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CNS Involvement in AML Patient Treated with 5-Azacytidine.

Vasilatou D, Papageorgiou S, Bazani E, Prasouli A, Economopoulou C, Roumpakis C, Karakitsos P, Dimitriadis G, Pappa V - Case Rep Hematol (2014)

Bottom Line: Central nervous system (CNS) involvement in acute myeloid leukemia (AML) is a rare complication of the disease and is associated with poor prognosis.Sometimes the clinical presentation can be unspecific and the diagnosis can be very challenging.Here we report a case of CNS infiltration in a patient suffering from AML who presented with normal complete blood count and altered mental status.

View Article: PubMed Central - PubMed

Affiliation: Second Department of Internal Medicine and Research Institute, Athens University Medical School, Attikon University General Hospital, 1 Rimini Street, 12462 Athens, Greece.

ABSTRACT
Central nervous system (CNS) involvement in acute myeloid leukemia (AML) is a rare complication of the disease and is associated with poor prognosis. Sometimes the clinical presentation can be unspecific and the diagnosis can be very challenging. Here we report a case of CNS infiltration in a patient suffering from AML who presented with normal complete blood count and altered mental status.

No MeSH data available.


Related in: MedlinePlus

The MRI of the brain showed enhancement of the left trigeminal (a) and both oculomotor (b) and vestibulocochlear nerves (c) and signs of leptomeningeal disease.
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fig1: The MRI of the brain showed enhancement of the left trigeminal (a) and both oculomotor (b) and vestibulocochlear nerves (c) and signs of leptomeningeal disease.

Mentions: The brain CT scan revealed two lesions 1.2 and 1.1 cm on the meninges of the frontal and occipital lobe of right hemisphere and no sign of brain edema. The patient underwent an MRI of the brain that showed enhancement of both trigeminal (especially the left) and both oculomotor and vestibulocochlear nerves and abnormal meningeal enhancement in flair sequence (Figures 1(a)–1(c)). A lumbar puncture was performed and the cerebrospinal fluid (CSF) analysis revealed 390 cells/mm3 (20% neutrophils and 80% lymphocytes) and 20 red blood cells (RBC)/mm3. The gram strain was negative and so was the Cryptococcus neoformans antigen tested by the Indian ink method. In addition, CSF glucose was 62 mg/dL (with blood glucose: 115 mg/dL), LDH was 277 U/L, total proteins were 325.3 mg/dL (normal values 15–45 mg/dL) and albumin was 268.3 mg/dL.


CNS Involvement in AML Patient Treated with 5-Azacytidine.

Vasilatou D, Papageorgiou S, Bazani E, Prasouli A, Economopoulou C, Roumpakis C, Karakitsos P, Dimitriadis G, Pappa V - Case Rep Hematol (2014)

The MRI of the brain showed enhancement of the left trigeminal (a) and both oculomotor (b) and vestibulocochlear nerves (c) and signs of leptomeningeal disease.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150438&req=5

fig1: The MRI of the brain showed enhancement of the left trigeminal (a) and both oculomotor (b) and vestibulocochlear nerves (c) and signs of leptomeningeal disease.
Mentions: The brain CT scan revealed two lesions 1.2 and 1.1 cm on the meninges of the frontal and occipital lobe of right hemisphere and no sign of brain edema. The patient underwent an MRI of the brain that showed enhancement of both trigeminal (especially the left) and both oculomotor and vestibulocochlear nerves and abnormal meningeal enhancement in flair sequence (Figures 1(a)–1(c)). A lumbar puncture was performed and the cerebrospinal fluid (CSF) analysis revealed 390 cells/mm3 (20% neutrophils and 80% lymphocytes) and 20 red blood cells (RBC)/mm3. The gram strain was negative and so was the Cryptococcus neoformans antigen tested by the Indian ink method. In addition, CSF glucose was 62 mg/dL (with blood glucose: 115 mg/dL), LDH was 277 U/L, total proteins were 325.3 mg/dL (normal values 15–45 mg/dL) and albumin was 268.3 mg/dL.

Bottom Line: Central nervous system (CNS) involvement in acute myeloid leukemia (AML) is a rare complication of the disease and is associated with poor prognosis.Sometimes the clinical presentation can be unspecific and the diagnosis can be very challenging.Here we report a case of CNS infiltration in a patient suffering from AML who presented with normal complete blood count and altered mental status.

View Article: PubMed Central - PubMed

Affiliation: Second Department of Internal Medicine and Research Institute, Athens University Medical School, Attikon University General Hospital, 1 Rimini Street, 12462 Athens, Greece.

ABSTRACT
Central nervous system (CNS) involvement in acute myeloid leukemia (AML) is a rare complication of the disease and is associated with poor prognosis. Sometimes the clinical presentation can be unspecific and the diagnosis can be very challenging. Here we report a case of CNS infiltration in a patient suffering from AML who presented with normal complete blood count and altered mental status.

No MeSH data available.


Related in: MedlinePlus