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Alepidea amatymbica Eckl. & Zeyh.: A Review of Its Traditional Uses, Phytochemistry, Pharmacology, and Toxicology.

Wintola OA, Afolayan AJ - Evid Based Complement Alternat Med (2014)

Bottom Line: All the phytochemical studies on Alepidea amatymbica obtained from the literature reported the presence of kaurene-type diterpenoids and their derivatives.Pharmacological areas identified on A. amatymbica fresh and dried extract include antibacterial, antifungal, sedative, astringent, antimalarial, anti-inflammatory, antihelminthes, antihypertensive, anti-HIV, and diuretic activities.Literature search on A. amatymbica revealed the use of cell line, brine shrimps, and rats for the determination of the toxicity in the plant.

View Article: PubMed Central - PubMed

Affiliation: Medicinal Plant and Economic Development Research Centre, Department of Botany, University of Fort Hare, Alice 5700, South Africa.

ABSTRACT
Alepidea amatymbica is an important medicinal plant in Southern Africa with a long history of traditional use for the management of conditions like colds, coughs, sore throat, influenza, asthma, and abdominal cramps. Despite the much acclaimed traditional uses of the plant, there is a dearth of scientific information on the review of this plant. Hence, this review is aimed at providing information on the botany, phytochemistry, pharmacology, and toxicology of A. amatymbica. This review uses all the synonyms of the plant obtained from the plant list. Google scholar, Science Direct, PubMed, and Scopus were made use of in addition to the University of Fort Hare's online databases. All the phytochemical studies on Alepidea amatymbica obtained from the literature reported the presence of kaurene-type diterpenoids and their derivatives. Pharmacological areas identified on A. amatymbica fresh and dried extract include antibacterial, antifungal, sedative, astringent, antimalarial, anti-inflammatory, antihelminthes, antihypertensive, anti-HIV, and diuretic activities. Literature search on A. amatymbica revealed the use of cell line, brine shrimps, and rats for the determination of the toxicity in the plant. Clinical trials and product development to fully exploit the medicinal value are also required to validate its folklore use in traditional medicine.

No MeSH data available.


Related in: MedlinePlus

Chemical structures of kaurene-type diterpenoids in Alepidea amatymbica.
© Copyright Policy - open-access
Related In: Results  -  Collection


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fig2: Chemical structures of kaurene-type diterpenoids in Alepidea amatymbica.

Mentions: Some of the phytochemicals isolated and characterized to date from Alepidea amatymbica are showed in Figure 2. These include kaurene-type diterpenoids and their derivatives like ent-9, (11)-dehydro-16-kauren-19-oic acid, ent-16-kauren-19-oic acid, wedelia seco-kaurenolide, and 313-acetoxy which is believed to constitute up to 11.8% of rhizome and root dry mass [20]. The activity of the medicine can most likely be attributed to the diterpenoids it contains, although they have not been tested individually [20]. Several diterpenoid kaurene derivatives have been isolated from the rhizomes and roots of A. amatymbica [30, 31, 38]. Lipophilic extracts of the powdered dried rhizomes of A. amatymbica collected in different localities also confirmed the presence of ent-9, (11)-dehydro-16-kauren-19-oic acid (la), ent-16-kauren-19-oic acid (2a), wedelia seco-kaurenolide (3) and (4), and the 313-acetoxy derivative of 3, previously reported as constituents of the roots and aerial parts of A. amatymbica [30]. The extracts contained additional kaurene derivatives not previously reported. A comparative study of dichloromethane extracts of the roots of several Alepidea species showed the presence of kaurene derivatives in every case. The distribution of all the major compounds found in Alepidea amatymbica is summarized in Table 2. The highly resinous rhizomes contain kaurene-type diterpenoids [30, 31].


Alepidea amatymbica Eckl. & Zeyh.: A Review of Its Traditional Uses, Phytochemistry, Pharmacology, and Toxicology.

Wintola OA, Afolayan AJ - Evid Based Complement Alternat Med (2014)

Chemical structures of kaurene-type diterpenoids in Alepidea amatymbica.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4150506&req=5

fig2: Chemical structures of kaurene-type diterpenoids in Alepidea amatymbica.
Mentions: Some of the phytochemicals isolated and characterized to date from Alepidea amatymbica are showed in Figure 2. These include kaurene-type diterpenoids and their derivatives like ent-9, (11)-dehydro-16-kauren-19-oic acid, ent-16-kauren-19-oic acid, wedelia seco-kaurenolide, and 313-acetoxy which is believed to constitute up to 11.8% of rhizome and root dry mass [20]. The activity of the medicine can most likely be attributed to the diterpenoids it contains, although they have not been tested individually [20]. Several diterpenoid kaurene derivatives have been isolated from the rhizomes and roots of A. amatymbica [30, 31, 38]. Lipophilic extracts of the powdered dried rhizomes of A. amatymbica collected in different localities also confirmed the presence of ent-9, (11)-dehydro-16-kauren-19-oic acid (la), ent-16-kauren-19-oic acid (2a), wedelia seco-kaurenolide (3) and (4), and the 313-acetoxy derivative of 3, previously reported as constituents of the roots and aerial parts of A. amatymbica [30]. The extracts contained additional kaurene derivatives not previously reported. A comparative study of dichloromethane extracts of the roots of several Alepidea species showed the presence of kaurene derivatives in every case. The distribution of all the major compounds found in Alepidea amatymbica is summarized in Table 2. The highly resinous rhizomes contain kaurene-type diterpenoids [30, 31].

Bottom Line: All the phytochemical studies on Alepidea amatymbica obtained from the literature reported the presence of kaurene-type diterpenoids and their derivatives.Pharmacological areas identified on A. amatymbica fresh and dried extract include antibacterial, antifungal, sedative, astringent, antimalarial, anti-inflammatory, antihelminthes, antihypertensive, anti-HIV, and diuretic activities.Literature search on A. amatymbica revealed the use of cell line, brine shrimps, and rats for the determination of the toxicity in the plant.

View Article: PubMed Central - PubMed

Affiliation: Medicinal Plant and Economic Development Research Centre, Department of Botany, University of Fort Hare, Alice 5700, South Africa.

ABSTRACT
Alepidea amatymbica is an important medicinal plant in Southern Africa with a long history of traditional use for the management of conditions like colds, coughs, sore throat, influenza, asthma, and abdominal cramps. Despite the much acclaimed traditional uses of the plant, there is a dearth of scientific information on the review of this plant. Hence, this review is aimed at providing information on the botany, phytochemistry, pharmacology, and toxicology of A. amatymbica. This review uses all the synonyms of the plant obtained from the plant list. Google scholar, Science Direct, PubMed, and Scopus were made use of in addition to the University of Fort Hare's online databases. All the phytochemical studies on Alepidea amatymbica obtained from the literature reported the presence of kaurene-type diterpenoids and their derivatives. Pharmacological areas identified on A. amatymbica fresh and dried extract include antibacterial, antifungal, sedative, astringent, antimalarial, anti-inflammatory, antihelminthes, antihypertensive, anti-HIV, and diuretic activities. Literature search on A. amatymbica revealed the use of cell line, brine shrimps, and rats for the determination of the toxicity in the plant. Clinical trials and product development to fully exploit the medicinal value are also required to validate its folklore use in traditional medicine.

No MeSH data available.


Related in: MedlinePlus