Limits...
Left ventricular diastolic parameters in dilated cardiomypoathy: are we missing out on something?

Kashyap R, Mittal BR, Manohar K, Bhattacharya A, Bahl A - World J Nucl Med (2014)

Bottom Line: Diastolic parameters can also be extracted from this investigation.Diastolic dysfunction can coexist in patients with dilated cardiomyopathy and even in patients with preserved LV EF.Routine evaluation of diastolic function in patients with heart failure can help in elucidation of pathogenesis and management of patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

ABSTRACT
Equilibrium radionuclide ventriculography is an established modality to assess the left ventricular (LV) systolic function in several clinical situations. Diastolic parameters can also be extracted from this investigation. The aim of our study is to assess the diastolic function of the left ventricle in cases of idiopathic dilated cardiomyopathy (IDCM) and ischemic cardiomyopathy, where systolic dysfunction has been considered of prime pathologic significance. We conducted a retrospective analysis of 89 patients who had undergone radionuclide ventriculography at our department with established diagnosis of IDCM in 59 patients and ischemic cardiomyopathy in remaining 30 patients. Peak filling rate (PFR) was assessed. The PFR was significantly lower in both patients with IDCM (median = 1.61 end diastolic volumes [EDV]/s) and ischemic cardiomyopathy (median = 2.005 EDV/s). 33% of the patients with ischemic cardiomyopathy and ejection fraction (EF) >45% had diastolic dysfunction while 25% of patients with IDCM and EF >45% had low PFR. Diastolic dysfunction can coexist in patients with dilated cardiomyopathy and even in patients with preserved LV EF. Routine evaluation of diastolic function in patients with heart failure can help in elucidation of pathogenesis and management of patients.

No MeSH data available.


Related in: MedlinePlus

A Box plot showing the median Peak Filling Rates (PFR) for the two study groups of ischaemic cardiomyopathy (labelled CAD for coronary artery disease) and Idiopathic dilated cardiomyopathy (IDCM)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4150164&req=5

Figure 2: A Box plot showing the median Peak Filling Rates (PFR) for the two study groups of ischaemic cardiomyopathy (labelled CAD for coronary artery disease) and Idiopathic dilated cardiomyopathy (IDCM)

Mentions: The mean and median values for the EF were 40.4% and 39.5%, respectively for patients with ischemic cardiomyopathy and 32.6% and 28%, respectively for patients with IDCM [Figure 1]. The median PFR was 2.005 end diastolic volumes (EDV/s) in the group with ischemic cardiomyopathy while it was 1.61 EDV/s in the group with IDCM [Figure 2]. Nine patients with ischemic cardiomyopathy had an EF value of >45% of whom three patients (33%) had low PFR while in the subgroup with IDCM 12 patients had an EF >45% with 3 (25%) showing reduced PFR.


Left ventricular diastolic parameters in dilated cardiomypoathy: are we missing out on something?

Kashyap R, Mittal BR, Manohar K, Bhattacharya A, Bahl A - World J Nucl Med (2014)

A Box plot showing the median Peak Filling Rates (PFR) for the two study groups of ischaemic cardiomyopathy (labelled CAD for coronary artery disease) and Idiopathic dilated cardiomyopathy (IDCM)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150164&req=5

Figure 2: A Box plot showing the median Peak Filling Rates (PFR) for the two study groups of ischaemic cardiomyopathy (labelled CAD for coronary artery disease) and Idiopathic dilated cardiomyopathy (IDCM)
Mentions: The mean and median values for the EF were 40.4% and 39.5%, respectively for patients with ischemic cardiomyopathy and 32.6% and 28%, respectively for patients with IDCM [Figure 1]. The median PFR was 2.005 end diastolic volumes (EDV/s) in the group with ischemic cardiomyopathy while it was 1.61 EDV/s in the group with IDCM [Figure 2]. Nine patients with ischemic cardiomyopathy had an EF value of >45% of whom three patients (33%) had low PFR while in the subgroup with IDCM 12 patients had an EF >45% with 3 (25%) showing reduced PFR.

Bottom Line: Diastolic parameters can also be extracted from this investigation.Diastolic dysfunction can coexist in patients with dilated cardiomyopathy and even in patients with preserved LV EF.Routine evaluation of diastolic function in patients with heart failure can help in elucidation of pathogenesis and management of patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

ABSTRACT
Equilibrium radionuclide ventriculography is an established modality to assess the left ventricular (LV) systolic function in several clinical situations. Diastolic parameters can also be extracted from this investigation. The aim of our study is to assess the diastolic function of the left ventricle in cases of idiopathic dilated cardiomyopathy (IDCM) and ischemic cardiomyopathy, where systolic dysfunction has been considered of prime pathologic significance. We conducted a retrospective analysis of 89 patients who had undergone radionuclide ventriculography at our department with established diagnosis of IDCM in 59 patients and ischemic cardiomyopathy in remaining 30 patients. Peak filling rate (PFR) was assessed. The PFR was significantly lower in both patients with IDCM (median = 1.61 end diastolic volumes [EDV]/s) and ischemic cardiomyopathy (median = 2.005 EDV/s). 33% of the patients with ischemic cardiomyopathy and ejection fraction (EF) >45% had diastolic dysfunction while 25% of patients with IDCM and EF >45% had low PFR. Diastolic dysfunction can coexist in patients with dilated cardiomyopathy and even in patients with preserved LV EF. Routine evaluation of diastolic function in patients with heart failure can help in elucidation of pathogenesis and management of patients.

No MeSH data available.


Related in: MedlinePlus