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Changing patterns of propagation in a super-refractory status of the temporal lobe. Over 900 seizures recorded over nearly one year.

Napolitano CE, Orriols MA - Epilepsy Behav Case Rep (2013)

Bottom Line: Our goals were to study the propagation models in a situation of persistent temporal epileptic seizures with varying degrees of bitemporal excitability and to analyze which propagation models were found at times of high temporal excitability and which occurred with lower levels of excitability.From the beginning, the interictal recording showed independent discharges over both temporal lobes.The analysis of the propagation models may provide information about the excitability of the mesial temporal-limbic network.

View Article: PubMed Central - PubMed

Affiliation: Neurology Service, Electroencephalography Department, Military Hospital, Santiago, Chile.

ABSTRACT

Objective: Our goals were to study the propagation models in a situation of persistent temporal epileptic seizures with varying degrees of bitemporal excitability and to analyze which propagation models were found at times of high temporal excitability and which occurred with lower levels of excitability.

Methods: A patient with super-refractory status arising from the temporal lobes was studied daily using video-electroencephalography (VEEG), with a large number of electroclinical seizures recorded. The analysis focused on the method and type of seizure propagation and classified them either according to the propagation models described in the literature or as undetermined.

Results: Video-EEG monitoring was carried out daily for 310 days. A total of 990 electroclinical seizures were recorded; 135 seizures were recorded during the first week, and 523 were recorded in the first month. From the beginning, the interictal recording showed independent discharges over both temporal lobes. The seizures showed independent onset in both temporal lobes. During periods of the highest number of seizures, certain models of propagation begin to predominate through switch of lateralization, temporal asynchrony, early remote propagation, total contralateral propagation, seizures with nonlocalized onset, or models that are difficult to classify. Conversely, when the condition was brought relatively under control, we observed fewer propagation models with predominantly simple patterns: only hemispheric propagation or graduated sequential propagation with a few nonlateralized onset seizures.

Conclusions: Upon analyzing the seizures, we found that the propagation models vary as the status evolved, with the change reflecting the degree of excitability in the mesial temporal-limbic network at a given time. In clinical practice, these changes in propagation models are more likely to be observed in temporal status that extends over time and with an onset of the seizures in both temporal lobes.

Significance: The analysis of the propagation models may provide information about the excitability of the mesial temporal-limbic network.

No MeSH data available.


Related in: MedlinePlus

Recording from Day 8: 70 seizures, independent onset in the right and left temporal lobes. Six propagation models (see text). EEG: left temporal onset with early remote propagation plus temporal asynchrony and switch of lateralization. Note the large area involved at the onset of the seizure and the difference in speed in the discharge's propagation to the contralateral hemisphere as compared to Fig. 2. (A–C) Without interruption, (D) 72 s after onset.
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f0015: Recording from Day 8: 70 seizures, independent onset in the right and left temporal lobes. Six propagation models (see text). EEG: left temporal onset with early remote propagation plus temporal asynchrony and switch of lateralization. Note the large area involved at the onset of the seizure and the difference in speed in the discharge's propagation to the contralateral hemisphere as compared to Fig. 2. (A–C) Without interruption, (D) 72 s after onset.

Mentions: On Day 8 (Fig. 3), 70 electroclinical seizures were recorded, some with left temporal onset and others with right temporal onset. Six different propagation models were identified: a) some seizures showed regionalized onset in the temporal lobe followed by ipsilateral hemispheric propagation and then switch of lateralization; b) others with regionalized onset showed a switch of lateralization and temporal asynchrony; c) other seizures had a more hemispheric onset with early remote propagation; d) some seizures showed only hemispheric propagation; e) some nonlateralized onset seizures were recorded; and f) bitemporal onset seizures with nonclassifiable propagation models were also recorded.


Changing patterns of propagation in a super-refractory status of the temporal lobe. Over 900 seizures recorded over nearly one year.

Napolitano CE, Orriols MA - Epilepsy Behav Case Rep (2013)

Recording from Day 8: 70 seizures, independent onset in the right and left temporal lobes. Six propagation models (see text). EEG: left temporal onset with early remote propagation plus temporal asynchrony and switch of lateralization. Note the large area involved at the onset of the seizure and the difference in speed in the discharge's propagation to the contralateral hemisphere as compared to Fig. 2. (A–C) Without interruption, (D) 72 s after onset.
© Copyright Policy - CC BY-NC-SA
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150637&req=5

f0015: Recording from Day 8: 70 seizures, independent onset in the right and left temporal lobes. Six propagation models (see text). EEG: left temporal onset with early remote propagation plus temporal asynchrony and switch of lateralization. Note the large area involved at the onset of the seizure and the difference in speed in the discharge's propagation to the contralateral hemisphere as compared to Fig. 2. (A–C) Without interruption, (D) 72 s after onset.
Mentions: On Day 8 (Fig. 3), 70 electroclinical seizures were recorded, some with left temporal onset and others with right temporal onset. Six different propagation models were identified: a) some seizures showed regionalized onset in the temporal lobe followed by ipsilateral hemispheric propagation and then switch of lateralization; b) others with regionalized onset showed a switch of lateralization and temporal asynchrony; c) other seizures had a more hemispheric onset with early remote propagation; d) some seizures showed only hemispheric propagation; e) some nonlateralized onset seizures were recorded; and f) bitemporal onset seizures with nonclassifiable propagation models were also recorded.

Bottom Line: Our goals were to study the propagation models in a situation of persistent temporal epileptic seizures with varying degrees of bitemporal excitability and to analyze which propagation models were found at times of high temporal excitability and which occurred with lower levels of excitability.From the beginning, the interictal recording showed independent discharges over both temporal lobes.The analysis of the propagation models may provide information about the excitability of the mesial temporal-limbic network.

View Article: PubMed Central - PubMed

Affiliation: Neurology Service, Electroencephalography Department, Military Hospital, Santiago, Chile.

ABSTRACT

Objective: Our goals were to study the propagation models in a situation of persistent temporal epileptic seizures with varying degrees of bitemporal excitability and to analyze which propagation models were found at times of high temporal excitability and which occurred with lower levels of excitability.

Methods: A patient with super-refractory status arising from the temporal lobes was studied daily using video-electroencephalography (VEEG), with a large number of electroclinical seizures recorded. The analysis focused on the method and type of seizure propagation and classified them either according to the propagation models described in the literature or as undetermined.

Results: Video-EEG monitoring was carried out daily for 310 days. A total of 990 electroclinical seizures were recorded; 135 seizures were recorded during the first week, and 523 were recorded in the first month. From the beginning, the interictal recording showed independent discharges over both temporal lobes. The seizures showed independent onset in both temporal lobes. During periods of the highest number of seizures, certain models of propagation begin to predominate through switch of lateralization, temporal asynchrony, early remote propagation, total contralateral propagation, seizures with nonlocalized onset, or models that are difficult to classify. Conversely, when the condition was brought relatively under control, we observed fewer propagation models with predominantly simple patterns: only hemispheric propagation or graduated sequential propagation with a few nonlateralized onset seizures.

Conclusions: Upon analyzing the seizures, we found that the propagation models vary as the status evolved, with the change reflecting the degree of excitability in the mesial temporal-limbic network at a given time. In clinical practice, these changes in propagation models are more likely to be observed in temporal status that extends over time and with an onset of the seizures in both temporal lobes.

Significance: The analysis of the propagation models may provide information about the excitability of the mesial temporal-limbic network.

No MeSH data available.


Related in: MedlinePlus