Limits...
Shear wave elastography: a new noninvasive tool to assess the intensity of fibrosis of irradiated salivary glands in head and neck cancer patients.

Kałużny J, Kopeć T, Szczepanek-Parulska E, Stangierski A, Gurgul E, Ruchała M, Milecki P, Wierzbicka M - Biomed Res Int (2014)

Bottom Line: All of the former were treated for advanced larynx (40), oropharynx (9), or maxilla (3) squamous cancers and suffered from chronic dryness.There was a statistical difference between ES values in the RT group and in the controls for parotid glands (41.7 kPa versus 26.03 kPa, P = 0.0018) and for submandibular glands (37.6 kPa versus 22.4 kPa; P = 0.005).There was a significant correlation between the CTCAE scores and objective saliva amount (P = 0.0005), and the median amount of saliva in the examined group was lower than in the reference group (1.86 g versus 2.75 g, P = 0.0006).

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology, Head and Neck Surgery, Poznan University of Medical Sciences, 49 Przybyszewskiego Street, 60-355 Poznan, Poland.

ABSTRACT
The aim of the study was to assess salivary gland parenchyma by means of sonoelastography in patients irradiated for head and neck squamous cell carcinoma (HNSCC). The studied group consisted of 52 patients after radiotherapy (RT) and 54 healthy volunteers. All of the former were treated for advanced larynx (40), oropharynx (9), or maxilla (3) squamous cancers and suffered from chronic dryness. Ultrasonography (US) and elastography (ES) were performed, as well as an assessment of the amount of saliva and Common Terminology Criteria for Adverse Events (CTCAE) scale. There was a statistical difference between ES values in the RT group and in the controls for parotid glands (41.7 kPa versus 26.03 kPa, P = 0.0018) and for submandibular glands (37.6 kPa versus 22.4 kPa; P = 0.005). There was a significant correlation between the CTCAE scores and objective saliva amount (P = 0.0005), and the median amount of saliva in the examined group was lower than in the reference group (1.86 g versus 2.75 g, P = 0.0006). In conclusion sonoelastography adds a new parameter to ultrasonography in "one touch examination" and may be a useful tool for major salivary gland evaluation during the radiotherapy course and follow-up period.

Show MeSH

Related in: MedlinePlus

Sonoelastography picture: normal parotid gland tissue is marked as blue, which confirms parenchyma low stiffness.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4150524&req=5

fig1: Sonoelastography picture: normal parotid gland tissue is marked as blue, which confirms parenchyma low stiffness.

Mentions: Ultrasonography and sonoelastography as a real time “one touch examination” using Aixplorer (SuperSonic Imagine) were performed. Two operators with four years' experience in the technique conducted the examination. The patients were examined in the supine position. Transverse scans of salivary glands were acquired. A high resolution grey scale US 5–15 MHz linear array transducer was placed both in the middle of the unaffected gland and in heterogenic areas, in the case of alterations in the US picture. Elasticity values in kiloPascal's (kPa) were collected; the minimum, maximum, and mean values at 3 measurement points in different parts of the glands were taken (Figure 1). The US images were categorized as isoechogenic (50 patients) and with marked fibrosis (2 patients).


Shear wave elastography: a new noninvasive tool to assess the intensity of fibrosis of irradiated salivary glands in head and neck cancer patients.

Kałużny J, Kopeć T, Szczepanek-Parulska E, Stangierski A, Gurgul E, Ruchała M, Milecki P, Wierzbicka M - Biomed Res Int (2014)

Sonoelastography picture: normal parotid gland tissue is marked as blue, which confirms parenchyma low stiffness.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150524&req=5

fig1: Sonoelastography picture: normal parotid gland tissue is marked as blue, which confirms parenchyma low stiffness.
Mentions: Ultrasonography and sonoelastography as a real time “one touch examination” using Aixplorer (SuperSonic Imagine) were performed. Two operators with four years' experience in the technique conducted the examination. The patients were examined in the supine position. Transverse scans of salivary glands were acquired. A high resolution grey scale US 5–15 MHz linear array transducer was placed both in the middle of the unaffected gland and in heterogenic areas, in the case of alterations in the US picture. Elasticity values in kiloPascal's (kPa) were collected; the minimum, maximum, and mean values at 3 measurement points in different parts of the glands were taken (Figure 1). The US images were categorized as isoechogenic (50 patients) and with marked fibrosis (2 patients).

Bottom Line: All of the former were treated for advanced larynx (40), oropharynx (9), or maxilla (3) squamous cancers and suffered from chronic dryness.There was a statistical difference between ES values in the RT group and in the controls for parotid glands (41.7 kPa versus 26.03 kPa, P = 0.0018) and for submandibular glands (37.6 kPa versus 22.4 kPa; P = 0.005).There was a significant correlation between the CTCAE scores and objective saliva amount (P = 0.0005), and the median amount of saliva in the examined group was lower than in the reference group (1.86 g versus 2.75 g, P = 0.0006).

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology, Head and Neck Surgery, Poznan University of Medical Sciences, 49 Przybyszewskiego Street, 60-355 Poznan, Poland.

ABSTRACT
The aim of the study was to assess salivary gland parenchyma by means of sonoelastography in patients irradiated for head and neck squamous cell carcinoma (HNSCC). The studied group consisted of 52 patients after radiotherapy (RT) and 54 healthy volunteers. All of the former were treated for advanced larynx (40), oropharynx (9), or maxilla (3) squamous cancers and suffered from chronic dryness. Ultrasonography (US) and elastography (ES) were performed, as well as an assessment of the amount of saliva and Common Terminology Criteria for Adverse Events (CTCAE) scale. There was a statistical difference between ES values in the RT group and in the controls for parotid glands (41.7 kPa versus 26.03 kPa, P = 0.0018) and for submandibular glands (37.6 kPa versus 22.4 kPa; P = 0.005). There was a significant correlation between the CTCAE scores and objective saliva amount (P = 0.0005), and the median amount of saliva in the examined group was lower than in the reference group (1.86 g versus 2.75 g, P = 0.0006). In conclusion sonoelastography adds a new parameter to ultrasonography in "one touch examination" and may be a useful tool for major salivary gland evaluation during the radiotherapy course and follow-up period.

Show MeSH
Related in: MedlinePlus