Limits...
Genome-wide Association Study for Warner-Bratzler Shear Force and Sensory Traits in Hanwoo (Korean Cattle).

Dang CG, Cho SH, Sharma A, Kim HC, Jeon GJ, Yeon SH, Hong SK, Park BY, Kang HS, Lee SH - Asian-australas. J. Anim. Sci. (2014)

Bottom Line: Significant SNPs associated with Warner-Bratzler (WB) shear force and sensory traits were confirmed for Hanwoo beef (Korean cattle).The SNPs between p = 0.001 and p = 0.0001 thresholds explained 3% to 9% of the phenotypic variance, while the most significant SNPs accounted for 7% to 12% of the phenotypic variance.In conclusion, because WB shear force and sensory evaluation were moderately affected by a few loci and minimally affected by other loci, further studies are required by using a large sample size and high marker density.

View Article: PubMed Central - PubMed

Affiliation: Animal Product Research and Development Division, National Institute of Animal Science, Rural Development Administration, Suwon 441-706, Korea .

ABSTRACT
Significant SNPs associated with Warner-Bratzler (WB) shear force and sensory traits were confirmed for Hanwoo beef (Korean cattle). A Bonferroni-corrected genome-wide significant association (p<1.3×10(-6)) was detected with only one single nucleotide polymorphism (SNP) on chromosome 5 for WB shear force. A slightly higher number of SNPs was significantly (p<0.001) associated with WB shear force than with other sensory traits. Further, 50, 25, 29, and 34 SNPs were significantly associated with WB shear force, tenderness, juiciness, and flavor likeness, respectively. The SNPs between p = 0.001 and p = 0.0001 thresholds explained 3% to 9% of the phenotypic variance, while the most significant SNPs accounted for 7% to 12% of the phenotypic variance. In conclusion, because WB shear force and sensory evaluation were moderately affected by a few loci and minimally affected by other loci, further studies are required by using a large sample size and high marker density.

No MeSH data available.


Related in: MedlinePlus

Association of 38,291 SNPs with the WB shear force. (A) Manhattan plot. (B) Quantile-quantile plot. The red line represents the 95% concentration band under the  hypothesis of no association. The black dot represents the p values of the entire study. SNP, single nucleotide polymorphism; WB, Warner-Bratzler.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4150200&req=5

f1-ajas-27-9-1328: Association of 38,291 SNPs with the WB shear force. (A) Manhattan plot. (B) Quantile-quantile plot. The red line represents the 95% concentration band under the hypothesis of no association. The black dot represents the p values of the entire study. SNP, single nucleotide polymorphism; WB, Warner-Bratzler.

Mentions: The Q-Q plot with p<10−3 for WB shear force and sensory evaluation revealed only minimal deviation from the distribution under the hypothesis (Figure 1; Supplementary Figures S1, S2, and S3: See e-version for supplement.). We calculated the proportion of phenotypic variance explained by the SNPs with a p value of 0.001 (Figure 2; Supplementary Figures S4, S5, and S6: See e-version for supplement.). As shown in Figure 2, each of the SNPs between a threshold of p = 0.001 and p = 0.0001 explained 3% to 9% of the phenotypic variance, which is only a small proportion when compared to the total phenotypic variance. However, the most significant SNPs accounted for 7% to 12% of phenotypic variance, which is a large proportion when compared to the total phenotypic variance.


Genome-wide Association Study for Warner-Bratzler Shear Force and Sensory Traits in Hanwoo (Korean Cattle).

Dang CG, Cho SH, Sharma A, Kim HC, Jeon GJ, Yeon SH, Hong SK, Park BY, Kang HS, Lee SH - Asian-australas. J. Anim. Sci. (2014)

Association of 38,291 SNPs with the WB shear force. (A) Manhattan plot. (B) Quantile-quantile plot. The red line represents the 95% concentration band under the  hypothesis of no association. The black dot represents the p values of the entire study. SNP, single nucleotide polymorphism; WB, Warner-Bratzler.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150200&req=5

f1-ajas-27-9-1328: Association of 38,291 SNPs with the WB shear force. (A) Manhattan plot. (B) Quantile-quantile plot. The red line represents the 95% concentration band under the hypothesis of no association. The black dot represents the p values of the entire study. SNP, single nucleotide polymorphism; WB, Warner-Bratzler.
Mentions: The Q-Q plot with p<10−3 for WB shear force and sensory evaluation revealed only minimal deviation from the distribution under the hypothesis (Figure 1; Supplementary Figures S1, S2, and S3: See e-version for supplement.). We calculated the proportion of phenotypic variance explained by the SNPs with a p value of 0.001 (Figure 2; Supplementary Figures S4, S5, and S6: See e-version for supplement.). As shown in Figure 2, each of the SNPs between a threshold of p = 0.001 and p = 0.0001 explained 3% to 9% of the phenotypic variance, which is only a small proportion when compared to the total phenotypic variance. However, the most significant SNPs accounted for 7% to 12% of phenotypic variance, which is a large proportion when compared to the total phenotypic variance.

Bottom Line: Significant SNPs associated with Warner-Bratzler (WB) shear force and sensory traits were confirmed for Hanwoo beef (Korean cattle).The SNPs between p = 0.001 and p = 0.0001 thresholds explained 3% to 9% of the phenotypic variance, while the most significant SNPs accounted for 7% to 12% of the phenotypic variance.In conclusion, because WB shear force and sensory evaluation were moderately affected by a few loci and minimally affected by other loci, further studies are required by using a large sample size and high marker density.

View Article: PubMed Central - PubMed

Affiliation: Animal Product Research and Development Division, National Institute of Animal Science, Rural Development Administration, Suwon 441-706, Korea .

ABSTRACT
Significant SNPs associated with Warner-Bratzler (WB) shear force and sensory traits were confirmed for Hanwoo beef (Korean cattle). A Bonferroni-corrected genome-wide significant association (p<1.3×10(-6)) was detected with only one single nucleotide polymorphism (SNP) on chromosome 5 for WB shear force. A slightly higher number of SNPs was significantly (p<0.001) associated with WB shear force than with other sensory traits. Further, 50, 25, 29, and 34 SNPs were significantly associated with WB shear force, tenderness, juiciness, and flavor likeness, respectively. The SNPs between p = 0.001 and p = 0.0001 thresholds explained 3% to 9% of the phenotypic variance, while the most significant SNPs accounted for 7% to 12% of the phenotypic variance. In conclusion, because WB shear force and sensory evaluation were moderately affected by a few loci and minimally affected by other loci, further studies are required by using a large sample size and high marker density.

No MeSH data available.


Related in: MedlinePlus