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High-throughput sequencing for the study of bacterial pathogen biology.

McAdam PR, Richardson EJ, Fitzgerald JR - Curr. Opin. Microbiol. (2014)

Bottom Line: A revolution in sequencing technologies in recent years has led to dramatically increased throughput and reduced cost of bacterial genome sequencing.For example, the capacity to sequence large numbers of bacterial isolates is enabling high resolution phylogenetic analyses of bacterial populations leading to greatly enhanced understanding of the emergence, adaptation, and transmission of pathogenic clones.In this concise review we provide selected examples of how high throughput sequencing is being applied to understand the biology of bacterial pathogens, and discuss future technological advances likely to have a profound impact on the field.

View Article: PubMed Central - PubMed

Affiliation: The Roslin Institute and Edinburgh Infectious Diseases, University of Edinburgh, Easter Bush Campus, Edinburgh EH25 9RG, United Kingdom.

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Related in: MedlinePlus

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High-throughput sequencing for the study of bacterial pathogen biology.

McAdam PR, Richardson EJ, Fitzgerald JR - Curr. Opin. Microbiol. (2014)

© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4150483&req=5

Bottom Line: A revolution in sequencing technologies in recent years has led to dramatically increased throughput and reduced cost of bacterial genome sequencing.For example, the capacity to sequence large numbers of bacterial isolates is enabling high resolution phylogenetic analyses of bacterial populations leading to greatly enhanced understanding of the emergence, adaptation, and transmission of pathogenic clones.In this concise review we provide selected examples of how high throughput sequencing is being applied to understand the biology of bacterial pathogens, and discuss future technological advances likely to have a profound impact on the field.

View Article: PubMed Central - PubMed

Affiliation: The Roslin Institute and Edinburgh Infectious Diseases, University of Edinburgh, Easter Bush Campus, Edinburgh EH25 9RG, United Kingdom.

Show MeSH
Related in: MedlinePlus