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Induced urinary crystal formation as an analytical strategy for the prediction and monitoring of urolithiasis and other metabolism-related disorders.

Laube N, Berg W, Bernsmann F, Gravius S, Klein F, Latz S, Mallek Dv, Porowski T, Randau T, Wasilewska A, Fisang C - EPMA J (2014)

Bottom Line: In case of urolithiasis, induced crystal formation in native urine has led to the development of the Bonn-Risk-Index (BRI), a valuable tool to quantify an individual's risk of calcium oxalate urolithiasis.If the progression of a disease is associated with characteristic changes in the activities of urinary components, this leads to an altered urinary crystallisation capacity.Since crystal formation inherently takes into account the entire urinary composition, the influence of the disease on individual urinary parameters does not have to be known in order to monitor the consequent pathologic alterations.

View Article: PubMed Central - HTML - PubMed

Affiliation: Deutsches Harnsteinzentrum, Urologisches Zentrum Bonn Friedensplatz, Friedensplatz 16, Bonn 53111, Germany ; NTTF Coatings GmbH, Maarweg 32, Rheinbreitbach 53619, Germany.

ABSTRACT
Crystal formation reflects the entire composition of the surrounding solution. In case of urolithiasis, induced crystal formation in native urine has led to the development of the Bonn-Risk-Index (BRI), a valuable tool to quantify an individual's risk of calcium oxalate urolithiasis. If the progression of a disease is associated with characteristic changes in the activities of urinary components, this leads to an altered urinary crystallisation capacity. Therefore, the results of induced urinary crystal formation can be used to detect and monitor any disease linked to the altered urinary composition. Since crystal formation inherently takes into account the entire urinary composition, the influence of the disease on individual urinary parameters does not have to be known in order to monitor the consequent pathologic alterations. In this paper, we review the background of urinary crystal formation analysis and describe its established application in urolithiasis monitoring as well as potential further fields of clinical application.

No MeSH data available.


Related in: MedlinePlus

The role of the BRI-test in the prevention of recurrent stone formation. Left: The vicious circle of recurrent stone formation as a result of lacking metaphylactic measures. Right: The BRI has been proven to be a straightforward and intuitive diagnostic tool helping to escape from therapeutic undersupply and to achieve health and therapy control.
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Figure 7: The role of the BRI-test in the prevention of recurrent stone formation. Left: The vicious circle of recurrent stone formation as a result of lacking metaphylactic measures. Right: The BRI has been proven to be a straightforward and intuitive diagnostic tool helping to escape from therapeutic undersupply and to achieve health and therapy control.

Mentions: The BRI has proven its qualities as a diagnostic tool in the treatment of calcium oxalate urolithiasis. Urolithiasis is a widespread ailment in developed countries with current prevalence rates above 5%. Stone formation is the result of an altered urinary composition, mostly caused by a congenital or acquired underlying metabolic disease (or at least a predisposition to it) and by triggering exogenous risk factors. This makes the pathogenesis in each patient unique and diagnosis, causal treatment and therapeutic monitoring difficult, costly and time-consuming. Routine diagnostic workup is characterised by a lack of analytical results easy to interpret for clinical decision-making and by weak financial incentives. The consequence is a diagnostic and therapeutic undersupply, which inevitably results in a vicious circle of recurrent stone formation, although the recurrence rate can be lowered from 80% without metaphylaxis down to 20% under risk-adopted therapy (FigureĀ 7).


Induced urinary crystal formation as an analytical strategy for the prediction and monitoring of urolithiasis and other metabolism-related disorders.

Laube N, Berg W, Bernsmann F, Gravius S, Klein F, Latz S, Mallek Dv, Porowski T, Randau T, Wasilewska A, Fisang C - EPMA J (2014)

The role of the BRI-test in the prevention of recurrent stone formation. Left: The vicious circle of recurrent stone formation as a result of lacking metaphylactic measures. Right: The BRI has been proven to be a straightforward and intuitive diagnostic tool helping to escape from therapeutic undersupply and to achieve health and therapy control.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4150547&req=5

Figure 7: The role of the BRI-test in the prevention of recurrent stone formation. Left: The vicious circle of recurrent stone formation as a result of lacking metaphylactic measures. Right: The BRI has been proven to be a straightforward and intuitive diagnostic tool helping to escape from therapeutic undersupply and to achieve health and therapy control.
Mentions: The BRI has proven its qualities as a diagnostic tool in the treatment of calcium oxalate urolithiasis. Urolithiasis is a widespread ailment in developed countries with current prevalence rates above 5%. Stone formation is the result of an altered urinary composition, mostly caused by a congenital or acquired underlying metabolic disease (or at least a predisposition to it) and by triggering exogenous risk factors. This makes the pathogenesis in each patient unique and diagnosis, causal treatment and therapeutic monitoring difficult, costly and time-consuming. Routine diagnostic workup is characterised by a lack of analytical results easy to interpret for clinical decision-making and by weak financial incentives. The consequence is a diagnostic and therapeutic undersupply, which inevitably results in a vicious circle of recurrent stone formation, although the recurrence rate can be lowered from 80% without metaphylaxis down to 20% under risk-adopted therapy (FigureĀ 7).

Bottom Line: In case of urolithiasis, induced crystal formation in native urine has led to the development of the Bonn-Risk-Index (BRI), a valuable tool to quantify an individual's risk of calcium oxalate urolithiasis.If the progression of a disease is associated with characteristic changes in the activities of urinary components, this leads to an altered urinary crystallisation capacity.Since crystal formation inherently takes into account the entire urinary composition, the influence of the disease on individual urinary parameters does not have to be known in order to monitor the consequent pathologic alterations.

View Article: PubMed Central - HTML - PubMed

Affiliation: Deutsches Harnsteinzentrum, Urologisches Zentrum Bonn Friedensplatz, Friedensplatz 16, Bonn 53111, Germany ; NTTF Coatings GmbH, Maarweg 32, Rheinbreitbach 53619, Germany.

ABSTRACT
Crystal formation reflects the entire composition of the surrounding solution. In case of urolithiasis, induced crystal formation in native urine has led to the development of the Bonn-Risk-Index (BRI), a valuable tool to quantify an individual's risk of calcium oxalate urolithiasis. If the progression of a disease is associated with characteristic changes in the activities of urinary components, this leads to an altered urinary crystallisation capacity. Therefore, the results of induced urinary crystal formation can be used to detect and monitor any disease linked to the altered urinary composition. Since crystal formation inherently takes into account the entire urinary composition, the influence of the disease on individual urinary parameters does not have to be known in order to monitor the consequent pathologic alterations. In this paper, we review the background of urinary crystal formation analysis and describe its established application in urolithiasis monitoring as well as potential further fields of clinical application.

No MeSH data available.


Related in: MedlinePlus