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Extramedullary plasmacytoma of thyroid - a mimicker of medullary carcinoma at fine needle aspiration cytology: A case report.

Bhat V, Shariff S, Reddy RA - J Cytol (2014)

Bottom Line: A rare case of extra medullary plasmacytoma (EMP) of thyroid gland in a 60 year old male, occurring against a background of Hashimoto's thyroiditis is reported.Considering these findings we gave a diagnosis of medullary carcinoma.Immunohistochemistry on the histology sections confirmed the diagnosis of solitary plasmacytoma of thyroid against a background of Hashimoto's thyroiditis.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, MVJ Medical College and Research Hospital, Bangalore, Karnataka, India.

ABSTRACT
A rare case of extra medullary plasmacytoma (EMP) of thyroid gland in a 60 year old male, occurring against a background of Hashimoto's thyroiditis is reported. The fine needle aspiration cytology (FNAC) initially done as an outpatient procedure, showed atypical epithelial cells on a background of amyloid. Considering these findings we gave a diagnosis of medullary carcinoma. Histology of the total thyroidectomy specimen showed an extensive infiltration of neoplastic plasma cells against a background of Hashimoto's thyroiditis, with a bizarre Hurthle cell change. Immunohistochemistry on the histology sections confirmed the diagnosis of solitary plasmacytoma of thyroid against a background of Hashimoto's thyroiditis.

No MeSH data available.


Related in: MedlinePlus

Neoplastic cells showing diffuse cytoplasmic positivity for CD138 indicating plasma cell diff erentiati on (IHC, ×400)
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F2c: Neoplastic cells showing diffuse cytoplasmic positivity for CD138 indicating plasma cell diff erentiati on (IHC, ×400)

Mentions: Histopathology: The multiple sections studied, revealed diffuse atypical plasma cells in sheets effacing the normal thyroid parenchyma [Figure 2b]. The intervening areas and thyroid tissue at the periphery showed Hashimoto thyroiditis, with extensive oncocytic change and bizarre nuclear changes. Numerous lymphoepithelial lesions were also noted, with follicular colonization of acini by lymphocytes. Amorphous material, consistent with an amyloid, was identified amidst the neoplastic cells. A diagnosis of plasmacytoma of the thyroid gland was made on histology. A close differential considered on histology was marginal zone lymphoma with extensive plasma cell differentiation. Immunohistochemistry revealed plasmacytoid cells with diffuse positivity for CD138 [Figure 2c], and also cytoplasmic positivity for the Kappa light chain. The tumor cells were negative for CD19 [Figure 2d] and CD20. On the basis of immunohistochemistry a final diagnosis of extramedullary solitary plasmacytoma (ESP) of the thyroid was made, after the workup was found to be negative for multiple myeloma.


Extramedullary plasmacytoma of thyroid - a mimicker of medullary carcinoma at fine needle aspiration cytology: A case report.

Bhat V, Shariff S, Reddy RA - J Cytol (2014)

Neoplastic cells showing diffuse cytoplasmic positivity for CD138 indicating plasma cell diff erentiati on (IHC, ×400)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150345&req=5

F2c: Neoplastic cells showing diffuse cytoplasmic positivity for CD138 indicating plasma cell diff erentiati on (IHC, ×400)
Mentions: Histopathology: The multiple sections studied, revealed diffuse atypical plasma cells in sheets effacing the normal thyroid parenchyma [Figure 2b]. The intervening areas and thyroid tissue at the periphery showed Hashimoto thyroiditis, with extensive oncocytic change and bizarre nuclear changes. Numerous lymphoepithelial lesions were also noted, with follicular colonization of acini by lymphocytes. Amorphous material, consistent with an amyloid, was identified amidst the neoplastic cells. A diagnosis of plasmacytoma of the thyroid gland was made on histology. A close differential considered on histology was marginal zone lymphoma with extensive plasma cell differentiation. Immunohistochemistry revealed plasmacytoid cells with diffuse positivity for CD138 [Figure 2c], and also cytoplasmic positivity for the Kappa light chain. The tumor cells were negative for CD19 [Figure 2d] and CD20. On the basis of immunohistochemistry a final diagnosis of extramedullary solitary plasmacytoma (ESP) of the thyroid was made, after the workup was found to be negative for multiple myeloma.

Bottom Line: A rare case of extra medullary plasmacytoma (EMP) of thyroid gland in a 60 year old male, occurring against a background of Hashimoto's thyroiditis is reported.Considering these findings we gave a diagnosis of medullary carcinoma.Immunohistochemistry on the histology sections confirmed the diagnosis of solitary plasmacytoma of thyroid against a background of Hashimoto's thyroiditis.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, MVJ Medical College and Research Hospital, Bangalore, Karnataka, India.

ABSTRACT
A rare case of extra medullary plasmacytoma (EMP) of thyroid gland in a 60 year old male, occurring against a background of Hashimoto's thyroiditis is reported. The fine needle aspiration cytology (FNAC) initially done as an outpatient procedure, showed atypical epithelial cells on a background of amyloid. Considering these findings we gave a diagnosis of medullary carcinoma. Histology of the total thyroidectomy specimen showed an extensive infiltration of neoplastic plasma cells against a background of Hashimoto's thyroiditis, with a bizarre Hurthle cell change. Immunohistochemistry on the histology sections confirmed the diagnosis of solitary plasmacytoma of thyroid against a background of Hashimoto's thyroiditis.

No MeSH data available.


Related in: MedlinePlus