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Ultrasound-guided aspiration cytology of retroperitoneal masses with histopathological corroboration: A study of 71 cases.

Chakrabarti I, Bhowmik S, Sinha MG, Bera P - J Cytol (2014)

Bottom Line: Out of 71 cases, 48 cases (67.6%) were found to be neoplastic.Some uncommon retroperitoneal lesions like adrenal myelolipoma, renal angiomyolipoma, Burkitt's lymphoma and adrenocortical carcinoma were found in our study.Guided FNAC could diagnose all the malignant lesions with 100% accuracy except in 2 cases of poorly differentiated carcinoma which came out to be non-Hodgkin lymphoma on subsequent biopsies.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, North Bengal Medical College, Sushrutanagar, Darjeeling, West Bengal, India.

ABSTRACT

Background: Diagnosis of retroperitoneal lesions is one of the most difficult areas in surgical pathology. Both primary and metastatic tumors can grow silently in retroperitoneum before the appearance of clinical signs and symptoms. Guided aspiration cytology has shown a promising role in diagnosis of lesions in this region.

Aims: This study was undertaken to evaluate the reliability of guided fine-needle aspiration cytology (FNAC) in the diagnosis of retroperitoneal masses and to study the spectrum of retroperitoneal lesions in a rural tertiary care hospital.

Materials and methods: This study was done on 71 patients presenting with retroperitoneal masses over a period of 20 months in a tertiary care hospital. Ultrasound-guided FNAC was done and the smears were stained by MGG and H and E stains. Histopathological corroboration could be done on all neoplastic lesions along with some non-neoplastic lesions.

Results: Out of 71 cases, 48 cases (67.6%) were found to be neoplastic. Malignant tumors (35 cases) were more common than benign ones (13 cases). Malignant lesions were predominantly composed of lesions of lymph node (17 cases i.e. 48.57%) followed by sarcomas (5 cases) and germ cell tumors. Some uncommon retroperitoneal lesions like adrenal myelolipoma, renal angiomyolipoma, Burkitt's lymphoma and adrenocortical carcinoma were found in our study. Guided FNAC could diagnose all the malignant lesions with 100% accuracy except in 2 cases of poorly differentiated carcinoma which came out to be non-Hodgkin lymphoma on subsequent biopsies.

Conclusion: Guided FNAC is an inexpensive, rapid and reliable method for diagnosis of retroperitoneal masses.

No MeSH data available.


Related in: MedlinePlus

(a) Aspirate from pleomorphic sarcoma with giant cells and lipoblast-like cells, suggestie of pleomorphic liposarcoma (MGG, ×400) (b) Chromophobe renal cell carcinoma showing a dual populatin of large cells with abundant eosinophilic cytoplasm with binucleation and another group of smaller cells (MGG, ×400); (c) aspirate from a case of Wilm's tumor showing mesenchymal differentiation (MGG, ×100). Inset shows epithelial differentiation in the form of tubules (H and E, ×400); (d) adrenal corcical carcinoma (MGG, ×100). Inset shows cytoplasmic vacuolation (MGG, ×400);
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Figure 2: (a) Aspirate from pleomorphic sarcoma with giant cells and lipoblast-like cells, suggestie of pleomorphic liposarcoma (MGG, ×400) (b) Chromophobe renal cell carcinoma showing a dual populatin of large cells with abundant eosinophilic cytoplasm with binucleation and another group of smaller cells (MGG, ×400); (c) aspirate from a case of Wilm's tumor showing mesenchymal differentiation (MGG, ×100). Inset shows epithelial differentiation in the form of tubules (H and E, ×400); (d) adrenal corcical carcinoma (MGG, ×100). Inset shows cytoplasmic vacuolation (MGG, ×400);

Mentions: Soft tissue sarcomas comprised of 5 cases (14.29% of the malignancies) -3 of the cases diagnosed as pleomorphic sarcomas [Figure 1d] were categorized histopathologically as pleomorphic liposarcomas (2 cases, 40%) and one case of malignant fibrous histiocytoma (MFH). In one case of pleomorphic sarcoma, the probability of pleomorphic liposarcoma was mentioned [Figure 2a], which was confirmed on histopathology. The cases of embryonal rhabdomyosarcoma and malignant peripheral nerve sheath tumor were also correctly diagnosed cytologically.


