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Aspiration cytology in the preoperative diagnosis of ganglioneuroma presenting as a neck mass.

Bhadarge PS, Poflee SV - J Cytol (2014)

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India.

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Sir, Ganglioneuroma (GN) is a rare, fully differentiated, embryonal neural tumor of the sympathetic chain... GN presenting as a neck mass is uncommon and diagnosis on cytology is rarely described... A neuroblastic component was absent in the multiple sections studied [Figure 1]... Thus, the cytological diagnosis was confirmed on histopathological examination... The tumor showed the characteristic cytological features of GN... Absence of the primitive, round-cell component ruled out the possibility of ganglioneuroblastoma and other childhood round-cell tumors... Excision is the only treatment modality for GN... In rare cases, excision of the cervical GN could lead to postoperative Horner's syndrome... Our patient had no postoperative complications... In conclusion, a cytologist may encounter GN at uncommon locations and in varied age groups, but most of the times cytological features are distinctive enough to suggest an accurate preoperative diagnosis on FNAC, which helps in the proper management of the patient.

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Microphotograph of the cytology smears showing fibrillary stroma with schwann cells (H and E, ×400). Upper left inset-cluster of ganglion cells (H and E, ×400). Lower right inset-multinucleate ganglion cell (H and E, ×400)
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Figure 2: Microphotograph of the cytology smears showing fibrillary stroma with schwann cells (H and E, ×400). Upper left inset-cluster of ganglion cells (H and E, ×400). Lower right inset-multinucleate ganglion cell (H and E, ×400)

Mentions: Fine needle aspiration cytology (FNAC) was performed from multiple sites and the smears were stained with hematoxylin and eosin stain. The cytology smears yielded good cellularity and showed a biphasic pattern of large polyhedral cells in the fibrillary stroma and a few spindle-shaped cells, with cigar-shaped nuclei. The large cells had abundant, dense, eosinophilic cytoplasm, and single or multiple nuclei with prominent nucleoli [Figure 2 upper and lower inset]. They were identified as ganglion cells. The spindle cells were mature schwann cells. None of the smears showed presence of primitive round cells. With the characteristic bimodal cell population, a cytological diagnosis of ganglioneuroma was made.


Aspiration cytology in the preoperative diagnosis of ganglioneuroma presenting as a neck mass.

Bhadarge PS, Poflee SV - J Cytol (2014)

Microphotograph of the cytology smears showing fibrillary stroma with schwann cells (H and E, ×400). Upper left inset-cluster of ganglion cells (H and E, ×400). Lower right inset-multinucleate ganglion cell (H and E, ×400)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150346&req=5

Figure 2: Microphotograph of the cytology smears showing fibrillary stroma with schwann cells (H and E, ×400). Upper left inset-cluster of ganglion cells (H and E, ×400). Lower right inset-multinucleate ganglion cell (H and E, ×400)
Mentions: Fine needle aspiration cytology (FNAC) was performed from multiple sites and the smears were stained with hematoxylin and eosin stain. The cytology smears yielded good cellularity and showed a biphasic pattern of large polyhedral cells in the fibrillary stroma and a few spindle-shaped cells, with cigar-shaped nuclei. The large cells had abundant, dense, eosinophilic cytoplasm, and single or multiple nuclei with prominent nucleoli [Figure 2 upper and lower inset]. They were identified as ganglion cells. The spindle cells were mature schwann cells. None of the smears showed presence of primitive round cells. With the characteristic bimodal cell population, a cytological diagnosis of ganglioneuroma was made.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Sir, Ganglioneuroma (GN) is a rare, fully differentiated, embryonal neural tumor of the sympathetic chain... GN presenting as a neck mass is uncommon and diagnosis on cytology is rarely described... A neuroblastic component was absent in the multiple sections studied [Figure 1]... Thus, the cytological diagnosis was confirmed on histopathological examination... The tumor showed the characteristic cytological features of GN... Absence of the primitive, round-cell component ruled out the possibility of ganglioneuroblastoma and other childhood round-cell tumors... Excision is the only treatment modality for GN... In rare cases, excision of the cervical GN could lead to postoperative Horner's syndrome... Our patient had no postoperative complications... In conclusion, a cytologist may encounter GN at uncommon locations and in varied age groups, but most of the times cytological features are distinctive enough to suggest an accurate preoperative diagnosis on FNAC, which helps in the proper management of the patient.

No MeSH data available.


Related in: MedlinePlus