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Protonation equilibria of biologically active ligands in mixed aqueous organic solvents.

El-Sherif AA, Shoukry MM, Abd Elkarim AT, Barakat MH - Bioinorg Chem Appl (2014)

Bottom Line: The review is mainly concerned with the protonation equilibria of biologically active ligands like amino acids, peptides, DNA constituents, and amino acid esters in nonaqueous media.Equilibrium concentrations of proton-ligand formation as a function of pH were investigated.Also, thermodynamics associated with protonation equilibria were also discussed.

View Article: PubMed Central - PubMed

Affiliation: Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt ; Department of Chemistry, Faculty of Arts and Science, Northern Border University, Rafha, Saudi Arabia.

ABSTRACT
The review is mainly concerned with the protonation equilibria of biologically active ligands like amino acids, peptides, DNA constituents, and amino acid esters in nonaqueous media. Equilibrium concentrations of proton-ligand formation as a function of pH were investigated. Also, thermodynamics associated with protonation equilibria were also discussed.

No MeSH data available.


Van't Hoff plot of log⁡⁡K of glycine in 50% DMSO-50% H2O mixture (log⁡⁡K1 denotes protonation of amino group and log⁡⁡K2 denotes protonation of carboxylate group).
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fig14: Van't Hoff plot of log⁡⁡K of glycine in 50% DMSO-50% H2O mixture (log⁡⁡K1 denotes protonation of amino group and log⁡⁡K2 denotes protonation of carboxylate group).

Mentions: The protonation reactions (L− + H+⇌LH±, corresponding to –NH2 group) and (LH± + H+⇌LH2+, corresponding to carboxylate group) in Table 12 of the investigated amino acids are exothermic (Figure 14). Three factors affect these protonation reactions:


Protonation equilibria of biologically active ligands in mixed aqueous organic solvents.

El-Sherif AA, Shoukry MM, Abd Elkarim AT, Barakat MH - Bioinorg Chem Appl (2014)

Van't Hoff plot of log⁡⁡K of glycine in 50% DMSO-50% H2O mixture (log⁡⁡K1 denotes protonation of amino group and log⁡⁡K2 denotes protonation of carboxylate group).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150405&req=5

fig14: Van't Hoff plot of log⁡⁡K of glycine in 50% DMSO-50% H2O mixture (log⁡⁡K1 denotes protonation of amino group and log⁡⁡K2 denotes protonation of carboxylate group).
Mentions: The protonation reactions (L− + H+⇌LH±, corresponding to –NH2 group) and (LH± + H+⇌LH2+, corresponding to carboxylate group) in Table 12 of the investigated amino acids are exothermic (Figure 14). Three factors affect these protonation reactions:

Bottom Line: The review is mainly concerned with the protonation equilibria of biologically active ligands like amino acids, peptides, DNA constituents, and amino acid esters in nonaqueous media.Equilibrium concentrations of proton-ligand formation as a function of pH were investigated.Also, thermodynamics associated with protonation equilibria were also discussed.

View Article: PubMed Central - PubMed

Affiliation: Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt ; Department of Chemistry, Faculty of Arts and Science, Northern Border University, Rafha, Saudi Arabia.

ABSTRACT
The review is mainly concerned with the protonation equilibria of biologically active ligands like amino acids, peptides, DNA constituents, and amino acid esters in nonaqueous media. Equilibrium concentrations of proton-ligand formation as a function of pH were investigated. Also, thermodynamics associated with protonation equilibria were also discussed.

No MeSH data available.