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Lipomatous pleomorphic adenoma in the hard palate: Report of a rare case with cyto-histo correlation and review.

Musayev J, Onal B, Hasanov A, Farzaliyev I - J Cytol (2014)

Bottom Line: Extensive lipomatous differentiation is very rare.Histopathological examination of the excision material displayed that more than 90% of the tumor was adipocytic in texture, containing scant epithelial and myoepithelial cells and chondromyxoid stromal fragments.LPA should be on the mental list of the (cyto)pathologist in differential diagnosis of lipomatous tumors or non-tumorous lipomatosis or carcinoma invasion in the adipose tissue of the minor salivary gland of the hard palate.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Azerbaijan Medical University, Baku, Republic of Azerbaijan.

ABSTRACT
Pleomorphic adenoma is the most common benign tumor of the salivary glands. They are usually composed of epithelial/myoepithelial cells and chondromyxoid stroma. Extensive lipomatous differentiation is very rare. We report a case of lipomatous pleomorphic adenoma (LPA) that presented with a mass in the hard palate of a 32-year-old woman. The fine-needle aspiration cytology material was reported as benign cytology consistent with adenoma with major adipocytic component. Histopathological examination of the excision material displayed that more than 90% of the tumor was adipocytic in texture, containing scant epithelial and myoepithelial cells and chondromyxoid stromal fragments. Preoperative cytodiagnosis of lipomatous pleomorphic adenoma on FNA is based on cytomorphology intimately associated pleomorphic adenomatous and lipomatous tissue elements. LPA should be on the mental list of the (cyto)pathologist in differential diagnosis of lipomatous tumors or non-tumorous lipomatosis or carcinoma invasion in the adipose tissue of the minor salivary gland of the hard palate.

No MeSH data available.


Related in: MedlinePlus

Lesion manifested as a mass in hard palate
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Figure 1: Lesion manifested as a mass in hard palate

Mentions: An oral, asymptomatic, slowly growing mass was detected in the submucosa of the hard palate of a 32-year-old woman who was admitted to the Department of Oral and Maxillofacial Surgery of Azerbaijan Medical University [Figure 1]. FNA was performed by using 24-gauge needle and 10-mL syringe attached to the syringe-holder and two direct smears were prepared by the (cyto)pathologist. One smear was air-dried for May-Grünwald-Giemsa (MGG) staining while the other one was alcohol-fixed for Papanicolaou dye. Abundant mature adipose cells, and some epithelial/myoepithelial cells and metachromatically staining fibrillary stromal fragments were observed [Figure 2a,b]. FNA material was reported as benign cytology, being compatible with pleomorphic adenoma with adipose component, and the mass was excised. Macroscopically, the specimen was 20 × 18 × 14 mm in size, well-circumscribed, unilaterally mucosa-covered, yellow-colored on sectioning and nodular in appearance. In histopathological examination of completely sampled material, more than 90% of the tumor was composed of mature adipose tissue consisting of univacuolar adipocytes [Figure 2c,d]. Local islands and septa-forming epithelial/myoepithelial cells were identified within adipose component. No mitosis, cellular atypia or necrosis were encountered in either adipose component or epithelial/myoepithelial cells. No recurrence was observed during the 12-month follow-up of the well-circumscribed and totally excised mass.


Lipomatous pleomorphic adenoma in the hard palate: Report of a rare case with cyto-histo correlation and review.

Musayev J, Onal B, Hasanov A, Farzaliyev I - J Cytol (2014)

Lesion manifested as a mass in hard palate
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150340&req=5

Figure 1: Lesion manifested as a mass in hard palate
Mentions: An oral, asymptomatic, slowly growing mass was detected in the submucosa of the hard palate of a 32-year-old woman who was admitted to the Department of Oral and Maxillofacial Surgery of Azerbaijan Medical University [Figure 1]. FNA was performed by using 24-gauge needle and 10-mL syringe attached to the syringe-holder and two direct smears were prepared by the (cyto)pathologist. One smear was air-dried for May-Grünwald-Giemsa (MGG) staining while the other one was alcohol-fixed for Papanicolaou dye. Abundant mature adipose cells, and some epithelial/myoepithelial cells and metachromatically staining fibrillary stromal fragments were observed [Figure 2a,b]. FNA material was reported as benign cytology, being compatible with pleomorphic adenoma with adipose component, and the mass was excised. Macroscopically, the specimen was 20 × 18 × 14 mm in size, well-circumscribed, unilaterally mucosa-covered, yellow-colored on sectioning and nodular in appearance. In histopathological examination of completely sampled material, more than 90% of the tumor was composed of mature adipose tissue consisting of univacuolar adipocytes [Figure 2c,d]. Local islands and septa-forming epithelial/myoepithelial cells were identified within adipose component. No mitosis, cellular atypia or necrosis were encountered in either adipose component or epithelial/myoepithelial cells. No recurrence was observed during the 12-month follow-up of the well-circumscribed and totally excised mass.

Bottom Line: Extensive lipomatous differentiation is very rare.Histopathological examination of the excision material displayed that more than 90% of the tumor was adipocytic in texture, containing scant epithelial and myoepithelial cells and chondromyxoid stromal fragments.LPA should be on the mental list of the (cyto)pathologist in differential diagnosis of lipomatous tumors or non-tumorous lipomatosis or carcinoma invasion in the adipose tissue of the minor salivary gland of the hard palate.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Azerbaijan Medical University, Baku, Republic of Azerbaijan.

ABSTRACT
Pleomorphic adenoma is the most common benign tumor of the salivary glands. They are usually composed of epithelial/myoepithelial cells and chondromyxoid stroma. Extensive lipomatous differentiation is very rare. We report a case of lipomatous pleomorphic adenoma (LPA) that presented with a mass in the hard palate of a 32-year-old woman. The fine-needle aspiration cytology material was reported as benign cytology consistent with adenoma with major adipocytic component. Histopathological examination of the excision material displayed that more than 90% of the tumor was adipocytic in texture, containing scant epithelial and myoepithelial cells and chondromyxoid stromal fragments. Preoperative cytodiagnosis of lipomatous pleomorphic adenoma on FNA is based on cytomorphology intimately associated pleomorphic adenomatous and lipomatous tissue elements. LPA should be on the mental list of the (cyto)pathologist in differential diagnosis of lipomatous tumors or non-tumorous lipomatosis or carcinoma invasion in the adipose tissue of the minor salivary gland of the hard palate.

No MeSH data available.


Related in: MedlinePlus