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Ligusticum wallichii Extract Inhibited the Expression of IL-1β after AMI in Rats.

Yuan Z, Zhang J, Yang C - Evid Based Complement Alternat Med (2014)

Bottom Line: This study investigated the effects of Ligusticum wallichii on IL-1β expression in myocardium and central nervous system after AMI.AMI rat was administrated with Ligusticum wallichii extract.Ligusticum wallichii extract reduced the expression of IL-1β in myocardium by regulating TLR4-NF-κB signaling pathway and inhibited IL-1β in hypothalamus by regulating NPY mRNA expression.

View Article: PubMed Central - PubMed

Affiliation: First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 314 An Shan Xi Road, Nan Kai District, Tianjin 300193, China.

ABSTRACT
This study investigated the effects of Ligusticum wallichii on IL-1β expression in myocardium and central nervous system after AMI. AMI rat was administrated with Ligusticum wallichii extract. A series of assays were used to detect the effects of Ligusticum wallichii extract on infarct size, left ventricular ejection fraction, expression of TLR-4, NF-κB, and IL-1β in myocardium, IL-1β expression in serum and hypothalamus, and NPY expression in hypothalamus. We observed that Ligusticum wallichii extract improved the left ventricular ejection fraction and reduced infarct area enlargement after AMI, by inhibiting the expression of IL-1β in myocardium, serum, and hypothalamus. Ligusticum wallichii extract reduced the expression of IL-1β in myocardium by regulating TLR4-NF-κB signaling pathway and inhibited IL-1β in hypothalamus by regulating NPY mRNA expression.

No MeSH data available.


Related in: MedlinePlus

Effect of Ligusticum wallichii on the NPY mRNA expression in the hypothalamus of AMI rats. Quantitative RT-PCR was performed. The NPY mRNA expression was significantly upregulated 1w after AMI versus sham group (**P < 0.01). Ligusticum wallichii and aspirin inhibited the hypothalamus NPY mRNA expression versus AMI group (*P < 0.05), but there were no remarkable differences between LW group and aspirin group.
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fig5: Effect of Ligusticum wallichii on the NPY mRNA expression in the hypothalamus of AMI rats. Quantitative RT-PCR was performed. The NPY mRNA expression was significantly upregulated 1w after AMI versus sham group (**P < 0.01). Ligusticum wallichii and aspirin inhibited the hypothalamus NPY mRNA expression versus AMI group (*P < 0.05), but there were no remarkable differences between LW group and aspirin group.

Mentions: The hypothalamus NPY mRNA expression was assessed by quantitative reverse transcription-PCR (Figure 5). The hypothalamus NPY mRNA expression was elevated 1W after AMI. LW and aspirin inhibited NPY mRNA expression in hypothalamus, but there were no remarkable differences between LW group and aspirin group.


Ligusticum wallichii Extract Inhibited the Expression of IL-1β after AMI in Rats.

Yuan Z, Zhang J, Yang C - Evid Based Complement Alternat Med (2014)

Effect of Ligusticum wallichii on the NPY mRNA expression in the hypothalamus of AMI rats. Quantitative RT-PCR was performed. The NPY mRNA expression was significantly upregulated 1w after AMI versus sham group (**P < 0.01). Ligusticum wallichii and aspirin inhibited the hypothalamus NPY mRNA expression versus AMI group (*P < 0.05), but there were no remarkable differences between LW group and aspirin group.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4150451&req=5

fig5: Effect of Ligusticum wallichii on the NPY mRNA expression in the hypothalamus of AMI rats. Quantitative RT-PCR was performed. The NPY mRNA expression was significantly upregulated 1w after AMI versus sham group (**P < 0.01). Ligusticum wallichii and aspirin inhibited the hypothalamus NPY mRNA expression versus AMI group (*P < 0.05), but there were no remarkable differences between LW group and aspirin group.
Mentions: The hypothalamus NPY mRNA expression was assessed by quantitative reverse transcription-PCR (Figure 5). The hypothalamus NPY mRNA expression was elevated 1W after AMI. LW and aspirin inhibited NPY mRNA expression in hypothalamus, but there were no remarkable differences between LW group and aspirin group.

Bottom Line: This study investigated the effects of Ligusticum wallichii on IL-1β expression in myocardium and central nervous system after AMI.AMI rat was administrated with Ligusticum wallichii extract.Ligusticum wallichii extract reduced the expression of IL-1β in myocardium by regulating TLR4-NF-κB signaling pathway and inhibited IL-1β in hypothalamus by regulating NPY mRNA expression.

View Article: PubMed Central - PubMed

Affiliation: First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 314 An Shan Xi Road, Nan Kai District, Tianjin 300193, China.

ABSTRACT
This study investigated the effects of Ligusticum wallichii on IL-1β expression in myocardium and central nervous system after AMI. AMI rat was administrated with Ligusticum wallichii extract. A series of assays were used to detect the effects of Ligusticum wallichii extract on infarct size, left ventricular ejection fraction, expression of TLR-4, NF-κB, and IL-1β in myocardium, IL-1β expression in serum and hypothalamus, and NPY expression in hypothalamus. We observed that Ligusticum wallichii extract improved the left ventricular ejection fraction and reduced infarct area enlargement after AMI, by inhibiting the expression of IL-1β in myocardium, serum, and hypothalamus. Ligusticum wallichii extract reduced the expression of IL-1β in myocardium by regulating TLR4-NF-κB signaling pathway and inhibited IL-1β in hypothalamus by regulating NPY mRNA expression.

No MeSH data available.


Related in: MedlinePlus