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Cutaneous metastasis of transitional cell carcinoma of the urinary bladder: Cytological aspect.

Narayana MA, Patnayak R, Rukmangadha N, Chowhan AK, Kottu R, Phaneendra BV - J Cytol (2014)

Bottom Line: This case report describes a 51-year-old male who presented with multiple cutaneous metastases arising from high grade transitional cell carcinoma bladder with lamina propria invasion.The prominent cytological features include medium sized to large pleomorphic cells with irregular nuclear outlines, coarse chromatin pattern, and tumor giant cells.An awareness of this rare clinical entity and high index of suspicion is needed for diagnosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.

ABSTRACT
Cutaneous metastasis from transitional cell carcinoma urinary bladder is a rare clinical entity associated with poor prognosis. This case report describes a 51-year-old male who presented with multiple cutaneous metastases arising from high grade transitional cell carcinoma bladder with lamina propria invasion. The prominent cytological features include medium sized to large pleomorphic cells with irregular nuclear outlines, coarse chromatin pattern, and tumor giant cells. An awareness of this rare clinical entity and high index of suspicion is needed for diagnosis.

No MeSH data available.


Related in: MedlinePlus

Tumor cells with large hyper chromatic nuclei with irregular nuclear outlines and admixed tumor giant cells (H and E, ×400) (inset: Pap, ×400)
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Figure 1: Tumor cells with large hyper chromatic nuclei with irregular nuclear outlines and admixed tumor giant cells (H and E, ×400) (inset: Pap, ×400)

Mentions: Fine-needle aspiration cytology (FNAC) was performed from left subscapular and umbilical region subcutaneous swellings. The smears were richly cellular and revealed identical morphology. They comprised moderate to markedly pleomorphic cells arranged discretely with large hyper chromatic nuclei displaying irregular nuclear outlines and also presence of tumor giant cells. Due to these features, a cytological diagnosis of metastatic malignancy was suggested [Figure 1].


Cutaneous metastasis of transitional cell carcinoma of the urinary bladder: Cytological aspect.

Narayana MA, Patnayak R, Rukmangadha N, Chowhan AK, Kottu R, Phaneendra BV - J Cytol (2014)

Tumor cells with large hyper chromatic nuclei with irregular nuclear outlines and admixed tumor giant cells (H and E, ×400) (inset: Pap, ×400)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150344&req=5

Figure 1: Tumor cells with large hyper chromatic nuclei with irregular nuclear outlines and admixed tumor giant cells (H and E, ×400) (inset: Pap, ×400)
Mentions: Fine-needle aspiration cytology (FNAC) was performed from left subscapular and umbilical region subcutaneous swellings. The smears were richly cellular and revealed identical morphology. They comprised moderate to markedly pleomorphic cells arranged discretely with large hyper chromatic nuclei displaying irregular nuclear outlines and also presence of tumor giant cells. Due to these features, a cytological diagnosis of metastatic malignancy was suggested [Figure 1].

Bottom Line: This case report describes a 51-year-old male who presented with multiple cutaneous metastases arising from high grade transitional cell carcinoma bladder with lamina propria invasion.The prominent cytological features include medium sized to large pleomorphic cells with irregular nuclear outlines, coarse chromatin pattern, and tumor giant cells.An awareness of this rare clinical entity and high index of suspicion is needed for diagnosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.

ABSTRACT
Cutaneous metastasis from transitional cell carcinoma urinary bladder is a rare clinical entity associated with poor prognosis. This case report describes a 51-year-old male who presented with multiple cutaneous metastases arising from high grade transitional cell carcinoma bladder with lamina propria invasion. The prominent cytological features include medium sized to large pleomorphic cells with irregular nuclear outlines, coarse chromatin pattern, and tumor giant cells. An awareness of this rare clinical entity and high index of suspicion is needed for diagnosis.

No MeSH data available.


Related in: MedlinePlus