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Protonation equilibria of biologically active ligands in mixed aqueous organic solvents.

El-Sherif AA, Shoukry MM, Abd Elkarim AT, Barakat MH - Bioinorg Chem Appl (2014)

Bottom Line: The review is mainly concerned with the protonation equilibria of biologically active ligands like amino acids, peptides, DNA constituents, and amino acid esters in nonaqueous media.Equilibrium concentrations of proton-ligand formation as a function of pH were investigated.Also, thermodynamics associated with protonation equilibria were also discussed.

View Article: PubMed Central - PubMed

Affiliation: Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt ; Department of Chemistry, Faculty of Arts and Science, Northern Border University, Rafha, Saudi Arabia.

ABSTRACT
The review is mainly concerned with the protonation equilibria of biologically active ligands like amino acids, peptides, DNA constituents, and amino acid esters in nonaqueous media. Equilibrium concentrations of proton-ligand formation as a function of pH were investigated. Also, thermodynamics associated with protonation equilibria were also discussed.

No MeSH data available.


Species distribution diagram (25°C, I = 0.1 M NaCl) for Gly-Gly system as a function of pH in 20% ethanol-80% water (L = 1.5 × 10−3 M).
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fig6: Species distribution diagram (25°C, I = 0.1 M NaCl) for Gly-Gly system as a function of pH in 20% ethanol-80% water (L = 1.5 × 10−3 M).

Mentions: Estimation of equilibrium concentrations of proton-ligand formation as a function of pH provides a useful picture of proton-ligand binding in media [16]. Figures 5, 6, 7, and 8 show the change of different species of dipeptides with pH. It is seen from these figures that the most predominant species is HL (total concentration of the zwitterion and the neutral form) between pH 5 and 7 in all ethanol-water media.


Protonation equilibria of biologically active ligands in mixed aqueous organic solvents.

El-Sherif AA, Shoukry MM, Abd Elkarim AT, Barakat MH - Bioinorg Chem Appl (2014)

Species distribution diagram (25°C, I = 0.1 M NaCl) for Gly-Gly system as a function of pH in 20% ethanol-80% water (L = 1.5 × 10−3 M).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150405&req=5

fig6: Species distribution diagram (25°C, I = 0.1 M NaCl) for Gly-Gly system as a function of pH in 20% ethanol-80% water (L = 1.5 × 10−3 M).
Mentions: Estimation of equilibrium concentrations of proton-ligand formation as a function of pH provides a useful picture of proton-ligand binding in media [16]. Figures 5, 6, 7, and 8 show the change of different species of dipeptides with pH. It is seen from these figures that the most predominant species is HL (total concentration of the zwitterion and the neutral form) between pH 5 and 7 in all ethanol-water media.

Bottom Line: The review is mainly concerned with the protonation equilibria of biologically active ligands like amino acids, peptides, DNA constituents, and amino acid esters in nonaqueous media.Equilibrium concentrations of proton-ligand formation as a function of pH were investigated.Also, thermodynamics associated with protonation equilibria were also discussed.

View Article: PubMed Central - PubMed

Affiliation: Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt ; Department of Chemistry, Faculty of Arts and Science, Northern Border University, Rafha, Saudi Arabia.

ABSTRACT
The review is mainly concerned with the protonation equilibria of biologically active ligands like amino acids, peptides, DNA constituents, and amino acid esters in nonaqueous media. Equilibrium concentrations of proton-ligand formation as a function of pH were investigated. Also, thermodynamics associated with protonation equilibria were also discussed.

No MeSH data available.