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The application of functional imaging techniques to personalise chemoradiotherapy in upper gastrointestinal malignancies.

Wilson JM, Partridge M, Hawkins M - Clin Oncol (R Coll Radiol) (2014)

Bottom Line: The sensitivity and specificity of FDG-PET to predict treatment response and survival are not currently high enough to inform treatment decisions.FDG-PET improves target volume definition in oesophageal cancer by improving the accuracy of tumour length definition and by improving the nodal staging of patients.The current limitations of published studies prevent integrating imaging-derived parameters into decision making on an individual patient basis.

View Article: PubMed Central - PubMed

Affiliation: CRUK/MRC Oxford Institute for Radiation Oncology, Gray Laboratories, University of Oxford, Old Road Campus Research Building, Oxford, UK. Electronic address: james.wilson@oncology.ox.ac.uk.

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Magnified view of a trans-axial section through a locally advanced pancreatic adenocarcinoma. The gross tumour volume (GTV; red) was agreed by two radiation oncologists using only the planning contrast enhanced CT (CECT). Following registration with 18F-fluorodeoxyglucose positron emission tomography (FDG-PET), it can be seen that FDG-avid tissue extends beyond the GTV. A semi-automated process can produce volumes outlined by 40% of the maximum standardised uptake value (SUVmax; blue) or 50% of the SUVmax, which may facilitate accurate GTV definition.
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fig1: Magnified view of a trans-axial section through a locally advanced pancreatic adenocarcinoma. The gross tumour volume (GTV; red) was agreed by two radiation oncologists using only the planning contrast enhanced CT (CECT). Following registration with 18F-fluorodeoxyglucose positron emission tomography (FDG-PET), it can be seen that FDG-avid tissue extends beyond the GTV. A semi-automated process can produce volumes outlined by 40% of the maximum standardised uptake value (SUVmax; blue) or 50% of the SUVmax, which may facilitate accurate GTV definition.


The application of functional imaging techniques to personalise chemoradiotherapy in upper gastrointestinal malignancies.

Wilson JM, Partridge M, Hawkins M - Clin Oncol (R Coll Radiol) (2014)

Magnified view of a trans-axial section through a locally advanced pancreatic adenocarcinoma. The gross tumour volume (GTV; red) was agreed by two radiation oncologists using only the planning contrast enhanced CT (CECT). Following registration with 18F-fluorodeoxyglucose positron emission tomography (FDG-PET), it can be seen that FDG-avid tissue extends beyond the GTV. A semi-automated process can produce volumes outlined by 40% of the maximum standardised uptake value (SUVmax; blue) or 50% of the SUVmax, which may facilitate accurate GTV definition.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150923&req=5

fig1: Magnified view of a trans-axial section through a locally advanced pancreatic adenocarcinoma. The gross tumour volume (GTV; red) was agreed by two radiation oncologists using only the planning contrast enhanced CT (CECT). Following registration with 18F-fluorodeoxyglucose positron emission tomography (FDG-PET), it can be seen that FDG-avid tissue extends beyond the GTV. A semi-automated process can produce volumes outlined by 40% of the maximum standardised uptake value (SUVmax; blue) or 50% of the SUVmax, which may facilitate accurate GTV definition.
Bottom Line: The sensitivity and specificity of FDG-PET to predict treatment response and survival are not currently high enough to inform treatment decisions.FDG-PET improves target volume definition in oesophageal cancer by improving the accuracy of tumour length definition and by improving the nodal staging of patients.The current limitations of published studies prevent integrating imaging-derived parameters into decision making on an individual patient basis.

View Article: PubMed Central - PubMed

Affiliation: CRUK/MRC Oxford Institute for Radiation Oncology, Gray Laboratories, University of Oxford, Old Road Campus Research Building, Oxford, UK. Electronic address: james.wilson@oncology.ox.ac.uk.

Show MeSH
Related in: MedlinePlus