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Relationship between the Prevalence of Thyroid Nodules and Metabolic Syndrome in the Iodine-Adequate Area of Hangzhou, China: A Cross-Sectional and Cohort Study.

Yin J, Wang C, Shao Q, Qu D, Song Z, Shan P, Zhang T, Xu J, Liang Q, Zhang S, Huang J - Int J Endocrinol (2014)

Bottom Line: Individuals with greater WC in 2009 were more likely to suffer from TN in 2012 (RR = 1.434, P = 0.024).Conclusion.Both greater WC and elevated triglycerides are risk factors for new TN in this iodine-adequate area in China.

View Article: PubMed Central - PubMed

Affiliation: Department of International Health Care Center, The Second Affiliated Hospital ZheJiang University College of Medicine, Hangzhou, Zhejiang 310009, China.

ABSTRACT
Objective. The association between thyroid nodule (TN) prevalence and metabolic syndrome (MetS) has only rarely been examined in iodine-adequate areas and needs further clarification. We investigated correlations between MetS and TN prevalence in the iodine-adequate area of Hangzhou, China. Material and Method. A cross-sectional study that screened and recruited individuals for cohort research 3 years later. The 13522 subjects (8926 men, 4596 women) were screened in 2009 for all MetS components, thyroid ultrasound (US), and thyroid function. Cohort research recruited 1610 subjects who were screened in both 2009 and 2012, of whom 1061 underwent follow-up research. Results. The prevalence of TN was higher in the MetS (+) group than in the MetS (-) group (χ (2) = 69.63, P < 0.001) and higher in women than in men (χ (2) = 11.65, P = 0.001). Waist circumference (WC) was positively related to the prevalence of TN (OR = 1.022, P < 0.001). Individuals with greater WC in 2009 were more likely to suffer from TN in 2012 (RR = 1.434, P = 0.024). Elevated triglyceride level was a risk factor for developing new TN (RR = 1.001, P = 0.035). Conclusion. Both greater WC and elevated triglycerides are risk factors for new TN in this iodine-adequate area in China.

No MeSH data available.


Related in: MedlinePlus

Prevalence of thyroid nodules. (a) The prevalence of thyroid nodules for women was significantly higher than for men in the 40 to 49 age range, 50 to 59 age range, and the age above 70 (χ2 = 8.904, P = 0.003; χ2 = 29.044, P < 0.001; χ2 = 4.631, P = 0.031, respectively). The prevalence of thyroid nodules increased along with increasing age (trend χ2 test: χ2 = 515.22 for men, P < 0.001; χ2 = 921.56 for women, P < 0.001). (b) The prevalence of thyroid nodule in the MetS (+) group was higher than in the MetS (−) group for both sexes together (41.71% (1157/2774) versus 33.23% (3572/10748), χ2 = 69.63, P < 0.001) and for men and women separately (female: 48.15% (260/540) versus 35.43% (1437/4056), χ2 = 33.10, P < 0.001; male: 40.15% (897/2234) versus 31.90% (2135/6692), χ2 = 50.80, P < 0.001).
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fig1: Prevalence of thyroid nodules. (a) The prevalence of thyroid nodules for women was significantly higher than for men in the 40 to 49 age range, 50 to 59 age range, and the age above 70 (χ2 = 8.904, P = 0.003; χ2 = 29.044, P < 0.001; χ2 = 4.631, P = 0.031, respectively). The prevalence of thyroid nodules increased along with increasing age (trend χ2 test: χ2 = 515.22 for men, P < 0.001; χ2 = 921.56 for women, P < 0.001). (b) The prevalence of thyroid nodule in the MetS (+) group was higher than in the MetS (−) group for both sexes together (41.71% (1157/2774) versus 33.23% (3572/10748), χ2 = 69.63, P < 0.001) and for men and women separately (female: 48.15% (260/540) versus 35.43% (1437/4056), χ2 = 33.10, P < 0.001; male: 40.15% (897/2234) versus 31.90% (2135/6692), χ2 = 50.80, P < 0.001).

Mentions: The study population characteristics are depicted in Figure 1(a). As noted, the cross-sectional study included a total of 13522 participants (8926 men and 4596 women). The prevalence of TN was 34.97% (33.97% for men and 36.92% for women). The standardized morbidity rate of TN was 33.70% (31.82% for men and 35.35% for women), which was calculated from the population distribution in China in 2009. The prevalence of TN for women was statistically higher than for men in the age ranges 40 to 59 and >70 and was significantly higher in the age range 50 to 59 (49.54% versus 40.04%, χ2 = 29.044, P < 0.001), and so was the prevalence over all ages (χ2 = 11.651, P = 0.001). Furthermore, the prevalence of TN increased along with increased age (trend χ2 test: χ2 = 1200.33 for both sexes, P < 0.001; χ2 = 515.22 for men, P < 0.001; χ2 = 921.56 for women, P < 0.001).


