Limits...
Low-Salt Intake during Mating or Gestation in Rats Is Associated with Low Birth and Survival Rates of Babies.

Chou R, Hara A, Du D, Shimizu N, Sakuyama H, Uehara Y - J Nutr Metab (2014)

Bottom Line: The pup survival rate was 95% for mothers on a high-salt diet during pregnancy and 64% for mothers on a low-salt diet (P < 0.0001).However, 66% of the neonates survived.A low-salt diet during mating or pregnancy lowers birth rate and the neonates from low-salt mothers during pregnancy were more likely to die than those from high-salt mothers.

View Article: PubMed Central - PubMed

Affiliation: Division of Clinical Nutrition, Faculty of Home Economics, Kyoritsu Women's University, 2-2-1 Hitotsubashi, Chiyoda, Tokyo 101-8437, Japan.

ABSTRACT
We investigated the influence of maternal salt restriction during mating or gestation on birth rate and offspring growth in Dahl salt-sensitive rats (DS). DS were divided into 5 groups: DS fed a low-salt (0.3% NaCl, w/w) (DS-low) or high-salt (4% NaCl, w/w) diet (DS-high) during mating and DS-high or DS-low during gestation, and DS fed regular chow (0.75% NaCl, w/w) (DS-regular) throughout mating and gestation. During the unspecified periods, the rats were given regular chow. DS-low during mating delivered fewer infants than high-salt mothers (P < 0.05). The birth rate on regular chow was 87%. Six out of 11 DS-low rats during pregnancy produced pups while the rats fed a high-salt diet all delivered pups (P < 0.025). The pup survival rate was 67% for high-salt mothers during mating and 54% for mothers on a low-salt diet. The pup survival rate was 95% for mothers on a high-salt diet during pregnancy and 64% for mothers on a low-salt diet (P < 0.0001). Seven out of 8 DS-regular rats during mating delivered 59 neonates. However, 66% of the neonates survived. A low-salt diet during mating or pregnancy lowers birth rate and the neonates from low-salt mothers during pregnancy were more likely to die than those from high-salt mothers.

No MeSH data available.


Protocol of the study. This graph shows each type of salt diet and the time period in which it was fed to the Dahl S rats. 0.3% NaCl, a low-salt (0.3% NaCl, w/w) diet; 0.75% NaCl, regular (0.75% NaCl, w/w) diet; and 4% NaCl, a high-salt (4% NaCl, w/w) diet.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4150484&req=5

fig1: Protocol of the study. This graph shows each type of salt diet and the time period in which it was fed to the Dahl S rats. 0.3% NaCl, a low-salt (0.3% NaCl, w/w) diet; 0.75% NaCl, regular (0.75% NaCl, w/w) diet; and 4% NaCl, a high-salt (4% NaCl, w/w) diet.

Mentions: Dahl S rats were divided into 5 groups (Figure 1): (1) Dahl S rats that were fed a low-salt (0.3% NaCl, w/w) diet (F2Dahl-0.3%, Oriental Yeast Co., Ltd., Tokyo, Japan) for the mating period, (2) Dahl S rats that were fed a high-salt (4% NaCl, w/w) diet (F2Dahl-4%, Oriental Yeast) for the mating period, (3) Dahl S rats that were fed a low-salt (0.3% NaCl diet, w/w) diet for the pregnancy period, (4) Dahl S rats that were fed a high-salt (4% NaCl, w/w) diet (F2Dahl-4%, Oriental Yeast) for the pregnancy period, and (5) Dahl S rats fed regular chow (0.75% NaCl, w/w) throughout the mating and pregnancy periods.


Low-Salt Intake during Mating or Gestation in Rats Is Associated with Low Birth and Survival Rates of Babies.

Chou R, Hara A, Du D, Shimizu N, Sakuyama H, Uehara Y - J Nutr Metab (2014)

Protocol of the study. This graph shows each type of salt diet and the time period in which it was fed to the Dahl S rats. 0.3% NaCl, a low-salt (0.3% NaCl, w/w) diet; 0.75% NaCl, regular (0.75% NaCl, w/w) diet; and 4% NaCl, a high-salt (4% NaCl, w/w) diet.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4150484&req=5

fig1: Protocol of the study. This graph shows each type of salt diet and the time period in which it was fed to the Dahl S rats. 0.3% NaCl, a low-salt (0.3% NaCl, w/w) diet; 0.75% NaCl, regular (0.75% NaCl, w/w) diet; and 4% NaCl, a high-salt (4% NaCl, w/w) diet.
Mentions: Dahl S rats were divided into 5 groups (Figure 1): (1) Dahl S rats that were fed a low-salt (0.3% NaCl, w/w) diet (F2Dahl-0.3%, Oriental Yeast Co., Ltd., Tokyo, Japan) for the mating period, (2) Dahl S rats that were fed a high-salt (4% NaCl, w/w) diet (F2Dahl-4%, Oriental Yeast) for the mating period, (3) Dahl S rats that were fed a low-salt (0.3% NaCl diet, w/w) diet for the pregnancy period, (4) Dahl S rats that were fed a high-salt (4% NaCl, w/w) diet (F2Dahl-4%, Oriental Yeast) for the pregnancy period, and (5) Dahl S rats fed regular chow (0.75% NaCl, w/w) throughout the mating and pregnancy periods.

Bottom Line: The pup survival rate was 95% for mothers on a high-salt diet during pregnancy and 64% for mothers on a low-salt diet (P < 0.0001).However, 66% of the neonates survived.A low-salt diet during mating or pregnancy lowers birth rate and the neonates from low-salt mothers during pregnancy were more likely to die than those from high-salt mothers.

View Article: PubMed Central - PubMed

Affiliation: Division of Clinical Nutrition, Faculty of Home Economics, Kyoritsu Women's University, 2-2-1 Hitotsubashi, Chiyoda, Tokyo 101-8437, Japan.

ABSTRACT
We investigated the influence of maternal salt restriction during mating or gestation on birth rate and offspring growth in Dahl salt-sensitive rats (DS). DS were divided into 5 groups: DS fed a low-salt (0.3% NaCl, w/w) (DS-low) or high-salt (4% NaCl, w/w) diet (DS-high) during mating and DS-high or DS-low during gestation, and DS fed regular chow (0.75% NaCl, w/w) (DS-regular) throughout mating and gestation. During the unspecified periods, the rats were given regular chow. DS-low during mating delivered fewer infants than high-salt mothers (P < 0.05). The birth rate on regular chow was 87%. Six out of 11 DS-low rats during pregnancy produced pups while the rats fed a high-salt diet all delivered pups (P < 0.025). The pup survival rate was 67% for high-salt mothers during mating and 54% for mothers on a low-salt diet. The pup survival rate was 95% for mothers on a high-salt diet during pregnancy and 64% for mothers on a low-salt diet (P < 0.0001). Seven out of 8 DS-regular rats during mating delivered 59 neonates. However, 66% of the neonates survived. A low-salt diet during mating or pregnancy lowers birth rate and the neonates from low-salt mothers during pregnancy were more likely to die than those from high-salt mothers.

No MeSH data available.