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Assessment of serum zinc levels of patients with thalassemia compared to their siblings.

El Missiry M, Hamed Hussein M, Khalid S, Yaqub N, Khan S, Itrat F, Uderzo C, Faulkner L - Anemia (2014)

Bottom Line: Serum Zn levels and anthropometric data measures were compared among siblings.There was no significant difference between the two groups.Patients' serum Zn values correlated with their siblings' values.

View Article: PubMed Central - PubMed

Affiliation: Cure2Children Foundation, Via Marconi 30, 50131 Florence, Italy.

ABSTRACT
Zinc (Zn) is essential for appropriate growth and proper immune function, both of which may be impaired in thalassemia children. Factors that can affect serum Zn levels in these patients may be related to their disease or treatment or nutritional causes. We assessed the serum Zn levels of children with thalassemia paired with a sibling. Zn levels were obtained from 30 children in Islamabad, Pakistan. Serum Zn levels and anthropometric data measures were compared among siblings. Thalassemia patients' median age was 4.5 years (range 1-10.6 years) and siblings was 7.8 years (range 1.1-17 years). The median serum Zn levels for both groups were within normal range: 100 μg/dL (10 μg/dL-297 μg/dL) for patients and 92 μg/dL (13 μg/dL-212 μg/dL) for siblings. There was no significant difference between the two groups. Patients' serum Zn values correlated positively with their corresponding siblings (r = 0.635, P < 0.001). There were no correlations between patients' Zn levels, height for age Z-scores, serum ferritin levels, chelation, or blood counts (including both total leukocyte and absolute lymphocyte counts). Patients' serum Zn values correlated with their siblings' values. In this study, patients with thalassemia do not seem to have disease-related Zn deficiency.

No MeSH data available.


Related in: MedlinePlus

Correlation between patients' serum Zn values. Levels correlated positively with corresponding (r = 0.635, P < 0.001).
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fig2: Correlation between patients' serum Zn values. Levels correlated positively with corresponding (r = 0.635, P < 0.001).

Mentions: Median patient age was 4.5 years (ranging from 1 to 10.6 years) and median sibling age was 7.3 years (ranging from 1.1 to 17 years). Patients' serum Zn ranged from 10 μg/dL to 297 μg/dL (median 100 μg/dL), while siblings' serum Zn ranged from 13 μg/dL to 212 μg/dL (median 92 μg/dL) (Figure 1). There were no significant differences in Zn levels between the patients and their corresponding siblings (P = 0.19) on matched pair analysis (Table 1). However, it was found that Zn levels were significantly correlated between patients with their corresponding siblings (r correlation coefficient = 0.63, P < 0.0001) (Figure 2).


Assessment of serum zinc levels of patients with thalassemia compared to their siblings.

El Missiry M, Hamed Hussein M, Khalid S, Yaqub N, Khan S, Itrat F, Uderzo C, Faulkner L - Anemia (2014)

Correlation between patients' serum Zn values. Levels correlated positively with corresponding (r = 0.635, P < 0.001).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150402&req=5

fig2: Correlation between patients' serum Zn values. Levels correlated positively with corresponding (r = 0.635, P < 0.001).
Mentions: Median patient age was 4.5 years (ranging from 1 to 10.6 years) and median sibling age was 7.3 years (ranging from 1.1 to 17 years). Patients' serum Zn ranged from 10 μg/dL to 297 μg/dL (median 100 μg/dL), while siblings' serum Zn ranged from 13 μg/dL to 212 μg/dL (median 92 μg/dL) (Figure 1). There were no significant differences in Zn levels between the patients and their corresponding siblings (P = 0.19) on matched pair analysis (Table 1). However, it was found that Zn levels were significantly correlated between patients with their corresponding siblings (r correlation coefficient = 0.63, P < 0.0001) (Figure 2).

Bottom Line: Serum Zn levels and anthropometric data measures were compared among siblings.There was no significant difference between the two groups.Patients' serum Zn values correlated with their siblings' values.

View Article: PubMed Central - PubMed

Affiliation: Cure2Children Foundation, Via Marconi 30, 50131 Florence, Italy.

ABSTRACT
Zinc (Zn) is essential for appropriate growth and proper immune function, both of which may be impaired in thalassemia children. Factors that can affect serum Zn levels in these patients may be related to their disease or treatment or nutritional causes. We assessed the serum Zn levels of children with thalassemia paired with a sibling. Zn levels were obtained from 30 children in Islamabad, Pakistan. Serum Zn levels and anthropometric data measures were compared among siblings. Thalassemia patients' median age was 4.5 years (range 1-10.6 years) and siblings was 7.8 years (range 1.1-17 years). The median serum Zn levels for both groups were within normal range: 100 μg/dL (10 μg/dL-297 μg/dL) for patients and 92 μg/dL (13 μg/dL-212 μg/dL) for siblings. There was no significant difference between the two groups. Patients' serum Zn values correlated positively with their corresponding siblings (r = 0.635, P < 0.001). There were no correlations between patients' Zn levels, height for age Z-scores, serum ferritin levels, chelation, or blood counts (including both total leukocyte and absolute lymphocyte counts). Patients' serum Zn values correlated with their siblings' values. In this study, patients with thalassemia do not seem to have disease-related Zn deficiency.

No MeSH data available.


Related in: MedlinePlus