Ultrasound-guided aspiration cytology of retroperitoneal masses with histopathological corroboration: A study of 71 cases.

Chakrabarti I, Bhowmik S, Sinha MG, Bera P - J Cytol (2014)

(a) Aspirate from pleomorphic sarcoma with giant cells and lipoblast-like cells, suggestie of pleomorphic liposarcoma (MGG, ×400) (b) Chromophobe renal cell carcinoma showing a dual populatin of large cells with abundant eosinophilic cytoplasm with binucleation and another group of smaller cells (MGG, ×400); (c) aspirate from a case of Wilm's tumor showing mesenchymal differentiation (MGG, ×100). Inset shows epithelial differentiation in the form of tubules (H and E, ×400); (d) adrenal corcical carcinoma (MGG, ×100). Inset shows cytoplasmic vacuolation (MGG, ×400);
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150336&req=5

Figure 2: (a) Aspirate from pleomorphic sarcoma with giant cells and lipoblast-like cells, suggestie of pleomorphic liposarcoma (MGG, ×400) (b) Chromophobe renal cell carcinoma showing a dual populatin of large cells with abundant eosinophilic cytoplasm with binucleation and another group of smaller cells (MGG, ×400); (c) aspirate from a case of Wilm's tumor showing mesenchymal differentiation (MGG, ×100). Inset shows epithelial differentiation in the form of tubules (H and E, ×400); (d) adrenal corcical carcinoma (MGG, ×100). Inset shows cytoplasmic vacuolation (MGG, ×400);
Mentions: Soft tissue sarcomas comprised of 5 cases (14.29% of the malignancies) -3 of the cases diagnosed as pleomorphic sarcomas [Figure 1d] were categorized histopathologically as pleomorphic liposarcomas (2 cases, 40%) and one case of malignant fibrous histiocytoma (MFH). In one case of pleomorphic sarcoma, the probability of pleomorphic liposarcoma was mentioned [Figure 2a], which was confirmed on histopathology. The cases of embryonal rhabdomyosarcoma and malignant peripheral nerve sheath tumor were also correctly diagnosed cytologically.

Bottom Line: Out of 71 cases, 48 cases (67.6%) were found to be neoplastic.Some uncommon retroperitoneal lesions like adrenal myelolipoma, renal angiomyolipoma, Burkitt's lymphoma and adrenocortical carcinoma were found in our study.Guided FNAC could diagnose all the malignant lesions with 100% accuracy except in 2 cases of poorly differentiated carcinoma which came out to be non-Hodgkin lymphoma on subsequent biopsies.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, North Bengal Medical College, Sushrutanagar, Darjeeling, West Bengal, India.

ABSTRACT

Background: Diagnosis of retroperitoneal lesions is one of the most difficult areas in surgical pathology. Both primary and metastatic tumors can grow silently in retroperitoneum before the appearance of clinical signs and symptoms. Guided aspiration cytology has shown a promising role in diagnosis of lesions in this region.

Aims: This study was undertaken to evaluate the reliability of guided fine-needle aspiration cytology (FNAC) in the diagnosis of retroperitoneal masses and to study the spectrum of retroperitoneal lesions in a rural tertiary care hospital.

Materials and methods: This study was done on 71 patients presenting with retroperitoneal masses over a period of 20 months in a tertiary care hospital. Ultrasound-guided FNAC was done and the smears were stained by MGG and H and E stains. Histopathological corroboration could be done on all neoplastic lesions along with some non-neoplastic lesions.

Results: Out of 71 cases, 48 cases (67.6%) were found to be neoplastic. Malignant tumors (35 cases) were more common than benign ones (13 cases). Malignant lesions were predominantly composed of lesions of lymph node (17 cases i.e. 48.57%) followed by sarcomas (5 cases) and germ cell tumors. Some uncommon retroperitoneal lesions like adrenal myelolipoma, renal angiomyolipoma, Burkitt's lymphoma and adrenocortical carcinoma were found in our study. Guided FNAC could diagnose all the malignant lesions with 100% accuracy except in 2 cases of poorly differentiated carcinoma which came out to be non-Hodgkin lymphoma on subsequent biopsies.

Conclusion: Guided FNAC is an inexpensive, rapid and reliable method for diagnosis of retroperitoneal masses.

No MeSH data available.


Related in: MedlinePlus