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Extramedullary plasmacytoma of thyroid - a mimicker of medullary carcinoma at fine needle aspiration cytology: A case report.

Bhat V, Shariff S, Reddy RA - J Cytol (2014)

Bottom Line: A rare case of extra medullary plasmacytoma (EMP) of thyroid gland in a 60 year old male, occurring against a background of Hashimoto's thyroiditis is reported.Considering these findings we gave a diagnosis of medullary carcinoma.Immunohistochemistry on the histology sections confirmed the diagnosis of solitary plasmacytoma of thyroid against a background of Hashimoto's thyroiditis.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, MVJ Medical College and Research Hospital, Bangalore, Karnataka, India.

ABSTRACT
A rare case of extra medullary plasmacytoma (EMP) of thyroid gland in a 60 year old male, occurring against a background of Hashimoto's thyroiditis is reported. The fine needle aspiration cytology (FNAC) initially done as an outpatient procedure, showed atypical epithelial cells on a background of amyloid. Considering these findings we gave a diagnosis of medullary carcinoma. Histology of the total thyroidectomy specimen showed an extensive infiltration of neoplastic plasma cells against a background of Hashimoto's thyroiditis, with a bizarre Hurthle cell change. Immunohistochemistry on the histology sections confirmed the diagnosis of solitary plasmacytoma of thyroid against a background of Hashimoto's thyroiditis.

No MeSH data available.


Related in: MedlinePlus

Cellular aspirate with acinar cells, papillaroid clusters, and nuclei with grooves (H and E, ×200)
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F1a: Cellular aspirate with acinar cells, papillaroid clusters, and nuclei with grooves (H and E, ×200)

Mentions: The FNAC revealed a cellular aspirate composed of cells arranged in numerous acini, loose clusters, pseudopapillae, as well as singly dispersed [Figure 1a]. The cells were round to ovoid, with enlarged nuclei and fine chromatin. Many cells showed nuclear grooves as well as marked anisonucleosis, with occasional intranuclear cytoplasmic inclusions [Figure 1c]. The cytoplasm was abundant, pink, and granular in most of the cells [Figure 1b]. The background showed a few lymphocytes and spindle-shaped cells. Occasional multinucleate giant cells were observed. A pink amorphous acellular material was identified as large blobs and stained positive for Congo red [Figure 1d]. It showed an apple green birefringence on polarising microscopy.


Extramedullary plasmacytoma of thyroid - a mimicker of medullary carcinoma at fine needle aspiration cytology: A case report.

Bhat V, Shariff S, Reddy RA - J Cytol (2014)

Cellular aspirate with acinar cells, papillaroid clusters, and nuclei with grooves (H and E, ×200)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150345&req=5

F1a: Cellular aspirate with acinar cells, papillaroid clusters, and nuclei with grooves (H and E, ×200)
Mentions: The FNAC revealed a cellular aspirate composed of cells arranged in numerous acini, loose clusters, pseudopapillae, as well as singly dispersed [Figure 1a]. The cells were round to ovoid, with enlarged nuclei and fine chromatin. Many cells showed nuclear grooves as well as marked anisonucleosis, with occasional intranuclear cytoplasmic inclusions [Figure 1c]. The cytoplasm was abundant, pink, and granular in most of the cells [Figure 1b]. The background showed a few lymphocytes and spindle-shaped cells. Occasional multinucleate giant cells were observed. A pink amorphous acellular material was identified as large blobs and stained positive for Congo red [Figure 1d]. It showed an apple green birefringence on polarising microscopy.

Bottom Line: A rare case of extra medullary plasmacytoma (EMP) of thyroid gland in a 60 year old male, occurring against a background of Hashimoto's thyroiditis is reported.Considering these findings we gave a diagnosis of medullary carcinoma.Immunohistochemistry on the histology sections confirmed the diagnosis of solitary plasmacytoma of thyroid against a background of Hashimoto's thyroiditis.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, MVJ Medical College and Research Hospital, Bangalore, Karnataka, India.

ABSTRACT
A rare case of extra medullary plasmacytoma (EMP) of thyroid gland in a 60 year old male, occurring against a background of Hashimoto's thyroiditis is reported. The fine needle aspiration cytology (FNAC) initially done as an outpatient procedure, showed atypical epithelial cells on a background of amyloid. Considering these findings we gave a diagnosis of medullary carcinoma. Histology of the total thyroidectomy specimen showed an extensive infiltration of neoplastic plasma cells against a background of Hashimoto's thyroiditis, with a bizarre Hurthle cell change. Immunohistochemistry on the histology sections confirmed the diagnosis of solitary plasmacytoma of thyroid against a background of Hashimoto's thyroiditis.

No MeSH data available.


Related in: MedlinePlus