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Surgical treatment of refractory epilepsy after chemotherapy in two children with leukemia.

Leng Y, Yu T, Li Y, Chen W - Epilepsy Behav Case Rep (2013)

Bottom Line: In these cases, the cause of the refractory seizures was identified as mesial temporal lobe sclerosis.Using presurgical evaluations and measures of the surgical outcomes, the lesions were identified as epileptogenic and were located in the mesial temporal lobe.The underlying pathophysiological background is discussed to aid in understanding this uncommon long-term complication.

View Article: PubMed Central - PubMed

Affiliation: Department of Hematology, Chaoyang Hospital of Capital Medical University, Beijing, China.

ABSTRACT
Refractory epilepsy is a rare, long-term complication in children with acute leukemia who are receiving chemotherapy. A few studies have reported cases of several patients who developed recurrent complex partial seizures after the initiation of chemotherapy. In these cases, the cause of the refractory seizures was identified as mesial temporal lobe sclerosis. Here, we report on two patients with extratemporal lesions accompanied by refractory seizures, a long-term complication of acute lymphocytic leukemia. Using presurgical evaluations and measures of the surgical outcomes, the lesions were identified as epileptogenic and were located in the mesial temporal lobe. The underlying pathophysiological background is discussed to aid in understanding this uncommon long-term complication.

No MeSH data available.


Related in: MedlinePlus

Lesions in the right posterior temporal–parietal region.
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f0020: Lesions in the right posterior temporal–parietal region.

Mentions: His medically refractory epilepsy was surgically evaluated when he was fifteen years old. Interictal scalp EEG recordings revealed right temporal–parietal discharges, and long-term video-EEG monitoring revealed that the seizures originated from the same region. Magnetic resonance imaging scans also showed hippocampal sclerosis on the right side, in addition to the lesion in the right temporal–parietal region (Figs. 4 and 5). Furthermore, the spike dipoles of the magnetoencephalogram were concentrated around the lesion. Therefore, the epileptogenic zone (EZ) was localized in the region of the posterior temporal-parietal lobe. Surgical resection was performed. The resection included both the hippocampus and the posterior temporal lesion. A postoperative histopathological examination revealed severe hippocampal sclerosis and cicatrix gyrus in the resected temporal–parietal tissue. The patient has been seizure-free in the year following the operation and uses the medication oxcarbazepine.


Surgical treatment of refractory epilepsy after chemotherapy in two children with leukemia.

Leng Y, Yu T, Li Y, Chen W - Epilepsy Behav Case Rep (2013)

Lesions in the right posterior temporal–parietal region.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4150597&req=5

f0020: Lesions in the right posterior temporal–parietal region.
Mentions: His medically refractory epilepsy was surgically evaluated when he was fifteen years old. Interictal scalp EEG recordings revealed right temporal–parietal discharges, and long-term video-EEG monitoring revealed that the seizures originated from the same region. Magnetic resonance imaging scans also showed hippocampal sclerosis on the right side, in addition to the lesion in the right temporal–parietal region (Figs. 4 and 5). Furthermore, the spike dipoles of the magnetoencephalogram were concentrated around the lesion. Therefore, the epileptogenic zone (EZ) was localized in the region of the posterior temporal-parietal lobe. Surgical resection was performed. The resection included both the hippocampus and the posterior temporal lesion. A postoperative histopathological examination revealed severe hippocampal sclerosis and cicatrix gyrus in the resected temporal–parietal tissue. The patient has been seizure-free in the year following the operation and uses the medication oxcarbazepine.

Bottom Line: In these cases, the cause of the refractory seizures was identified as mesial temporal lobe sclerosis.Using presurgical evaluations and measures of the surgical outcomes, the lesions were identified as epileptogenic and were located in the mesial temporal lobe.The underlying pathophysiological background is discussed to aid in understanding this uncommon long-term complication.

View Article: PubMed Central - PubMed

Affiliation: Department of Hematology, Chaoyang Hospital of Capital Medical University, Beijing, China.

ABSTRACT
Refractory epilepsy is a rare, long-term complication in children with acute leukemia who are receiving chemotherapy. A few studies have reported cases of several patients who developed recurrent complex partial seizures after the initiation of chemotherapy. In these cases, the cause of the refractory seizures was identified as mesial temporal lobe sclerosis. Here, we report on two patients with extratemporal lesions accompanied by refractory seizures, a long-term complication of acute lymphocytic leukemia. Using presurgical evaluations and measures of the surgical outcomes, the lesions were identified as epileptogenic and were located in the mesial temporal lobe. The underlying pathophysiological background is discussed to aid in understanding this uncommon long-term complication.

No MeSH data available.


Related in: MedlinePlus