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Low computed tomography coronary artery calcium scores in familial longevity: the Leiden Longevity Study.

Kroft LJ, van der Bijl N, van der Grond J, Altmann-Schneider I, Slagboom PE, Westendorp RG, de Roos A, de Craen AJ - Age (Dordr) (2014)

Bottom Line: Differences remained significant after correction for age (men, p = 0.043 and women, p = 0.003) and further correction for major risk factors in women, indicating genetic influence for lower calcium scores.Men and women with a familial propensity to become long-lived have lower coronary artery calcium scores than controls.Low scores may indicate a younger biologic arterial age associated with a low risk for incident cardiovascular disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, C2S, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands, L.J.M.Kroft@lumc.nl.

ABSTRACT
Offspring of long-lived parents have a low prevalence of cardiovascular disease in middle age. The purposes of this study were to investigate calcium scores in offspring as compared to controls and to determine the influence of cardiovascular risk factors. CT coronary artery calcium score was measured in offspring of long-lived families (n = 244, 125 males) and their partners (n = 223, 96 males) who served as controls. Calcium scores were analyzed separately for sexes. Subjects were grouped by very low calcium score ≤10 and scores above 10. Nonparametric Mann-Whitney test, chi-squared tests, and logistic regression analyses were performed to determine the association between calcium scores, familial longevity, and cardiovascular risk factors. More offspring of long-lived parents had lower calcium scores than controls. In men, 34 % of offspring had score ≤10 versus 21 % of controls (odds ratio (OR) and 95 % confidence interval (CI) 2.0, 1.08-3.7, p = 0.028). In women, 70 % of offspring had score ≤10 versus 54 % of controls (OR 1.9, 95 % CI 1.13-3.4, p = 0.019). Differences remained significant after correction for age (men, p = 0.043 and women, p = 0.003) and further correction for major risk factors in women, indicating genetic influence for lower calcium scores. In men, the association was found to be influenced by cardiovascular risk factors. Men and women with a familial propensity to become long-lived have lower coronary artery calcium scores than controls. Low scores may indicate a younger biologic arterial age associated with a low risk for incident cardiovascular disease.

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The percentage of subjects for men (a) and women (b) with calcium scores >10 for quartile age categories within each group. Age groups were divided by comparable numbers of 55–58 subjects in each quartile group. Quartile mean ages for groups in men (a) are as follows: group 1 aged 48.7–62.8 years, mean age 58.8 years; group 2 aged 62.9–67.1 years, mean age 64.9 years; group 3 aged 67.2–71.1 years, mean age 69.0 years; and group 4 aged 71.2–84.4 years, mean age 75.2 years. Quartile mean ages for groups in women (b) are as follows: group 1 aged 45.5–61.0 years, mean age 56.3 years; group 2 aged 61.1–64.9 years, mean age 62.8 years; group 3 aged 65.0–68.8 years, mean age 66.9 years; and group 4 aged 68.9–81.6 years, mean age 72.4 years. In all age groups, for men and women, the percentage individuals with calcium score >10 was lower for offspring of long-lived parents than for controls. Also, the percentage calcium scores >10 increase with age. The figures suggest that offspring are biologically younger for their age as compared to age-matched controls
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Fig2: The percentage of subjects for men (a) and women (b) with calcium scores >10 for quartile age categories within each group. Age groups were divided by comparable numbers of 55–58 subjects in each quartile group. Quartile mean ages for groups in men (a) are as follows: group 1 aged 48.7–62.8 years, mean age 58.8 years; group 2 aged 62.9–67.1 years, mean age 64.9 years; group 3 aged 67.2–71.1 years, mean age 69.0 years; and group 4 aged 71.2–84.4 years, mean age 75.2 years. Quartile mean ages for groups in women (b) are as follows: group 1 aged 45.5–61.0 years, mean age 56.3 years; group 2 aged 61.1–64.9 years, mean age 62.8 years; group 3 aged 65.0–68.8 years, mean age 66.9 years; and group 4 aged 68.9–81.6 years, mean age 72.4 years. In all age groups, for men and women, the percentage individuals with calcium score >10 was lower for offspring of long-lived parents than for controls. Also, the percentage calcium scores >10 increase with age. The figures suggest that offspring are biologically younger for their age as compared to age-matched controls

Mentions: Figure 1 shows an example of CT calcium scoring in offspring and control. In men, median (IQR) calcium score in offspring was 58 (1–295) versus 79 (14–440) in controls (p = 0.08). In women, median (IQR) calcium score in offspring was 0 (0–25) versus 3 (0–75) in controls (p = 0.09). Whereas the median calcium score did not differ between the groups, the distribution was significantly different. Table 2 shows the distribution of the calcium scores ≤10 versus >10 for men and women. Significantly, more male offspring from long-lived parents had a calcium score ≤10 than male controls; 34 % of offspring had a calcium score ≤10 versus 21 % of controls (odds ratio (OR) = 2.0, 95 % CI 1.08–3.7, p = 0.028). In females, 70 % of offspring had a calcium score ≤10 versus 54 % of controls (OR = 1.9, 95 % CI 1.1–3.4, p = 0.019). Figure 2 shows for men and women the percentage of individuals with calcium scores >10 for quartile age categories with comparable numbers of participants within the groups. In all age groups, for both men and women, the percentage of individuals with calcium score >10 was lower for the offspring of long-lived parents than for controls. In addition, the percentage calcium score >10 increases with age. Figure 2 suggests that offspring are biologically younger for their age as compared to age-matched controls.Table 2


Low computed tomography coronary artery calcium scores in familial longevity: the Leiden Longevity Study.

