (S) group, "300 grams of honey plus 20 grams of instant coffee" in the Honey plus Coffee (HC) group, and "300 grams of honey" for the Honey (H) group. The participants were told to sip 10 ml of the prescribed product, and then swallow it every three hours for one week. Severity of lesions was clinically evaluated before the treatment and also one week after the initiation of the intervention. This study adhered to the principles of the Declaration of Helsinki and guidelines of Good Clinical Practice.

Results: This study showed that all three treatment regimens reduce the severity of lesions. The best reduction in severity was achieved in HC group. H group and S group took the second and third places. In other words, honey plus coffee regimen was the most effective modality for the treatment of oral mucositis.

Conclusion: Oral mucositis can be successfully treated by a combination of honey and coffee as an alternative medicine in a short time. Further investigations are warranted in this field.

Trial registration: Iranian Registry of Clinical Trials IRCT: 201104074737N3, (9 May 2011).

Show MeSH
Related in: MedlinePlus