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Ligusticum wallichii Extract Inhibited the Expression of IL-1β after AMI in Rats.

Yuan Z, Zhang J, Yang C - Evid Based Complement Alternat Med (2014)

Bottom Line: This study investigated the effects of Ligusticum wallichii on IL-1β expression in myocardium and central nervous system after AMI.AMI rat was administrated with Ligusticum wallichii extract.Ligusticum wallichii extract reduced the expression of IL-1β in myocardium by regulating TLR4-NF-κB signaling pathway and inhibited IL-1β in hypothalamus by regulating NPY mRNA expression.

View Article: PubMed Central - PubMed

Affiliation: First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 314 An Shan Xi Road, Nan Kai District, Tianjin 300193, China.

ABSTRACT
This study investigated the effects of Ligusticum wallichii on IL-1β expression in myocardium and central nervous system after AMI. AMI rat was administrated with Ligusticum wallichii extract. A series of assays were used to detect the effects of Ligusticum wallichii extract on infarct size, left ventricular ejection fraction, expression of TLR-4, NF-κB, and IL-1β in myocardium, IL-1β expression in serum and hypothalamus, and NPY expression in hypothalamus. We observed that Ligusticum wallichii extract improved the left ventricular ejection fraction and reduced infarct area enlargement after AMI, by inhibiting the expression of IL-1β in myocardium, serum, and hypothalamus. Ligusticum wallichii extract reduced the expression of IL-1β in myocardium by regulating TLR4-NF-κB signaling pathway and inhibited IL-1β in hypothalamus by regulating NPY mRNA expression.

No MeSH data available.


Related in: MedlinePlus

Representative images for infarcted hearts at one week time point after AMI. (a) NBT staining of infarcted area. The color of myocardium in the control group was dark blue, but the infarct area was hoar. (b) Ligusticum wallichii (10 mg/Kg/d body weight) and aspirin (10 mg/Kg/d body weight) reduced the MIS versus AMI group (*P < 0.05). But there were no remarkable differences between LW group and aspirin group.
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fig2: Representative images for infarcted hearts at one week time point after AMI. (a) NBT staining of infarcted area. The color of myocardium in the control group was dark blue, but the infarct area was hoar. (b) Ligusticum wallichii (10 mg/Kg/d body weight) and aspirin (10 mg/Kg/d body weight) reduced the MIS versus AMI group (*P < 0.05). But there were no remarkable differences between LW group and aspirin group.

Mentions: The infarct area was assessed by NBT staining (Figure 2). NBT stain showed that the color of myocardium in the control group was dark blue, but the infarct area of AMI model group was hoar. One week after infarction, a large infarcted area with a collapsed and pale left ventricular wall was seen under the ligated silk. Compared to the sham group, larger infarcted area was detected accompanying global enlargement of the heart in the AMI group. Ligusticum wallichii and aspirin treatment reduced infarct area enlargement.


Ligusticum wallichii Extract Inhibited the Expression of IL-1β after AMI in Rats.

Yuan Z, Zhang J, Yang C - Evid Based Complement Alternat Med (2014)

Representative images for infarcted hearts at one week time point after AMI. (a) NBT staining of infarcted area. The color of myocardium in the control group was dark blue, but the infarct area was hoar. (b) Ligusticum wallichii (10 mg/Kg/d body weight) and aspirin (10 mg/Kg/d body weight) reduced the MIS versus AMI group (*P < 0.05). But there were no remarkable differences between LW group and aspirin group.
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4150451&req=5

fig2: Representative images for infarcted hearts at one week time point after AMI. (a) NBT staining of infarcted area. The color of myocardium in the control group was dark blue, but the infarct area was hoar. (b) Ligusticum wallichii (10 mg/Kg/d body weight) and aspirin (10 mg/Kg/d body weight) reduced the MIS versus AMI group (*P < 0.05). But there were no remarkable differences between LW group and aspirin group.
Mentions: The infarct area was assessed by NBT staining (Figure 2). NBT stain showed that the color of myocardium in the control group was dark blue, but the infarct area of AMI model group was hoar. One week after infarction, a large infarcted area with a collapsed and pale left ventricular wall was seen under the ligated silk. Compared to the sham group, larger infarcted area was detected accompanying global enlargement of the heart in the AMI group. Ligusticum wallichii and aspirin treatment reduced infarct area enlargement.

Bottom Line: This study investigated the effects of Ligusticum wallichii on IL-1β expression in myocardium and central nervous system after AMI.AMI rat was administrated with Ligusticum wallichii extract.Ligusticum wallichii extract reduced the expression of IL-1β in myocardium by regulating TLR4-NF-κB signaling pathway and inhibited IL-1β in hypothalamus by regulating NPY mRNA expression.

View Article: PubMed Central - PubMed

Affiliation: First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 314 An Shan Xi Road, Nan Kai District, Tianjin 300193, China.

ABSTRACT
This study investigated the effects of Ligusticum wallichii on IL-1β expression in myocardium and central nervous system after AMI. AMI rat was administrated with Ligusticum wallichii extract. A series of assays were used to detect the effects of Ligusticum wallichii extract on infarct size, left ventricular ejection fraction, expression of TLR-4, NF-κB, and IL-1β in myocardium, IL-1β expression in serum and hypothalamus, and NPY expression in hypothalamus. We observed that Ligusticum wallichii extract improved the left ventricular ejection fraction and reduced infarct area enlargement after AMI, by inhibiting the expression of IL-1β in myocardium, serum, and hypothalamus. Ligusticum wallichii extract reduced the expression of IL-1β in myocardium by regulating TLR4-NF-κB signaling pathway and inhibited IL-1β in hypothalamus by regulating NPY mRNA expression.

No MeSH data available.


Related in: MedlinePlus