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Impact of the point spread function on maximum standardized uptake value measurements in patients with pulmonary cancer.

Gellee S, Page J, Sanghera B, Payoux P, Wagner T - World J Nucl Med (2014)

Bottom Line: SUVmax values were measured on PET-computed tomography (CT) scans reconstructed iteratively with and without PSF (respectively high-definition [HD] and non-HD).HD SUVmax values were significantly higher than non-HD SUVmax.There was excellent correlation between HD and non-HD values.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Toulouse University Hospital, Toulouse 31000, France.

ABSTRACT
Maximum standardized uptake value (SUVmax) from fluorodeoxyglucose (FDG) positron emission tomography (PET) scans is a semi quantitative measure that is increasingly used in the clinical practice for diagnostic and therapeutic response assessment purposes. Technological advances such as the implementation of the point spread function (PSF) in the reconstruction algorithm have led to higher signal to noise ratio and increased spatial resolution. The impact on SUVmax measurements has not been studied in clinical setting. We studied the impact of PSF on SUVmax in 30 consecutive lung cancer patients. SUVmax values were measured on PET-computed tomography (CT) scans reconstructed iteratively with and without PSF (respectively high-definition [HD] and non-HD). HD SUVmax values were significantly higher than non-HD SUVmax. There was excellent correlation between HD and non-HD values. Details of reconstruction and PSF implementation in particular have important consequences on SUV values. Nuclear Medicine physicians and radiologists should be aware of the reconstruction parameters of PET-CT scans when they report or rely on SUV measurements.

No MeSH data available.


Related in: MedlinePlus

Comparison of tumour max SUV with HD and non-HD reconstruction
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Related In: Results  -  Collection

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Figure 1: Comparison of tumour max SUV with HD and non-HD reconstruction

Mentions: Mean HD reconstruction SUVmax measurements were significantly higher than non-HD reconstruction measurements (paired t-test) for tumors [difference in mean = 3.658, P < 0.0001, 95% confidence interval [CI] = 2.650-4.666, Figure 1], nodes (difference in mean = 3.283, P = 0.0009, 95% CI = 1.644-4.921) and metastases (difference in mean = 3.721, P < 0.0001, 95% CI = 2.864-4.578).


Impact of the point spread function on maximum standardized uptake value measurements in patients with pulmonary cancer.

Gellee S, Page J, Sanghera B, Payoux P, Wagner T - World J Nucl Med (2014)

Comparison of tumour max SUV with HD and non-HD reconstruction
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150155&req=5

Figure 1: Comparison of tumour max SUV with HD and non-HD reconstruction
Mentions: Mean HD reconstruction SUVmax measurements were significantly higher than non-HD reconstruction measurements (paired t-test) for tumors [difference in mean = 3.658, P < 0.0001, 95% confidence interval [CI] = 2.650-4.666, Figure 1], nodes (difference in mean = 3.283, P = 0.0009, 95% CI = 1.644-4.921) and metastases (difference in mean = 3.721, P < 0.0001, 95% CI = 2.864-4.578).

Bottom Line: SUVmax values were measured on PET-computed tomography (CT) scans reconstructed iteratively with and without PSF (respectively high-definition [HD] and non-HD).HD SUVmax values were significantly higher than non-HD SUVmax.There was excellent correlation between HD and non-HD values.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Toulouse University Hospital, Toulouse 31000, France.

ABSTRACT
Maximum standardized uptake value (SUVmax) from fluorodeoxyglucose (FDG) positron emission tomography (PET) scans is a semi quantitative measure that is increasingly used in the clinical practice for diagnostic and therapeutic response assessment purposes. Technological advances such as the implementation of the point spread function (PSF) in the reconstruction algorithm have led to higher signal to noise ratio and increased spatial resolution. The impact on SUVmax measurements has not been studied in clinical setting. We studied the impact of PSF on SUVmax in 30 consecutive lung cancer patients. SUVmax values were measured on PET-computed tomography (CT) scans reconstructed iteratively with and without PSF (respectively high-definition [HD] and non-HD). HD SUVmax values were significantly higher than non-HD SUVmax. There was excellent correlation between HD and non-HD values. Details of reconstruction and PSF implementation in particular have important consequences on SUV values. Nuclear Medicine physicians and radiologists should be aware of the reconstruction parameters of PET-CT scans when they report or rely on SUV measurements.

No MeSH data available.


Related in: MedlinePlus