Drosophila COP9 signalosome subunit 7 interacts with multiple genomic loci to regulate development.
Bottom Line: While the function of this complex in ubiquitin-mediated protein degradation is well established, results over the past few years have hinted that the COP9 signalosome may function more broadly in the regulation of gene expression.These results indicate that CSN7, and by extension the entire COP9 signalosome, functions directly in transcriptional control.While the COP9 signalosome protein complex has long been known to regulate protein degradation, here we expand the role of this complex by showing that subunit 7 binds DNA in vitro and functions directly in vivo in transcriptional control of developmentally important pathways that are relevant for human health.
Affiliation: Department of Molecular Biology and Ecology of Plants.Show MeSH
Mentions: For Figure 2A, genes were divided into groups according to their fold change in the csn4 mutant at time 60 h AED (4). For each group the mean signal based on the CSN7 DamID experiment over the genomic region defined above was computed.
Affiliation: Department of Molecular Biology and Ecology of Plants.