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Synchronous gastric gastrointestinal stromal tumor and colon adenocarcinoma: a case report.

Vasilakaki T, Koulia K, Tsavari A, Arkoumani E, Kouroumpas E, Pavlis A, Christopoulos G, Stamatiou K, Manoloudaki K, Zisis D - Case Rep Oncol Med (2014)

Bottom Line: Pathologic examination of the ascending colon mass showed an invasive moderately differentiated adenocarcinoma stage III B (T3N1M0).The patient did not receive additional treatment.Two years later the patient showed no evidence of recurrence or metastasis.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, "Tzaneion" General Hospital of Piraeus, 1 Afendouli Avenue, 18536 Piraeus, Greece.

ABSTRACT
Gastrointestinal stromal tumors (GISTs) represent the majority of primary mesenchymal tumors of the gastrointestinal tract. They are generally considered to be solitary tumors and therefore the synchronous occurrence with other primary malignancies of gastrointestinal track is considered a rare event. Here we present the case of a 75-year-old man admitted to our hospital with a 10-day history of gastrointestinal bleeding. Colonoscopy revealed an ulcerative mass of 4 cm in diameter in the ascending colon. Gastroscopy revealed a bulge in the gastric body measuring 1 cm in diameter with normal overlying mucosa. Surgical intervention was suggested and ileohemicolectomy with regional lymph node resection along with gastric wedge resection was performed. Pathologic examination of the ascending colon mass showed an invasive moderately differentiated adenocarcinoma stage III B (T3N1M0). Grossly resected wedge of stomach showed a well circumscribed intramural tumor which microscopically was consistent with essentially benign gastrointestinal stromal tumor (according to Miettinen criteria). The patient did not receive additional treatment. Two years later the patient showed no evidence of recurrence or metastasis.

No MeSH data available.


Related in: MedlinePlus

Gastric GIST, CD117 positive (×100).
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Related In: Results  -  Collection


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fig3: Gastric GIST, CD117 positive (×100).

Mentions: Grossly resected wedge of stomach showed a well circumscribed intramural tumor which microscopically was consistent with an essentially benign gastrointestinal stromal tumor (according to Miettinen criteria). The lesion involved the muscularis propria with variable submucosal extension (Figure 2). The immunohistochemical study showed that the tumor's cells were positive for CD117 and CD34 and negative for actin, desmin, and S100p (Figure 3). The Ki67 labelling index was very low. The mitotic activity was <1 mitosis/50 high power field (HPF). The patient did not receive additional treatment and he was monitored with annual abdominal CT. Two years later the patient showed no evidence of recurrence or metastasis.


Synchronous gastric gastrointestinal stromal tumor and colon adenocarcinoma: a case report.

Vasilakaki T, Koulia K, Tsavari A, Arkoumani E, Kouroumpas E, Pavlis A, Christopoulos G, Stamatiou K, Manoloudaki K, Zisis D - Case Rep Oncol Med (2014)

Gastric GIST, CD117 positive (×100).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4150523&req=5

fig3: Gastric GIST, CD117 positive (×100).
Mentions: Grossly resected wedge of stomach showed a well circumscribed intramural tumor which microscopically was consistent with an essentially benign gastrointestinal stromal tumor (according to Miettinen criteria). The lesion involved the muscularis propria with variable submucosal extension (Figure 2). The immunohistochemical study showed that the tumor's cells were positive for CD117 and CD34 and negative for actin, desmin, and S100p (Figure 3). The Ki67 labelling index was very low. The mitotic activity was <1 mitosis/50 high power field (HPF). The patient did not receive additional treatment and he was monitored with annual abdominal CT. Two years later the patient showed no evidence of recurrence or metastasis.

Bottom Line: Pathologic examination of the ascending colon mass showed an invasive moderately differentiated adenocarcinoma stage III B (T3N1M0).The patient did not receive additional treatment.Two years later the patient showed no evidence of recurrence or metastasis.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, "Tzaneion" General Hospital of Piraeus, 1 Afendouli Avenue, 18536 Piraeus, Greece.

ABSTRACT
Gastrointestinal stromal tumors (GISTs) represent the majority of primary mesenchymal tumors of the gastrointestinal tract. They are generally considered to be solitary tumors and therefore the synchronous occurrence with other primary malignancies of gastrointestinal track is considered a rare event. Here we present the case of a 75-year-old man admitted to our hospital with a 10-day history of gastrointestinal bleeding. Colonoscopy revealed an ulcerative mass of 4 cm in diameter in the ascending colon. Gastroscopy revealed a bulge in the gastric body measuring 1 cm in diameter with normal overlying mucosa. Surgical intervention was suggested and ileohemicolectomy with regional lymph node resection along with gastric wedge resection was performed. Pathologic examination of the ascending colon mass showed an invasive moderately differentiated adenocarcinoma stage III B (T3N1M0). Grossly resected wedge of stomach showed a well circumscribed intramural tumor which microscopically was consistent with essentially benign gastrointestinal stromal tumor (according to Miettinen criteria). The patient did not receive additional treatment. Two years later the patient showed no evidence of recurrence or metastasis.

No MeSH data available.


Related in: MedlinePlus