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Low-Salt Intake during Mating or Gestation in Rats Is Associated with Low Birth and Survival Rates of Babies.

Chou R, Hara A, Du D, Shimizu N, Sakuyama H, Uehara Y - J Nutr Metab (2014)

Bottom Line: The pup survival rate was 95% for mothers on a high-salt diet during pregnancy and 64% for mothers on a low-salt diet (P < 0.0001).However, 66% of the neonates survived.A low-salt diet during mating or pregnancy lowers birth rate and the neonates from low-salt mothers during pregnancy were more likely to die than those from high-salt mothers.

View Article: PubMed Central - PubMed

Affiliation: Division of Clinical Nutrition, Faculty of Home Economics, Kyoritsu Women's University, 2-2-1 Hitotsubashi, Chiyoda, Tokyo 101-8437, Japan.

ABSTRACT
We investigated the influence of maternal salt restriction during mating or gestation on birth rate and offspring growth in Dahl salt-sensitive rats (DS). DS were divided into 5 groups: DS fed a low-salt (0.3% NaCl, w/w) (DS-low) or high-salt (4% NaCl, w/w) diet (DS-high) during mating and DS-high or DS-low during gestation, and DS fed regular chow (0.75% NaCl, w/w) (DS-regular) throughout mating and gestation. During the unspecified periods, the rats were given regular chow. DS-low during mating delivered fewer infants than high-salt mothers (P < 0.05). The birth rate on regular chow was 87%. Six out of 11 DS-low rats during pregnancy produced pups while the rats fed a high-salt diet all delivered pups (P < 0.025). The pup survival rate was 67% for high-salt mothers during mating and 54% for mothers on a low-salt diet. The pup survival rate was 95% for mothers on a high-salt diet during pregnancy and 64% for mothers on a low-salt diet (P < 0.0001). Seven out of 8 DS-regular rats during mating delivered 59 neonates. However, 66% of the neonates survived. A low-salt diet during mating or pregnancy lowers birth rate and the neonates from low-salt mothers during pregnancy were more likely to die than those from high-salt mothers.

No MeSH data available.


Cumulative proportion of offspring survival (Kaplan-Meier analysis). Survival prognosis was evaluated from their birth of the rat pups to weaning. Blue circles refer to the death (complete) of pups from high-salt intake mothers; red circles refer to the death (complete) of pups from a low-salt intake mothers. Plus (+), censor. The difference was analyzed by Cox's F-test (T1 = 3.755, T2 = 2.244, F(2, 8) = 6.6930, and P = 0.01958).
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fig2: Cumulative proportion of offspring survival (Kaplan-Meier analysis). Survival prognosis was evaluated from their birth of the rat pups to weaning. Blue circles refer to the death (complete) of pups from high-salt intake mothers; red circles refer to the death (complete) of pups from a low-salt intake mothers. Plus (+), censor. The difference was analyzed by Cox's F-test (T1 = 3.755, T2 = 2.244, F(2, 8) = 6.6930, and P = 0.01958).

Mentions: Using the data from the pups of mothers that were fed the low- and high-salt diets during the pregnancy period, we determined the Kaplan-Meier survival curve in order to increase our understanding of the time course before death (Figure 2). Some of the pups died immediately after birth and a substantial number of pups died during the lactation period.


Low-Salt Intake during Mating or Gestation in Rats Is Associated with Low Birth and Survival Rates of Babies.

Chou R, Hara A, Du D, Shimizu N, Sakuyama H, Uehara Y - J Nutr Metab (2014)

Cumulative proportion of offspring survival (Kaplan-Meier analysis). Survival prognosis was evaluated from their birth of the rat pups to weaning. Blue circles refer to the death (complete) of pups from high-salt intake mothers; red circles refer to the death (complete) of pups from a low-salt intake mothers. Plus (+), censor. The difference was analyzed by Cox's F-test (T1 = 3.755, T2 = 2.244, F(2, 8) = 6.6930, and P = 0.01958).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4150484&req=5

fig2: Cumulative proportion of offspring survival (Kaplan-Meier analysis). Survival prognosis was evaluated from their birth of the rat pups to weaning. Blue circles refer to the death (complete) of pups from high-salt intake mothers; red circles refer to the death (complete) of pups from a low-salt intake mothers. Plus (+), censor. The difference was analyzed by Cox's F-test (T1 = 3.755, T2 = 2.244, F(2, 8) = 6.6930, and P = 0.01958).
Mentions: Using the data from the pups of mothers that were fed the low- and high-salt diets during the pregnancy period, we determined the Kaplan-Meier survival curve in order to increase our understanding of the time course before death (Figure 2). Some of the pups died immediately after birth and a substantial number of pups died during the lactation period.

Bottom Line: The pup survival rate was 95% for mothers on a high-salt diet during pregnancy and 64% for mothers on a low-salt diet (P < 0.0001).However, 66% of the neonates survived.A low-salt diet during mating or pregnancy lowers birth rate and the neonates from low-salt mothers during pregnancy were more likely to die than those from high-salt mothers.

View Article: PubMed Central - PubMed

Affiliation: Division of Clinical Nutrition, Faculty of Home Economics, Kyoritsu Women's University, 2-2-1 Hitotsubashi, Chiyoda, Tokyo 101-8437, Japan.

ABSTRACT
We investigated the influence of maternal salt restriction during mating or gestation on birth rate and offspring growth in Dahl salt-sensitive rats (DS). DS were divided into 5 groups: DS fed a low-salt (0.3% NaCl, w/w) (DS-low) or high-salt (4% NaCl, w/w) diet (DS-high) during mating and DS-high or DS-low during gestation, and DS fed regular chow (0.75% NaCl, w/w) (DS-regular) throughout mating and gestation. During the unspecified periods, the rats were given regular chow. DS-low during mating delivered fewer infants than high-salt mothers (P < 0.05). The birth rate on regular chow was 87%. Six out of 11 DS-low rats during pregnancy produced pups while the rats fed a high-salt diet all delivered pups (P < 0.025). The pup survival rate was 67% for high-salt mothers during mating and 54% for mothers on a low-salt diet. The pup survival rate was 95% for mothers on a high-salt diet during pregnancy and 64% for mothers on a low-salt diet (P < 0.0001). Seven out of 8 DS-regular rats during mating delivered 59 neonates. However, 66% of the neonates survived. A low-salt diet during mating or pregnancy lowers birth rate and the neonates from low-salt mothers during pregnancy were more likely to die than those from high-salt mothers.

No MeSH data available.