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Corneal collagen cross-linking with hypoosmolar riboflavin solution in keratoconic corneas.

Gu S, Fan Z, Wang L, Tao X, Zhang Y, Mu G - Biomed Res Int (2014)

Bottom Line: After CXL, the thickness decreased to 410.3 ± 14.5 μm at the last follow-up.The mean CDVA was 0.54 ± 0.23 logarithm of the minimal angle of resolution before treatment and increased to 0.51 ± 0.21 logarithm at the last follow-up.The ECD was 2731.4 ± 191.8 cells/mm(2) before treatment and was 2733.4 ± 222.6 cells/mm(2) at 12 months after treatment.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Shandong Provincial Hospital, Shandong University, No. 324, Jing 5 Road, Huaiyin District, Jinan, Shandong 250021, China.

ABSTRACT

Purpose: To report the 12-month outcomes of corneal collagen cross-linking (CXL) with a hypoosmolar riboflavin and ultraviolet-A (UVA) irradiation in thin corneas.

Methods: Eight eyes underwent CXL using a hypoosmolar riboflavin solution after epithelial removal. The corrected distance visual acuity (CDVA), manifest refraction, the mean thinnest corneal thickness (MTCT), and the endothelial cell density (ECD) were evaluated before and 6 and 12 months after CXL.

Results: The MTCT was 413.9 ± 12.4 μm before treatment and reduced to 381.1 ± 7.3 μm after the removal of the epithelium. After CXL, the thickness decreased to 410.3 ± 14.5 μm at the last follow-up. Before treatment, the mean K-value of the apex of the keratoconus corneas was 58.7 ± 3.5 diopters and slightly decreased (57.7 ± 4.9 diopters) at 12 months. The mean CDVA was 0.54 ± 0.23 logarithm of the minimal angle of resolution before treatment and increased to 0.51 ± 0.21 logarithm at the last follow-up. The ECD was 2731.4 ± 191.8 cells/mm(2) before treatment and was 2733.4 ± 222.6 cells/mm(2) at 12 months after treatment.

Conclusions: CXL with a hypoosmolar riboflavin in thin corneas seems to be a promising method for keratoconic eyes with the mean thinnest corneal thickness less than 400 μm without epithelium.

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Bar graph showing the mean thinnest corneal thickness (MTCT) of patients with/without epithelium, after swelling by the hypoosmolar riboflavin solution and 6 months and 12 months after CXL.
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fig1: Bar graph showing the mean thinnest corneal thickness (MTCT) of patients with/without epithelium, after swelling by the hypoosmolar riboflavin solution and 6 months and 12 months after CXL.

Mentions: Before treatment, the MTCT was 413.9 ± 12.4 μm and 381.1 ± 7.3 μm with and without epithelium. After swelling by the hypoosmolar riboflavin solution, the cornea thickness increased to 443.8 ± 23.9 μm. The MTCT decreased at 6 months (411.5 ± 15.2 μm) and remained stable at 12 months (410.3 ± 14.5 μm) after treatment (Figure 1). Before and after operation the MTCT differences were not significant at 6 months (P = 0.4) and 12 months (P = 0.233).


Corneal collagen cross-linking with hypoosmolar riboflavin solution in keratoconic corneas.

Gu S, Fan Z, Wang L, Tao X, Zhang Y, Mu G - Biomed Res Int (2014)

Bar graph showing the mean thinnest corneal thickness (MTCT) of patients with/without epithelium, after swelling by the hypoosmolar riboflavin solution and 6 months and 12 months after CXL.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150415&req=5

fig1: Bar graph showing the mean thinnest corneal thickness (MTCT) of patients with/without epithelium, after swelling by the hypoosmolar riboflavin solution and 6 months and 12 months after CXL.
Mentions: Before treatment, the MTCT was 413.9 ± 12.4 μm and 381.1 ± 7.3 μm with and without epithelium. After swelling by the hypoosmolar riboflavin solution, the cornea thickness increased to 443.8 ± 23.9 μm. The MTCT decreased at 6 months (411.5 ± 15.2 μm) and remained stable at 12 months (410.3 ± 14.5 μm) after treatment (Figure 1). Before and after operation the MTCT differences were not significant at 6 months (P = 0.4) and 12 months (P = 0.233).

Bottom Line: After CXL, the thickness decreased to 410.3 ± 14.5 μm at the last follow-up.The mean CDVA was 0.54 ± 0.23 logarithm of the minimal angle of resolution before treatment and increased to 0.51 ± 0.21 logarithm at the last follow-up.The ECD was 2731.4 ± 191.8 cells/mm(2) before treatment and was 2733.4 ± 222.6 cells/mm(2) at 12 months after treatment.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Shandong Provincial Hospital, Shandong University, No. 324, Jing 5 Road, Huaiyin District, Jinan, Shandong 250021, China.

ABSTRACT

Purpose: To report the 12-month outcomes of corneal collagen cross-linking (CXL) with a hypoosmolar riboflavin and ultraviolet-A (UVA) irradiation in thin corneas.

Methods: Eight eyes underwent CXL using a hypoosmolar riboflavin solution after epithelial removal. The corrected distance visual acuity (CDVA), manifest refraction, the mean thinnest corneal thickness (MTCT), and the endothelial cell density (ECD) were evaluated before and 6 and 12 months after CXL.

Results: The MTCT was 413.9 ± 12.4 μm before treatment and reduced to 381.1 ± 7.3 μm after the removal of the epithelium. After CXL, the thickness decreased to 410.3 ± 14.5 μm at the last follow-up. Before treatment, the mean K-value of the apex of the keratoconus corneas was 58.7 ± 3.5 diopters and slightly decreased (57.7 ± 4.9 diopters) at 12 months. The mean CDVA was 0.54 ± 0.23 logarithm of the minimal angle of resolution before treatment and increased to 0.51 ± 0.21 logarithm at the last follow-up. The ECD was 2731.4 ± 191.8 cells/mm(2) before treatment and was 2733.4 ± 222.6 cells/mm(2) at 12 months after treatment.

Conclusions: CXL with a hypoosmolar riboflavin in thin corneas seems to be a promising method for keratoconic eyes with the mean thinnest corneal thickness less than 400 μm without epithelium.

Show MeSH
Related in: MedlinePlus