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Serum levels of LL-37 and inflammatory cytokines in plaque and guttate psoriasis.

Hwang YJ, Jung HJ, Kim MJ, Roh NK, Jung JW, Lee YW, Choe YB, Ahn KJ - Mediators Inflamm. (2014)

Bottom Line: Previous investigations of differences in the serum levels of cytokines relative to the clinical psoriatic phenotype have yielded conflicting results.However, the serum levels of inflammatory cytokines (IL-7, IL-22, and IL-23) and LL-37 did not differ significantly between the guttate and plaque phenotypes of psoriasis.The findings of this study suggest that the serum levels of inflammatory cytokines reflect the disease activity rather than determine the morphological phenotype.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Konkuk University School of Medicine, 120-1 Neungdong-ro, Gwangjin-gu, Seoul 143-729, Republic of Korea.

ABSTRACT
Psoriasis is a chronic inflammatory skin disease. It is assumed that the plaque phenotype of psoriasis is associated with T helper (Th) 1 immune response activation, while the guttate phenotype is associated with the Th17 immune response. Previous investigations of differences in the serum levels of cytokines relative to the clinical psoriatic phenotype have yielded conflicting results. This study compared the levels of circulating inflammatory cytokines and LL-37 relative to the morphological phenotype in patients with psoriasis. Seventy-four age-matched patients with psoriasis (32 with guttate psoriasis and 42 with plaque psoriasis) and 12 healthy controls were included. A multiplex cytokine assay and enzyme-linked immunosorbent assay were used to measure levels of Th1- and Th17-derived cytokines and LL-37, respectively. Circulating levels of interferon- (IFN)-γ, interleukin- (IL)-1RA, IL-2, and IL-23, and LL-37 were significantly higher in patients with psoriasis than in healthy controls. However, the serum levels of inflammatory cytokines (IL-7, IL-22, and IL-23) and LL-37 did not differ significantly between the guttate and plaque phenotypes of psoriasis. There was a positive correlation between serum inflammatory cytokine levels and the Psoriasis Area and Severity Index score. The findings of this study suggest that the serum levels of inflammatory cytokines reflect the disease activity rather than determine the morphological phenotype.

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Related in: MedlinePlus

Correlations between serum levels of interleukin- (IL-) 1 receptor antagonist (RA), IL-12 (p40), IL-17A, IL-22, and interferon (IFN)-γ and Psoriasis Area and Severity Index (PASI) scores in patients with psoriasis. The Pearson correlation test and linear regression were used to calculate the linear regression lines.
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Related In: Results  -  Collection


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fig1: Correlations between serum levels of interleukin- (IL-) 1 receptor antagonist (RA), IL-12 (p40), IL-17A, IL-22, and interferon (IFN)-γ and Psoriasis Area and Severity Index (PASI) scores in patients with psoriasis. The Pearson correlation test and linear regression were used to calculate the linear regression lines.

Mentions: The serum levels of 7 inflammatory cytokines and LL-37 in the 74 patients with psoriasis were compared with disease severity (as defined by PASI score) in order to establish the presence of any correlations. IL-12(p40), IL-22, and IFN-γ were significantly and positively correlated with PASI in all patients with psoriasis (Table 4, Figure 1). Although not statistically significant, there was a tendency for both IL-1RA and IL-17A to be positively correlated with PASI (Figure 1).


Serum levels of LL-37 and inflammatory cytokines in plaque and guttate psoriasis.

Hwang YJ, Jung HJ, Kim MJ, Roh NK, Jung JW, Lee YW, Choe YB, Ahn KJ - Mediators Inflamm. (2014)

Correlations between serum levels of interleukin- (IL-) 1 receptor antagonist (RA), IL-12 (p40), IL-17A, IL-22, and interferon (IFN)-γ and Psoriasis Area and Severity Index (PASI) scores in patients with psoriasis. The Pearson correlation test and linear regression were used to calculate the linear regression lines.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4150496&req=5

fig1: Correlations between serum levels of interleukin- (IL-) 1 receptor antagonist (RA), IL-12 (p40), IL-17A, IL-22, and interferon (IFN)-γ and Psoriasis Area and Severity Index (PASI) scores in patients with psoriasis. The Pearson correlation test and linear regression were used to calculate the linear regression lines.
Mentions: The serum levels of 7 inflammatory cytokines and LL-37 in the 74 patients with psoriasis were compared with disease severity (as defined by PASI score) in order to establish the presence of any correlations. IL-12(p40), IL-22, and IFN-γ were significantly and positively correlated with PASI in all patients with psoriasis (Table 4, Figure 1). Although not statistically significant, there was a tendency for both IL-1RA and IL-17A to be positively correlated with PASI (Figure 1).

Bottom Line: Previous investigations of differences in the serum levels of cytokines relative to the clinical psoriatic phenotype have yielded conflicting results.However, the serum levels of inflammatory cytokines (IL-7, IL-22, and IL-23) and LL-37 did not differ significantly between the guttate and plaque phenotypes of psoriasis.The findings of this study suggest that the serum levels of inflammatory cytokines reflect the disease activity rather than determine the morphological phenotype.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Konkuk University School of Medicine, 120-1 Neungdong-ro, Gwangjin-gu, Seoul 143-729, Republic of Korea.

ABSTRACT
Psoriasis is a chronic inflammatory skin disease. It is assumed that the plaque phenotype of psoriasis is associated with T helper (Th) 1 immune response activation, while the guttate phenotype is associated with the Th17 immune response. Previous investigations of differences in the serum levels of cytokines relative to the clinical psoriatic phenotype have yielded conflicting results. This study compared the levels of circulating inflammatory cytokines and LL-37 relative to the morphological phenotype in patients with psoriasis. Seventy-four age-matched patients with psoriasis (32 with guttate psoriasis and 42 with plaque psoriasis) and 12 healthy controls were included. A multiplex cytokine assay and enzyme-linked immunosorbent assay were used to measure levels of Th1- and Th17-derived cytokines and LL-37, respectively. Circulating levels of interferon- (IFN)-γ, interleukin- (IL)-1RA, IL-2, and IL-23, and LL-37 were significantly higher in patients with psoriasis than in healthy controls. However, the serum levels of inflammatory cytokines (IL-7, IL-22, and IL-23) and LL-37 did not differ significantly between the guttate and plaque phenotypes of psoriasis. There was a positive correlation between serum inflammatory cytokine levels and the Psoriasis Area and Severity Index score. The findings of this study suggest that the serum levels of inflammatory cytokines reflect the disease activity rather than determine the morphological phenotype.

Show MeSH
Related in: MedlinePlus