Relationship between the Prevalence of Thyroid Nodules and Metabolic Syndrome in the Iodine-Adequate Area of Hangzhou, China: A Cross-Sectional and Cohort Study.

Yin J, Wang C, Shao Q, Qu D, Song Z, Shan P, Zhang T, Xu J, Liang Q, Zhang S, Huang J - Int J Endocrinol (2014)

Prevalence of thyroid nodules. (a) The prevalence of thyroid nodules for women was significantly higher than for men in the 40 to 49 age range, 50 to 59 age range, and the age above 70 (χ2 = 8.904, P = 0.003; χ2 = 29.044, P < 0.001; χ2 = 4.631, P = 0.031, respectively). The prevalence of thyroid nodules increased along with increasing age (trend χ2 test: χ2 = 515.22 for men, P < 0.001; χ2 = 921.56 for women, P < 0.001). (b) The prevalence of thyroid nodule in the MetS (+) group was higher than in the MetS (−) group for both sexes together (41.71% (1157/2774) versus 33.23% (3572/10748), χ2 = 69.63, P < 0.001) and for men and women separately (female: 48.15% (260/540) versus 35.43% (1437/4056), χ2 = 33.10, P < 0.001; male: 40.15% (897/2234) versus 31.90% (2135/6692), χ2 = 50.80, P < 0.001).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4150509&req=5

fig1: Prevalence of thyroid nodules. (a) The prevalence of thyroid nodules for women was significantly higher than for men in the 40 to 49 age range, 50 to 59 age range, and the age above 70 (χ2 = 8.904, P = 0.003; χ2 = 29.044, P < 0.001; χ2 = 4.631, P = 0.031, respectively). The prevalence of thyroid nodules increased along with increasing age (trend χ2 test: χ2 = 515.22 for men, P < 0.001; χ2 = 921.56 for women, P < 0.001). (b) The prevalence of thyroid nodule in the MetS (+) group was higher than in the MetS (−) group for both sexes together (41.71% (1157/2774) versus 33.23% (3572/10748), χ2 = 69.63, P < 0.001) and for men and women separately (female: 48.15% (260/540) versus 35.43% (1437/4056), χ2 = 33.10, P < 0.001; male: 40.15% (897/2234) versus 31.90% (2135/6692), χ2 = 50.80, P < 0.001).
Mentions: The study population characteristics are depicted in Figure 1(a). As noted, the cross-sectional study included a total of 13522 participants (8926 men and 4596 women). The prevalence of TN was 34.97% (33.97% for men and 36.92% for women). The standardized morbidity rate of TN was 33.70% (31.82% for men and 35.35% for women), which was calculated from the population distribution in China in 2009. The prevalence of TN for women was statistically higher than for men in the age ranges 40 to 59 and >70 and was significantly higher in the age range 50 to 59 (49.54% versus 40.04%, χ2 = 29.044, P < 0.001), and so was the prevalence over all ages (χ2 = 11.651, P = 0.001). Furthermore, the prevalence of TN increased along with increased age (trend χ2 test: χ2 = 1200.33 for both sexes, P < 0.001; χ2 = 515.22 for men, P < 0.001; χ2 = 921.56 for women, P < 0.001).

Bottom Line: Individuals with greater WC in 2009 were more likely to suffer from TN in 2012 (RR = 1.434, P = 0.024).Conclusion.Both greater WC and elevated triglycerides are risk factors for new TN in this iodine-adequate area in China.

View Article: PubMed Central - PubMed

Affiliation: Department of International Health Care Center, The Second Affiliated Hospital ZheJiang University College of Medicine, Hangzhou, Zhejiang 310009, China.

ABSTRACT
Objective. The association between thyroid nodule (TN) prevalence and metabolic syndrome (MetS) has only rarely been examined in iodine-adequate areas and needs further clarification. We investigated correlations between MetS and TN prevalence in the iodine-adequate area of Hangzhou, China. Material and Method. A cross-sectional study that screened and recruited individuals for cohort research 3 years later. The 13522 subjects (8926 men, 4596 women) were screened in 2009 for all MetS components, thyroid ultrasound (US), and thyroid function. Cohort research recruited 1610 subjects who were screened in both 2009 and 2012, of whom 1061 underwent follow-up research. Results. The prevalence of TN was higher in the MetS (+) group than in the MetS (-) group (χ (2) = 69.63, P < 0.001) and higher in women than in men (χ (2) = 11.65, P = 0.001). Waist circumference (WC) was positively related to the prevalence of TN (OR = 1.022, P < 0.001). Individuals with greater WC in 2009 were more likely to suffer from TN in 2012 (RR = 1.434, P = 0.024). Elevated triglyceride level was a risk factor for developing new TN (RR = 1.001, P = 0.035). Conclusion. Both greater WC and elevated triglycerides are risk factors for new TN in this iodine-adequate area in China.

No MeSH data available.


Related in: MedlinePlus