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Anticancer, anti-inflammatory, and analgesic activities of synthesized 2-(substituted phenoxy) acetamide derivatives.

Rani P, Pal D, Hegde RR, Hashim SR - Biomed Res Int (2014)

Bottom Line: These investigations revealed that synthesized products 3a-j with halogens on the aromatic ring favors as the anticancer and anti-inflammatory activity.Among all, compound 3c N-(1-(4-chlorophenyl)ethyl)-2-(4-nitrophenoxy)acetamide exhibited anticancer, anti-inflammatory, and analgesic activities.In conclusion, 3c may have potential to be developed into a therapeutic agent.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, School of Sciences, IFTM University, Moradabad, Uttar Pradesh, India.

ABSTRACT
The aphorism was to develop new chemical entities as potential anticancer, anti-inflammatory, and analgesic agents. The Leuckart synthetic pathway was utilized in development of novel series of 2-(substituted phenoxy)-N-(1-phenylethyl)acetamide derivatives. The compounds containing 1-phenylethylamine as basic moiety attached to substituted phenols were assessed for their anticancer activity against MCF-7 (breast cancer), SK-N-SH (neuroblastoma), anti-inflammatory activity, and analgesic activity. These investigations revealed that synthesized products 3a-j with halogens on the aromatic ring favors as the anticancer and anti-inflammatory activity. Among all, compound 3c N-(1-(4-chlorophenyl)ethyl)-2-(4-nitrophenoxy)acetamide exhibited anticancer, anti-inflammatory, and analgesic activities. In conclusion, 3c may have potential to be developed into a therapeutic agent.

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Graphical representation of (% inhibition) of anti-inflammatory activity.
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fig4: Graphical representation of (% inhibition) of anti-inflammatory activity.

Mentions: All compounds 3a–j were subjected for preliminary toxicity test as per organization for Economic Co-operation and Development (OECD) guidelines in rats and 100 mg/kg was used as therapeutic dose. Acute anti-inflammatory activity was performed by carrageenan induced rat paw edema method by Newbould [26]. Diclofenac sodium was used as a reference standard. Compounds 3b, 3c, and 3g exhibited potent anti-inflammatory activity similar to the standard (Table 3, Figure 4). The analgesic effects of compounds 3b, 3c, 3e, 3g, and 3h were found to be nearly of standard (Table 4, Figure 5).


Anticancer, anti-inflammatory, and analgesic activities of synthesized 2-(substituted phenoxy) acetamide derivatives.

Rani P, Pal D, Hegde RR, Hashim SR - Biomed Res Int (2014)

Graphical representation of (% inhibition) of anti-inflammatory activity.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150437&req=5

fig4: Graphical representation of (% inhibition) of anti-inflammatory activity.
Mentions: All compounds 3a–j were subjected for preliminary toxicity test as per organization for Economic Co-operation and Development (OECD) guidelines in rats and 100 mg/kg was used as therapeutic dose. Acute anti-inflammatory activity was performed by carrageenan induced rat paw edema method by Newbould [26]. Diclofenac sodium was used as a reference standard. Compounds 3b, 3c, and 3g exhibited potent anti-inflammatory activity similar to the standard (Table 3, Figure 4). The analgesic effects of compounds 3b, 3c, 3e, 3g, and 3h were found to be nearly of standard (Table 4, Figure 5).

Bottom Line: These investigations revealed that synthesized products 3a-j with halogens on the aromatic ring favors as the anticancer and anti-inflammatory activity.Among all, compound 3c N-(1-(4-chlorophenyl)ethyl)-2-(4-nitrophenoxy)acetamide exhibited anticancer, anti-inflammatory, and analgesic activities.In conclusion, 3c may have potential to be developed into a therapeutic agent.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, School of Sciences, IFTM University, Moradabad, Uttar Pradesh, India.

ABSTRACT
The aphorism was to develop new chemical entities as potential anticancer, anti-inflammatory, and analgesic agents. The Leuckart synthetic pathway was utilized in development of novel series of 2-(substituted phenoxy)-N-(1-phenylethyl)acetamide derivatives. The compounds containing 1-phenylethylamine as basic moiety attached to substituted phenols were assessed for their anticancer activity against MCF-7 (breast cancer), SK-N-SH (neuroblastoma), anti-inflammatory activity, and analgesic activity. These investigations revealed that synthesized products 3a-j with halogens on the aromatic ring favors as the anticancer and anti-inflammatory activity. Among all, compound 3c N-(1-(4-chlorophenyl)ethyl)-2-(4-nitrophenoxy)acetamide exhibited anticancer, anti-inflammatory, and analgesic activities. In conclusion, 3c may have potential to be developed into a therapeutic agent.

Show MeSH
Related in: MedlinePlus