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Volterra dendritic stimulus processors and biophysical spike generators with intrinsic noise sources.

Lazar AA, Zhou Y - Front Comput Neurosci (2014)

Bottom Line: For single-input multi-output neural circuit models with feedforward, feedback and cross-feedback DSPs cascaded with BSGs we theoretically analyze the effect of noise sources on stimulus decoding.Building on a key duality property, the effect of noise parameters on the precision of the functional identification of the complete neural circuit with DSP/BSG neuron models is given.We demonstrate through extensive simulations the effects of noise on encoding stimuli with circuits that include neuron models that are akin to those commonly seen in sensory systems, e.g., complex cells in V1.

View Article: PubMed Central - PubMed

Affiliation: Department of Electrical Engineering, Columbia University New York, NY, USA.

ABSTRACT
We consider a class of neural circuit models with internal noise sources arising in sensory systems. The basic neuron model in these circuits consists of a dendritic stimulus processor (DSP) cascaded with a biophysical spike generator (BSG). The dendritic stimulus processor is modeled as a set of nonlinear operators that are assumed to have a Volterra series representation. Biophysical point neuron models, such as the Hodgkin-Huxley neuron, are used to model the spike generator. We address the question of how intrinsic noise sources affect the precision in encoding and decoding of sensory stimuli and the functional identification of its sensory circuits. We investigate two intrinsic noise sources arising (i) in the active dendritic trees underlying the DSPs, and (ii) in the ion channels of the BSGs. Noise in dendritic stimulus processing arises from a combined effect of variability in synaptic transmission and dendritic interactions. Channel noise arises in the BSGs due to the fluctuation of the number of the active ion channels. Using a stochastic differential equations formalism we show that encoding with a neuron model consisting of a nonlinear DSP cascaded with a BSG with intrinsic noise sources can be treated as generalized sampling with noisy measurements. For single-input multi-output neural circuit models with feedforward, feedback and cross-feedback DSPs cascaded with BSGs we theoretically analyze the effect of noise sources on stimulus decoding. Building on a key duality property, the effect of noise parameters on the precision of the functional identification of the complete neural circuit with DSP/BSG neuron models is given. We demonstrate through extensive simulations the effects of noise on encoding stimuli with circuits that include neuron models that are akin to those commonly seen in sensory systems, e.g., complex cells in V1.

No MeSH data available.


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SNR of identified DSP kernels. The BSG is described by the Hodgkin-Huxley equations with a finite number of ion channels and NK = 0.3NNa.
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Figure 10: SNR of identified DSP kernels. The BSG is described by the Hodgkin-Huxley equations with a finite number of ion channels and NK = 0.3NNa.

Mentions: Second, we investigated the identification of DSPs for a BSG noise model already described in Section 3.3.3. Figure 10 shows the SNR of the identified DSP kernels across a different number of sodium channels NNa while NK = 0.3NNa. The SNR plots suggest that the identification quality increases as more ion channels are present in the BSGs.


Volterra dendritic stimulus processors and biophysical spike generators with intrinsic noise sources.

Lazar AA, Zhou Y - Front Comput Neurosci (2014)

SNR of identified DSP kernels. The BSG is described by the Hodgkin-Huxley equations with a finite number of ion channels and NK = 0.3NNa.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150400&req=5

Figure 10: SNR of identified DSP kernels. The BSG is described by the Hodgkin-Huxley equations with a finite number of ion channels and NK = 0.3NNa.
Mentions: Second, we investigated the identification of DSPs for a BSG noise model already described in Section 3.3.3. Figure 10 shows the SNR of the identified DSP kernels across a different number of sodium channels NNa while NK = 0.3NNa. The SNR plots suggest that the identification quality increases as more ion channels are present in the BSGs.

Bottom Line: For single-input multi-output neural circuit models with feedforward, feedback and cross-feedback DSPs cascaded with BSGs we theoretically analyze the effect of noise sources on stimulus decoding.Building on a key duality property, the effect of noise parameters on the precision of the functional identification of the complete neural circuit with DSP/BSG neuron models is given.We demonstrate through extensive simulations the effects of noise on encoding stimuli with circuits that include neuron models that are akin to those commonly seen in sensory systems, e.g., complex cells in V1.

View Article: PubMed Central - PubMed

Affiliation: Department of Electrical Engineering, Columbia University New York, NY, USA.

ABSTRACT
We consider a class of neural circuit models with internal noise sources arising in sensory systems. The basic neuron model in these circuits consists of a dendritic stimulus processor (DSP) cascaded with a biophysical spike generator (BSG). The dendritic stimulus processor is modeled as a set of nonlinear operators that are assumed to have a Volterra series representation. Biophysical point neuron models, such as the Hodgkin-Huxley neuron, are used to model the spike generator. We address the question of how intrinsic noise sources affect the precision in encoding and decoding of sensory stimuli and the functional identification of its sensory circuits. We investigate two intrinsic noise sources arising (i) in the active dendritic trees underlying the DSPs, and (ii) in the ion channels of the BSGs. Noise in dendritic stimulus processing arises from a combined effect of variability in synaptic transmission and dendritic interactions. Channel noise arises in the BSGs due to the fluctuation of the number of the active ion channels. Using a stochastic differential equations formalism we show that encoding with a neuron model consisting of a nonlinear DSP cascaded with a BSG with intrinsic noise sources can be treated as generalized sampling with noisy measurements. For single-input multi-output neural circuit models with feedforward, feedback and cross-feedback DSPs cascaded with BSGs we theoretically analyze the effect of noise sources on stimulus decoding. Building on a key duality property, the effect of noise parameters on the precision of the functional identification of the complete neural circuit with DSP/BSG neuron models is given. We demonstrate through extensive simulations the effects of noise on encoding stimuli with circuits that include neuron models that are akin to those commonly seen in sensory systems, e.g., complex cells in V1.

No MeSH data available.


Related in: MedlinePlus