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Extramedullary plasmacytoma of thyroid - a mimicker of medullary carcinoma at fine needle aspiration cytology: A case report.

Bhat V, Shariff S, Reddy RA - J Cytol (2014)

Bottom Line: A rare case of extra medullary plasmacytoma (EMP) of thyroid gland in a 60 year old male, occurring against a background of Hashimoto's thyroiditis is reported.Considering these findings we gave a diagnosis of medullary carcinoma.Immunohistochemistry on the histology sections confirmed the diagnosis of solitary plasmacytoma of thyroid against a background of Hashimoto's thyroiditis.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, MVJ Medical College and Research Hospital, Bangalore, Karnataka, India.

ABSTRACT
A rare case of extra medullary plasmacytoma (EMP) of thyroid gland in a 60 year old male, occurring against a background of Hashimoto's thyroiditis is reported. The fine needle aspiration cytology (FNAC) initially done as an outpatient procedure, showed atypical epithelial cells on a background of amyloid. Considering these findings we gave a diagnosis of medullary carcinoma. Histology of the total thyroidectomy specimen showed an extensive infiltration of neoplastic plasma cells against a background of Hashimoto's thyroiditis, with a bizarre Hurthle cell change. Immunohistochemistry on the histology sections confirmed the diagnosis of solitary plasmacytoma of thyroid against a background of Hashimoto's thyroiditis.

No MeSH data available.


Related in: MedlinePlus

Cut surface of the total thyroidectomy specimen showing a lobulated fleshy appearance
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F2a: Cut surface of the total thyroidectomy specimen showing a lobulated fleshy appearance

Mentions: A possibility of an epithelial neoplasm, either medullary carcinoma (pleomorphic variant) or a follicular variant of papillary carcinoma was given. This was due to the presence of pleomorphic epithelial cells arranged in groups, acini, and papillaroid structures. However, due to the associated amyloid, a strong possibility of medullary carcinoma over papillary carcinoma was considered. Based on this diagnosis, the patient underwent total thyroidectomy. Gross examination of the thyroidectomy specimen showed the right lobe to be with an isthmus measuring 7 × 5 × 4 cm and the left lobe measuring 5 × 4 × 3 cm. The cut surfaces of both were nodular and fleshy in appearance [Figure 2a].


Extramedullary plasmacytoma of thyroid - a mimicker of medullary carcinoma at fine needle aspiration cytology: A case report.

Bhat V, Shariff S, Reddy RA - J Cytol (2014)

Cut surface of the total thyroidectomy specimen showing a lobulated fleshy appearance
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150345&req=5

F2a: Cut surface of the total thyroidectomy specimen showing a lobulated fleshy appearance
Mentions: A possibility of an epithelial neoplasm, either medullary carcinoma (pleomorphic variant) or a follicular variant of papillary carcinoma was given. This was due to the presence of pleomorphic epithelial cells arranged in groups, acini, and papillaroid structures. However, due to the associated amyloid, a strong possibility of medullary carcinoma over papillary carcinoma was considered. Based on this diagnosis, the patient underwent total thyroidectomy. Gross examination of the thyroidectomy specimen showed the right lobe to be with an isthmus measuring 7 × 5 × 4 cm and the left lobe measuring 5 × 4 × 3 cm. The cut surfaces of both were nodular and fleshy in appearance [Figure 2a].

Bottom Line: A rare case of extra medullary plasmacytoma (EMP) of thyroid gland in a 60 year old male, occurring against a background of Hashimoto's thyroiditis is reported.Considering these findings we gave a diagnosis of medullary carcinoma.Immunohistochemistry on the histology sections confirmed the diagnosis of solitary plasmacytoma of thyroid against a background of Hashimoto's thyroiditis.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, MVJ Medical College and Research Hospital, Bangalore, Karnataka, India.

ABSTRACT
A rare case of extra medullary plasmacytoma (EMP) of thyroid gland in a 60 year old male, occurring against a background of Hashimoto's thyroiditis is reported. The fine needle aspiration cytology (FNAC) initially done as an outpatient procedure, showed atypical epithelial cells on a background of amyloid. Considering these findings we gave a diagnosis of medullary carcinoma. Histology of the total thyroidectomy specimen showed an extensive infiltration of neoplastic plasma cells against a background of Hashimoto's thyroiditis, with a bizarre Hurthle cell change. Immunohistochemistry on the histology sections confirmed the diagnosis of solitary plasmacytoma of thyroid against a background of Hashimoto's thyroiditis.

No MeSH data available.


Related in: MedlinePlus