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Age-specific reference ranges of serum prostate-specific antigen in Iraqi men.

Hailan M, Rifat UN - Arab J Urol (2011)

Bottom Line: The results were analysed using descriptive statistics, statistical tables, the arithmetic mean, standard error, standard deviation, and by two extremes.There was a significant increase between the third and fourth group, and all these results were significant at P < 0.001, with the last being more significant.Our result of a PSA maximum at 4.8 ng/mL is slightly more than the international standard threshold of 4.0 ng/mL.

View Article: PubMed Central - PubMed

Affiliation: Medical City Hospital, Baghdad, Iraq.

ABSTRACT

Background: Different races have their own reference ranges of serum prostate-specific antigen (PSA) because of the influence of geographical and ethnic differences. In this study we determined the distribution of serum PSA levels in Iraqi men with no prostate cancer, to our knowledge the first such study from Iraq.

Subjects and methods: From January 2003 to May 2004, in a prospectively designed study, we included 130 Iraqi men aged 20-79 years. The criteria of an elevated PSA level, abnormal ultrasonography results and/or abnormal findings on a digital rectal examination were used to exclude patients from the study. Ethnicity was not recorded, as Iraq has a multi-ethnic status. The results were analysed using descriptive statistics, statistical tables, the arithmetic mean, standard error, standard deviation, and by two extremes.

Results: The PSA values in different age groups (20-29, 30-39, 40-49, 50-59 and 60-79) were, respectively, ⩾0.55 to ⩽1.3, ⩽1.6, ⩽2.0, ⩽4.6 and ⩽4.8 ng/mL. There was a significant increase between the third and fourth group, and all these results were significant at P < 0.001, with the last being more significant.

Conclusion: Serum PSA measurements should be standardized according to country and ethnic groups. Our result of a PSA maximum at 4.8 ng/mL is slightly more than the international standard threshold of 4.0 ng/mL.

No MeSH data available.


Related in: MedlinePlus

Correlation between age and PSA by long-term trend.
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f0020: Correlation between age and PSA by long-term trend.

Mentions: As an initial method for linear regression analysis we used Pearson correlation, which was highly significant (P < 0.001) for increasing age vs. increasing PSA level. These results allowed the use of linear regression analysis between age groups as an independent variable, by PSA indicator as the dependent variable, shown graphically in Fig. 4. There was a highly positive correlation between the variables. The 95% mean prediction intervals (inner and outer lines) show that most points fall inside the interval, except four PSA values in the oldest groups. The prediction linear regression equation is PSA = 0.37 + 0.02 × age (ordinary least-square method). Fig. 4 shows the correlation between age and PSA level by long-term trend.


Age-specific reference ranges of serum prostate-specific antigen in Iraqi men.

Hailan M, Rifat UN - Arab J Urol (2011)

Correlation between age and PSA by long-term trend.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150601&req=5

f0020: Correlation between age and PSA by long-term trend.
Mentions: As an initial method for linear regression analysis we used Pearson correlation, which was highly significant (P < 0.001) for increasing age vs. increasing PSA level. These results allowed the use of linear regression analysis between age groups as an independent variable, by PSA indicator as the dependent variable, shown graphically in Fig. 4. There was a highly positive correlation between the variables. The 95% mean prediction intervals (inner and outer lines) show that most points fall inside the interval, except four PSA values in the oldest groups. The prediction linear regression equation is PSA = 0.37 + 0.02 × age (ordinary least-square method). Fig. 4 shows the correlation between age and PSA level by long-term trend.

Bottom Line: The results were analysed using descriptive statistics, statistical tables, the arithmetic mean, standard error, standard deviation, and by two extremes.There was a significant increase between the third and fourth group, and all these results were significant at P < 0.001, with the last being more significant.Our result of a PSA maximum at 4.8 ng/mL is slightly more than the international standard threshold of 4.0 ng/mL.

View Article: PubMed Central - PubMed

Affiliation: Medical City Hospital, Baghdad, Iraq.

ABSTRACT

Background: Different races have their own reference ranges of serum prostate-specific antigen (PSA) because of the influence of geographical and ethnic differences. In this study we determined the distribution of serum PSA levels in Iraqi men with no prostate cancer, to our knowledge the first such study from Iraq.

Subjects and methods: From January 2003 to May 2004, in a prospectively designed study, we included 130 Iraqi men aged 20-79 years. The criteria of an elevated PSA level, abnormal ultrasonography results and/or abnormal findings on a digital rectal examination were used to exclude patients from the study. Ethnicity was not recorded, as Iraq has a multi-ethnic status. The results were analysed using descriptive statistics, statistical tables, the arithmetic mean, standard error, standard deviation, and by two extremes.

Results: The PSA values in different age groups (20-29, 30-39, 40-49, 50-59 and 60-79) were, respectively, ⩾0.55 to ⩽1.3, ⩽1.6, ⩽2.0, ⩽4.6 and ⩽4.8 ng/mL. There was a significant increase between the third and fourth group, and all these results were significant at P < 0.001, with the last being more significant.

Conclusion: Serum PSA measurements should be standardized according to country and ethnic groups. Our result of a PSA maximum at 4.8 ng/mL is slightly more than the international standard threshold of 4.0 ng/mL.

No MeSH data available.


Related in: MedlinePlus