Kroft LJ, van der Bijl N, van der Grond J, Altmann-Schneider I, Slagboom PE, Westendorp RG, de Roos A, de Craen AJ - Age (Dordr) (2014)

The percentage of subjects for men (a) and women (b) with calcium scores >10 for quartile age categories within each group. Age groups were divided by comparable numbers of 55–58 subjects in each quartile group. Quartile mean ages for groups in men (a) are as follows: group 1 aged 48.7–62.8 years, mean age 58.8 years; group 2 aged 62.9–67.1 years, mean age 64.9 years; group 3 aged 67.2–71.1 years, mean age 69.0 years; and group 4 aged 71.2–84.4 years, mean age 75.2 years. Quartile mean ages for groups in women (b) are as follows: group 1 aged 45.5–61.0 years, mean age 56.3 years; group 2 aged 61.1–64.9 years, mean age 62.8 years; group 3 aged 65.0–68.8 years, mean age 66.9 years; and group 4 aged 68.9–81.6 years, mean age 72.4 years. In all age groups, for men and women, the percentage individuals with calcium score >10 was lower for offspring of long-lived parents than for controls. Also, the percentage calcium scores >10 increase with age. The figures suggest that offspring are biologically younger for their age as compared to age-matched controls
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

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Fig2: The percentage of subjects for men (a) and women (b) with calcium scores >10 for quartile age categories within each group. Age groups were divided by comparable numbers of 55–58 subjects in each quartile group. Quartile mean ages for groups in men (a) are as follows: group 1 aged 48.7–62.8 years, mean age 58.8 years; group 2 aged 62.9–67.1 years, mean age 64.9 years; group 3 aged 67.2–71.1 years, mean age 69.0 years; and group 4 aged 71.2–84.4 years, mean age 75.2 years. Quartile mean ages for groups in women (b) are as follows: group 1 aged 45.5–61.0 years, mean age 56.3 years; group 2 aged 61.1–64.9 years, mean age 62.8 years; group 3 aged 65.0–68.8 years, mean age 66.9 years; and group 4 aged 68.9–81.6 years, mean age 72.4 years. In all age groups, for men and women, the percentage individuals with calcium score >10 was lower for offspring of long-lived parents than for controls. Also, the percentage calcium scores >10 increase with age. The figures suggest that offspring are biologically younger for their age as compared to age-matched controls
Mentions: Figure 1 shows an example of CT calcium scoring in offspring and control. In men, median (IQR) calcium score in offspring was 58 (1–295) versus 79 (14–440) in controls (p = 0.08). In women, median (IQR) calcium score in offspring was 0 (0–25) versus 3 (0–75) in controls (p = 0.09). Whereas the median calcium score did not differ between the groups, the distribution was significantly different. Table 2 shows the distribution of the calcium scores ≤10 versus >10 for men and women. Significantly, more male offspring from long-lived parents had a calcium score ≤10 than male controls; 34 % of offspring had a calcium score ≤10 versus 21 % of controls (odds ratio (OR) = 2.0, 95 % CI 1.08–3.7, p = 0.028). In females, 70 % of offspring had a calcium score ≤10 versus 54 % of controls (OR = 1.9, 95 % CI 1.1–3.4, p = 0.019). Figure 2 shows for men and women the percentage of individuals with calcium scores >10 for quartile age categories with comparable numbers of participants within the groups. In all age groups, for both men and women, the percentage of individuals with calcium score >10 was lower for the offspring of long-lived parents than for controls. In addition, the percentage calcium score >10 increases with age. Figure 2 suggests that offspring are biologically younger for their age as compared to age-matched controls.Table 2

Bottom Line: Differences remained significant after correction for age (men, p = 0.043 and women, p = 0.003) and further correction for major risk factors in women, indicating genetic influence for lower calcium scores.Men and women with a familial propensity to become long-lived have lower coronary artery calcium scores than controls.Low scores may indicate a younger biologic arterial age associated with a low risk for incident cardiovascular disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, C2S, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands, L.J.M.Kroft@lumc.nl.

ABSTRACT
Offspring of long-lived parents have a low prevalence of cardiovascular disease in middle age. The purposes of this study were to investigate calcium scores in offspring as compared to controls and to determine the influence of cardiovascular risk factors. CT coronary artery calcium score was measured in offspring of long-lived families (n = 244, 125 males) and their partners (n = 223, 96 males) who served as controls. Calcium scores were analyzed separately for sexes. Subjects were grouped by very low calcium score ≤10 and scores above 10. Nonparametric Mann-Whitney test, chi-squared tests, and logistic regression analyses were performed to determine the association between calcium scores, familial longevity, and cardiovascular risk factors. More offspring of long-lived parents had lower calcium scores than controls. In men, 34 % of offspring had score ≤10 versus 21 % of controls (odds ratio (OR) and 95 % confidence interval (CI) 2.0, 1.08-3.7, p = 0.028). In women, 70 % of offspring had score ≤10 versus 54 % of controls (OR 1.9, 95 % CI 1.13-3.4, p = 0.019). Differences remained significant after correction for age (men, p = 0.043 and women, p = 0.003) and further correction for major risk factors in women, indicating genetic influence for lower calcium scores. In men, the association was found to be influenced by cardiovascular risk factors. Men and women with a familial propensity to become long-lived have lower coronary artery calcium scores than controls. Low scores may indicate a younger biologic arterial age associated with a low risk for incident cardiovascular disease.

Show MeSH
Related in: MedlinePlus