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Years of life lost as a measure of cancer burden on a national level.

Brustugun OT, Møller B, Helland A - Br. J. Cancer (2014)

Bottom Line: Lung cancer caused almost as many YLL alone (22.1% of cancer-caused YLL) as colon, prostate and breast cancer combined (23.1%).From 1997 to 2012, cancer-caused YLL as a fraction of all YLL increased from 32.5% to 35.2%, but with major differences among diagnoses.Public health efforts and research funding should be explicitly directed at preventing premature deaths.

View Article: PubMed Central - PubMed

Affiliation: 1] Department of Oncology, Oslo University Hospital-The Norwegian Radium Hospital, Oslo, Norway [2] Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

ABSTRACT

Background: The severity of cancers is often measured in number of deaths. However, number of years of life lost (YLL) may be a more appropriate indicator of impact on society. Here we have calculated the YLL of adult cancers in Norway for the year 2012, as well as for the previous 15-year period.

Methods: Data on age composition, expected remaining years of life, total numbers of deaths and deaths due to cancer were retrieved from the National Census Agency Statistics Norway. YLL were calculated for both sexes aged 25-99 years based on each individual's age at death, and the expected remaining years of life at that age.

Results: Cancer deaths represented 25.8% of all adult deaths in 2012, with a lower fraction of females (28.7% in men and 23.1% in women), whereas cancer represented 35.2% of all YLL, with a higher fraction of females (32.8% in men and 37.8% in women). Females loose on average more life years to cancer than men (14.9 vs 12.7 years). Average YLL varied from 23.7 (cervical cancer) to 7.9 (prostate cancer). Lung cancer caused almost as many YLL alone (22.1% of cancer-caused YLL) as colon, prostate and breast cancer combined (23.1%). From 1997 to 2012, cancer-caused YLL as a fraction of all YLL increased from 32.5% to 35.2%, but with major differences among diagnoses.

Conclusions: Cancer is a major and increasing cause of premature deaths, and YLL may be a more accurate measure than number of deaths. Public health efforts and research funding should be explicitly directed at preventing premature deaths.

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Related in: MedlinePlus

Number of deaths of individual cancer types in Norway in 2012 as a percentage of all cancer deaths (y axis) and total YLL of the same cancer type as a percentage of all cancer-related YLL (x axis). The ratio of YLL (%) to deaths (%) (A) and the ratios (log scale) of YLL (%)/mortality (%) are shown for the 18 most frequent cancers (B).
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fig3: Number of deaths of individual cancer types in Norway in 2012 as a percentage of all cancer deaths (y axis) and total YLL of the same cancer type as a percentage of all cancer-related YLL (x axis). The ratio of YLL (%) to deaths (%) (A) and the ratios (log scale) of YLL (%)/mortality (%) are shown for the 18 most frequent cancers (B).

Mentions: The YLL of each cancer can be expressed as a percentage of the total YLL to cancers, and related to the number of deaths (mortality) of each cancer as a percentage of the total number of deaths of cancer. The results of these calculations indicate the relative difference, that is, the degree of imbalance between the YLL parameters and mortality parameters, and are shown in Figure 3A. For most cancer types, the YLL (%)/mortality (%) ratio is close to 1, but ranged from 0.58 (prostate, low relative YLL) to 1.72 (cervical cancer, high relative YLL) (Figure 3B). Lung cancer, responsible for the by far highest YLL percentage and deaths percentage, had a ratio of 1.07, which indicate that both YLL and mortality are high.


Years of life lost as a measure of cancer burden on a national level.

Brustugun OT, Møller B, Helland A - Br. J. Cancer (2014)

Number of deaths of individual cancer types in Norway in 2012 as a percentage of all cancer deaths (y axis) and total YLL of the same cancer type as a percentage of all cancer-related YLL (x axis). The ratio of YLL (%) to deaths (%) (A) and the ratios (log scale) of YLL (%)/mortality (%) are shown for the 18 most frequent cancers (B).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150272&req=5

fig3: Number of deaths of individual cancer types in Norway in 2012 as a percentage of all cancer deaths (y axis) and total YLL of the same cancer type as a percentage of all cancer-related YLL (x axis). The ratio of YLL (%) to deaths (%) (A) and the ratios (log scale) of YLL (%)/mortality (%) are shown for the 18 most frequent cancers (B).
Mentions: The YLL of each cancer can be expressed as a percentage of the total YLL to cancers, and related to the number of deaths (mortality) of each cancer as a percentage of the total number of deaths of cancer. The results of these calculations indicate the relative difference, that is, the degree of imbalance between the YLL parameters and mortality parameters, and are shown in Figure 3A. For most cancer types, the YLL (%)/mortality (%) ratio is close to 1, but ranged from 0.58 (prostate, low relative YLL) to 1.72 (cervical cancer, high relative YLL) (Figure 3B). Lung cancer, responsible for the by far highest YLL percentage and deaths percentage, had a ratio of 1.07, which indicate that both YLL and mortality are high.

Bottom Line: Lung cancer caused almost as many YLL alone (22.1% of cancer-caused YLL) as colon, prostate and breast cancer combined (23.1%).From 1997 to 2012, cancer-caused YLL as a fraction of all YLL increased from 32.5% to 35.2%, but with major differences among diagnoses.Public health efforts and research funding should be explicitly directed at preventing premature deaths.

View Article: PubMed Central - PubMed

Affiliation: 1] Department of Oncology, Oslo University Hospital-The Norwegian Radium Hospital, Oslo, Norway [2] Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

ABSTRACT

Background: The severity of cancers is often measured in number of deaths. However, number of years of life lost (YLL) may be a more appropriate indicator of impact on society. Here we have calculated the YLL of adult cancers in Norway for the year 2012, as well as for the previous 15-year period.

Methods: Data on age composition, expected remaining years of life, total numbers of deaths and deaths due to cancer were retrieved from the National Census Agency Statistics Norway. YLL were calculated for both sexes aged 25-99 years based on each individual's age at death, and the expected remaining years of life at that age.

Results: Cancer deaths represented 25.8% of all adult deaths in 2012, with a lower fraction of females (28.7% in men and 23.1% in women), whereas cancer represented 35.2% of all YLL, with a higher fraction of females (32.8% in men and 37.8% in women). Females loose on average more life years to cancer than men (14.9 vs 12.7 years). Average YLL varied from 23.7 (cervical cancer) to 7.9 (prostate cancer). Lung cancer caused almost as many YLL alone (22.1% of cancer-caused YLL) as colon, prostate and breast cancer combined (23.1%). From 1997 to 2012, cancer-caused YLL as a fraction of all YLL increased from 32.5% to 35.2%, but with major differences among diagnoses.

Conclusions: Cancer is a major and increasing cause of premature deaths, and YLL may be a more accurate measure than number of deaths. Public health efforts and research funding should be explicitly directed at preventing premature deaths.

Show MeSH
Related in: MedlinePlus