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Aspiration cytology in the preoperative diagnosis of ganglioneuroma presenting as a neck mass.

Bhadarge PS, Poflee SV - J Cytol (2014)

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India.

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Sir, Ganglioneuroma (GN) is a rare, fully differentiated, embryonal neural tumor of the sympathetic chain... GN presenting as a neck mass is uncommon and diagnosis on cytology is rarely described... A neuroblastic component was absent in the multiple sections studied [Figure 1]... Thus, the cytological diagnosis was confirmed on histopathological examination... The tumor showed the characteristic cytological features of GN... Absence of the primitive, round-cell component ruled out the possibility of ganglioneuroblastoma and other childhood round-cell tumors... Excision is the only treatment modality for GN... In rare cases, excision of the cervical GN could lead to postoperative Horner's syndrome... Our patient had no postoperative complications... In conclusion, a cytologist may encounter GN at uncommon locations and in varied age groups, but most of the times cytological features are distinctive enough to suggest an accurate preoperative diagnosis on FNAC, which helps in the proper management of the patient.

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Microphotograph showing clusters of ganglion cells admixed with neurofibrillary stroma (H and E, ×400). Inset-Diffuse mass on the left lateral side of the neck
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Figure 1: Microphotograph showing clusters of ganglion cells admixed with neurofibrillary stroma (H and E, ×400). Inset-Diffuse mass on the left lateral side of the neck

Mentions: Ganglioneuroma (GN) is a rare, fully differentiated, embryonal neural tumor of the sympathetic chain. GN presenting as a neck mass is uncommon and diagnosis on cytology is rarely described.[1] We present a case of ganglioneuroma in an eleven-year-old, prepubertal, female child, who presented with a slowly growing neck mass (for seven years). On account of the large neck mass present since early childhood, cystic hygroma was suspected clinically. However, the patient was referred for preoperative cytology. The mass was diffuse, about 10 × 6 cm, and occupying the entire left side of the neck [Figure 1, inset]. It was firm, non-fluctuant, nontender, and not moving with deglutition or protrusion of the tongue.


Aspiration cytology in the preoperative diagnosis of ganglioneuroma presenting as a neck mass.

Bhadarge PS, Poflee SV - J Cytol (2014)

Microphotograph showing clusters of ganglion cells admixed with neurofibrillary stroma (H and E, ×400). Inset-Diffuse mass on the left lateral side of the neck
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150346&req=5

Figure 1: Microphotograph showing clusters of ganglion cells admixed with neurofibrillary stroma (H and E, ×400). Inset-Diffuse mass on the left lateral side of the neck
Mentions: Ganglioneuroma (GN) is a rare, fully differentiated, embryonal neural tumor of the sympathetic chain. GN presenting as a neck mass is uncommon and diagnosis on cytology is rarely described.[1] We present a case of ganglioneuroma in an eleven-year-old, prepubertal, female child, who presented with a slowly growing neck mass (for seven years). On account of the large neck mass present since early childhood, cystic hygroma was suspected clinically. However, the patient was referred for preoperative cytology. The mass was diffuse, about 10 × 6 cm, and occupying the entire left side of the neck [Figure 1, inset]. It was firm, non-fluctuant, nontender, and not moving with deglutition or protrusion of the tongue.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Sir, Ganglioneuroma (GN) is a rare, fully differentiated, embryonal neural tumor of the sympathetic chain... GN presenting as a neck mass is uncommon and diagnosis on cytology is rarely described... A neuroblastic component was absent in the multiple sections studied [Figure 1]... Thus, the cytological diagnosis was confirmed on histopathological examination... The tumor showed the characteristic cytological features of GN... Absence of the primitive, round-cell component ruled out the possibility of ganglioneuroblastoma and other childhood round-cell tumors... Excision is the only treatment modality for GN... In rare cases, excision of the cervical GN could lead to postoperative Horner's syndrome... Our patient had no postoperative complications... In conclusion, a cytologist may encounter GN at uncommon locations and in varied age groups, but most of the times cytological features are distinctive enough to suggest an accurate preoperative diagnosis on FNAC, which helps in the proper management of the patient.

No MeSH data available.


Related in: MedlinePlus