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Schwannoma: an unexpected diagnosis from a breast lump

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ABSTRACT

Schwannomas or neurilemmomas are benign neoplasms of the Schwann cells in neural sheaths. They may arise in any nerve in the body and occur frequently in the head and neck region or extremities. While breast lumps and schwannomas are very common, mammary schwannomas are exceedingly scarce with <30 cases reported in the literature. We describe a case of a breast schwannoma in a 37-year-old female and review the literature surrounding this rare occurrence.

No MeSH data available.


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Spindle cell tumour with palisaded arrangement of nuclei, typical of schwannoma. Cellular (Antoni A) areas alternate with looser myxoid (Antoni B) areas.
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RJU085F3: Spindle cell tumour with palisaded arrangement of nuclei, typical of schwannoma. Cellular (Antoni A) areas alternate with looser myxoid (Antoni B) areas.

Mentions: Our patient underwent an excisional biopsy without a preoperative needle biopsy. A 1.2 × 1.2 × 0.8 cm smooth well-encapsulated nodule was removed in entirety from the breast parenchyma. On bisection, the cut section displayed a pale pink smooth homogeneous appearance. Microscopic evaluation showed an encapsulated spindle cell tumour with prominent nuclear palisading and features typical of a schwannoma (Fig. 3). There was also strong and diffuse positive staining of S-100, favouring the diagnosis of schwannoma (Fig. 4). There was no evidence of malignancy in the specimen.Figure 3:


Schwannoma: an unexpected diagnosis from a breast lump
Spindle cell tumour with palisaded arrangement of nuclei, typical of schwannoma. Cellular (Antoni A) areas alternate with looser myxoid (Antoni B) areas.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150249&req=5

RJU085F3: Spindle cell tumour with palisaded arrangement of nuclei, typical of schwannoma. Cellular (Antoni A) areas alternate with looser myxoid (Antoni B) areas.
Mentions: Our patient underwent an excisional biopsy without a preoperative needle biopsy. A 1.2 × 1.2 × 0.8 cm smooth well-encapsulated nodule was removed in entirety from the breast parenchyma. On bisection, the cut section displayed a pale pink smooth homogeneous appearance. Microscopic evaluation showed an encapsulated spindle cell tumour with prominent nuclear palisading and features typical of a schwannoma (Fig. 3). There was also strong and diffuse positive staining of S-100, favouring the diagnosis of schwannoma (Fig. 4). There was no evidence of malignancy in the specimen.Figure 3:

View Article: PubMed Central - HTML

ABSTRACT

Schwannomas or neurilemmomas are benign neoplasms of the Schwann cells in neural sheaths. They may arise in any nerve in the body and occur frequently in the head and neck region or extremities. While breast lumps and schwannomas are very common, mammary schwannomas are exceedingly scarce with <30 cases reported in the literature. We describe a case of a breast schwannoma in a 37-year-old female and review the literature surrounding this rare occurrence.

No MeSH data available.


Related in: MedlinePlus