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Shear wave elastography: a new noninvasive tool to assess the intensity of fibrosis of irradiated salivary glands in head and neck cancer patients.

Kałużny J, Kopeć T, Szczepanek-Parulska E, Stangierski A, Gurgul E, Ruchała M, Milecki P, Wierzbicka M - Biomed Res Int (2014)

Bottom Line: All of the former were treated for advanced larynx (40), oropharynx (9), or maxilla (3) squamous cancers and suffered from chronic dryness.There was a statistical difference between ES values in the RT group and in the controls for parotid glands (41.7 kPa versus 26.03 kPa, P = 0.0018) and for submandibular glands (37.6 kPa versus 22.4 kPa; P = 0.005).There was a significant correlation between the CTCAE scores and objective saliva amount (P = 0.0005), and the median amount of saliva in the examined group was lower than in the reference group (1.86 g versus 2.75 g, P = 0.0006).

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology, Head and Neck Surgery, Poznan University of Medical Sciences, 49 Przybyszewskiego Street, 60-355 Poznan, Poland.

ABSTRACT
The aim of the study was to assess salivary gland parenchyma by means of sonoelastography in patients irradiated for head and neck squamous cell carcinoma (HNSCC). The studied group consisted of 52 patients after radiotherapy (RT) and 54 healthy volunteers. All of the former were treated for advanced larynx (40), oropharynx (9), or maxilla (3) squamous cancers and suffered from chronic dryness. Ultrasonography (US) and elastography (ES) were performed, as well as an assessment of the amount of saliva and Common Terminology Criteria for Adverse Events (CTCAE) scale. There was a statistical difference between ES values in the RT group and in the controls for parotid glands (41.7 kPa versus 26.03 kPa, P = 0.0018) and for submandibular glands (37.6 kPa versus 22.4 kPa; P = 0.005). There was a significant correlation between the CTCAE scores and objective saliva amount (P = 0.0005), and the median amount of saliva in the examined group was lower than in the reference group (1.86 g versus 2.75 g, P = 0.0006). In conclusion sonoelastography adds a new parameter to ultrasonography in "one touch examination" and may be a useful tool for major salivary gland evaluation during the radiotherapy course and follow-up period.

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Related in: MedlinePlus

Sonoelastography picture: irradiated parotid gland tissue is marked in the green pattern, which confirms parenchyma high stiffness.
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fig2: Sonoelastography picture: irradiated parotid gland tissue is marked in the green pattern, which confirms parenchyma high stiffness.

Mentions: There was a statistical difference between elastography values in the irradiated group and in controls in terms of parotid glands (41.7 kPa versus 26.0 kPa; P = 0.0018) and submandibular glands (37.6 kPa versus 22.4 kPa; P = 0.005). Sonoelastography results of 52 HNSCC patients after RT are shown in Table 1. The values in kPa were taken from the 3 different areas of parenchyma. The values ranged from 4 kPa to 160 kPa. In fact they differed dramatically, although the parenchyma was sonographically isoechogenic. The mean and the median values of the changed parenchyma for the whole group (representing the average highest stiffness value) were 39.6 kPa and 34.9 kPa, respectively; these two variables were taken into consideration in further analysis. The mean and the median value for both parotid glands in the examined group were 41.7 kPa and 40 kPa (Figure 2), while for both submandibular glands they were 37.6 kPa and 34.5 kPa, respectively.


Shear wave elastography: a new noninvasive tool to assess the intensity of fibrosis of irradiated salivary glands in head and neck cancer patients.

Kałużny J, Kopeć T, Szczepanek-Parulska E, Stangierski A, Gurgul E, Ruchała M, Milecki P, Wierzbicka M - Biomed Res Int (2014)

Sonoelastography picture: irradiated parotid gland tissue is marked in the green pattern, which confirms parenchyma high stiffness.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150524&req=5

fig2: Sonoelastography picture: irradiated parotid gland tissue is marked in the green pattern, which confirms parenchyma high stiffness.
Mentions: There was a statistical difference between elastography values in the irradiated group and in controls in terms of parotid glands (41.7 kPa versus 26.0 kPa; P = 0.0018) and submandibular glands (37.6 kPa versus 22.4 kPa; P = 0.005). Sonoelastography results of 52 HNSCC patients after RT are shown in Table 1. The values in kPa were taken from the 3 different areas of parenchyma. The values ranged from 4 kPa to 160 kPa. In fact they differed dramatically, although the parenchyma was sonographically isoechogenic. The mean and the median values of the changed parenchyma for the whole group (representing the average highest stiffness value) were 39.6 kPa and 34.9 kPa, respectively; these two variables were taken into consideration in further analysis. The mean and the median value for both parotid glands in the examined group were 41.7 kPa and 40 kPa (Figure 2), while for both submandibular glands they were 37.6 kPa and 34.5 kPa, respectively.

Bottom Line: All of the former were treated for advanced larynx (40), oropharynx (9), or maxilla (3) squamous cancers and suffered from chronic dryness.There was a statistical difference between ES values in the RT group and in the controls for parotid glands (41.7 kPa versus 26.03 kPa, P = 0.0018) and for submandibular glands (37.6 kPa versus 22.4 kPa; P = 0.005).There was a significant correlation between the CTCAE scores and objective saliva amount (P = 0.0005), and the median amount of saliva in the examined group was lower than in the reference group (1.86 g versus 2.75 g, P = 0.0006).

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology, Head and Neck Surgery, Poznan University of Medical Sciences, 49 Przybyszewskiego Street, 60-355 Poznan, Poland.

ABSTRACT
The aim of the study was to assess salivary gland parenchyma by means of sonoelastography in patients irradiated for head and neck squamous cell carcinoma (HNSCC). The studied group consisted of 52 patients after radiotherapy (RT) and 54 healthy volunteers. All of the former were treated for advanced larynx (40), oropharynx (9), or maxilla (3) squamous cancers and suffered from chronic dryness. Ultrasonography (US) and elastography (ES) were performed, as well as an assessment of the amount of saliva and Common Terminology Criteria for Adverse Events (CTCAE) scale. There was a statistical difference between ES values in the RT group and in the controls for parotid glands (41.7 kPa versus 26.03 kPa, P = 0.0018) and for submandibular glands (37.6 kPa versus 22.4 kPa; P = 0.005). There was a significant correlation between the CTCAE scores and objective saliva amount (P = 0.0005), and the median amount of saliva in the examined group was lower than in the reference group (1.86 g versus 2.75 g, P = 0.0006). In conclusion sonoelastography adds a new parameter to ultrasonography in "one touch examination" and may be a useful tool for major salivary gland evaluation during the radiotherapy course and follow-up period.

Show MeSH
Related in: MedlinePlus