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Long-term outcome of grafts with multiple arteries in live-donor renal allotransplantation: Analysis of 2100 consecutive patients.

Soliman SA, Shokeir AA, Kamal AI, El-Hefnawy AS, Harraz AM, Kamal MM, Osman Y, Ali El-Dein B, Shehab El-Dein AB, Ghoneim MA - Arab J Urol (2011)

Bottom Line: Vascular thrombosis (arterial and venous) had a higher incidence in MGA (2.5%) than SGA (0.6%) (P = 0.01).Both groups were not significantly different for the onset of diuresis, acute rejection and urological complications (P = 0.16, 0.23 and 0.85, respectively).The early, intermediate- and long-term follow-up showed an outcome comparable to that in patients with SGA.

View Article: PubMed Central - PubMed

Affiliation: Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.

ABSTRACT

Purpose: To analyse the long-term outcome in relation to multiple graft arteries (MGA) in live-donor renal transplantation, and assess its effect on graft and patient survival.

Patients and methods: Between March 1976 and November 2009, a total of 2100 live-donor renal transplants were carried out at our centre. Patients were stratified according to the number of graft arteries into two groups, i.e. MGA (two or more arteries; 237 patients) and single-graft artery (SGA; 1863 patients). Variables assessed included patient demographics, site of vascular anastomosis, ischaemia time, onset of diuresis, delayed graft function, acute tubular necrosis (ATN), acute rejection, vascular and urological complications. Moreover, long-term patient and graft survival were compared among both groups. Patients were followed up for a mean (SD) of 112 (63) months.

Results: Grafts with MGA were associated with a prolonged ischaemia time (P = 0.001) and ATN (P = 0.005). Vascular thrombosis (arterial and venous) had a higher incidence in MGA (2.5%) than SGA (0.6%) (P = 0.01). Both groups were not significantly different for the onset of diuresis, acute rejection and urological complications (P = 0.16, 0.23 and 0.85, respectively). Graft and patient survival were comparable in both groups. The mean (SD) 1-, 5-, 10- and 20-year graft survival rates (%) for MGA were 96.1 (1.26), 86.6 (2.39), 61.3 (4.42) and 33.8 (7.23), and 97.5 (0.36), 86.8 (0.84), 66.0 (1.35) and 37.3 (2.76) for SGA (P = 0.54).

Conclusions: Although there was a higher incidence of prolonged ischaemia time, ATN and vascular thrombosis in live-donor renal transplants with MGA, it did not adversely affect patient or graft survival. The early, intermediate- and long-term follow-up showed an outcome comparable to that in patients with SGA.

No MeSH data available.


Related in: MedlinePlus

Graft (A) and patient (B) survival rates in patients with SGA or MGA (P = 0.54 and 0.98, respectively).
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f0005: Graft (A) and patient (B) survival rates in patients with SGA or MGA (P = 0.54 and 0.98, respectively).

Mentions: The early-, intermediate- and long-term graft and patient survival were comparable among patients of both groups. The 1-, 5-, 10- and 20-year graft and patient survival rates in the two groups are shown in Table 5 and Fig. 1A and B.


Long-term outcome of grafts with multiple arteries in live-donor renal allotransplantation: Analysis of 2100 consecutive patients.

Soliman SA, Shokeir AA, Kamal AI, El-Hefnawy AS, Harraz AM, Kamal MM, Osman Y, Ali El-Dein B, Shehab El-Dein AB, Ghoneim MA - Arab J Urol (2011)

Graft (A) and patient (B) survival rates in patients with SGA or MGA (P = 0.54 and 0.98, respectively).
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150580&req=5

f0005: Graft (A) and patient (B) survival rates in patients with SGA or MGA (P = 0.54 and 0.98, respectively).
Mentions: The early-, intermediate- and long-term graft and patient survival were comparable among patients of both groups. The 1-, 5-, 10- and 20-year graft and patient survival rates in the two groups are shown in Table 5 and Fig. 1A and B.

Bottom Line: Vascular thrombosis (arterial and venous) had a higher incidence in MGA (2.5%) than SGA (0.6%) (P = 0.01).Both groups were not significantly different for the onset of diuresis, acute rejection and urological complications (P = 0.16, 0.23 and 0.85, respectively).The early, intermediate- and long-term follow-up showed an outcome comparable to that in patients with SGA.

View Article: PubMed Central - PubMed

Affiliation: Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.

ABSTRACT

Purpose: To analyse the long-term outcome in relation to multiple graft arteries (MGA) in live-donor renal transplantation, and assess its effect on graft and patient survival.

Patients and methods: Between March 1976 and November 2009, a total of 2100 live-donor renal transplants were carried out at our centre. Patients were stratified according to the number of graft arteries into two groups, i.e. MGA (two or more arteries; 237 patients) and single-graft artery (SGA; 1863 patients). Variables assessed included patient demographics, site of vascular anastomosis, ischaemia time, onset of diuresis, delayed graft function, acute tubular necrosis (ATN), acute rejection, vascular and urological complications. Moreover, long-term patient and graft survival were compared among both groups. Patients were followed up for a mean (SD) of 112 (63) months.

Results: Grafts with MGA were associated with a prolonged ischaemia time (P = 0.001) and ATN (P = 0.005). Vascular thrombosis (arterial and venous) had a higher incidence in MGA (2.5%) than SGA (0.6%) (P = 0.01). Both groups were not significantly different for the onset of diuresis, acute rejection and urological complications (P = 0.16, 0.23 and 0.85, respectively). Graft and patient survival were comparable in both groups. The mean (SD) 1-, 5-, 10- and 20-year graft survival rates (%) for MGA were 96.1 (1.26), 86.6 (2.39), 61.3 (4.42) and 33.8 (7.23), and 97.5 (0.36), 86.8 (0.84), 66.0 (1.35) and 37.3 (2.76) for SGA (P = 0.54).

Conclusions: Although there was a higher incidence of prolonged ischaemia time, ATN and vascular thrombosis in live-donor renal transplants with MGA, it did not adversely affect patient or graft survival. The early, intermediate- and long-term follow-up showed an outcome comparable to that in patients with SGA.

No MeSH data available.


Related in: MedlinePlus