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Prognostic Value of Fluoro-D-glucose Uptake of Primary Tumor and Metastatic Lesions in Advanced Nonsmall Cell Lung Cancer.

Nguyen XC, Nguyen VK, Tran MT, Maurea S, Salvatore M - World J Nucl Med (2014)

Bottom Line: Univariate analysis revealed that overall survival was significantly correlated with sumaxSUV (≥35 vs. <35, P = 0.004), T stage (T4 vs.Median survival time was 14 months for patients with sumaxSUV ≥ 35 compared with 20 months for those with sumaxSUV < 35.A large prospective cohort study is necessary to validate these results.

View Article: PubMed Central - PubMed

Affiliation: Unit of PET/CT and Cyclotron, Choray Hospital, Ho Chi Minh City, Vietnam.

ABSTRACT
To assess the prognostic value of maximum standardized uptake value (maxSUV) of the primary tumor (maxSUVpt), maxSUV of whole-body tumors (maxSUVwb) and sum of maximum standardized uptake value (sumaxSUV) measured by the sum of maxSUVs of the primary tumor, metastatic lymph nodes, and metastatic lesions per each organ on fluoro-D-glucose-positron emission tomography/computed tomography in advanced non-small cell lung cancer (NSCLC). Eighty-three patients (49 male, 34 female) with advanced NSCLC were enrolled. Seventeen patients had Stage IIIA, 21 Stage IIIB, and 45 Stage IV. maxSUVpt, maxSUVwb, sumaxSUV, age, gender, tumor-cell type, T stage, N stage, overall stage, primary tumor size, and specific treatment were analyzed for correlation with overall survival. Median follow-up duration was 13 months. Fifty patients were dead during a median follow-up time of 11 months and 33 patients were alive with a median time of 15 months. Univariate analysis revealed that overall survival was significantly correlated with sumaxSUV (≥35 vs. <35, P = 0.004), T stage (T4 vs. T1-T3, P = 0.025), overall stage (IV vs. III, P = 0.002), gender (male vs. female, P = 0.029) and specific treatment (no vs. yes, P = 0.011). maxSUVpt and maxSUVwb were not correlated with overall survival with P value of 0.139 and 0.168, respectively. Multivariate analysis identified sumaxSUV, T stage, gender, and specific treatment as independent prognostic indicators. Patients with a sumaxSUV of ≥35 were 1.921 times more likely to die than those with a sumaxSUV of < 35 (P = 0.047). Median survival time was 14 months for patients with sumaxSUV ≥ 35 compared with 20 months for those with sumaxSUV < 35. In patients with metastatic NSCLC, sumaxSUV with cut-off of 35 was much more significant for survival prognosis (P = 0.021). sumaxSUV is a new prognostic measure, independent of tumor stage, gender, and specific treatment in advanced NSCLC. sumaxSUV may be better than maxSUVpt and maxSUVwb in prediction of survival. A large prospective cohort study is necessary to validate these results.

No MeSH data available.


Related in: MedlinePlus

Fluoro-D-glucose-positron emission tomography (FDG-PET) images of non-small cell lung cancer with left adrenal metastasis. (a) Maximum intensity projection FDG-PET image. (b) maximum standardized uptake value (maxSUV) of lung primary tumor was 19.5. (c) maxSUV of adrenal metastasis was 17.3. Sum of maxSUV of 36.8 was calculated as sum of maxSUVs of lung primary tumor and left adrenal metastasis
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Figure 1: Fluoro-D-glucose-positron emission tomography (FDG-PET) images of non-small cell lung cancer with left adrenal metastasis. (a) Maximum intensity projection FDG-PET image. (b) maximum standardized uptake value (maxSUV) of lung primary tumor was 19.5. (c) maxSUV of adrenal metastasis was 17.3. Sum of maxSUV of 36.8 was calculated as sum of maxSUVs of lung primary tumor and left adrenal metastasis

Mentions: Overall survival time of the patient was defined as the time between the PET/CT study and death or last follow-up date of patients. For analysis of overall survival, maxSUVpt, maxSUVwb and sumaxSUV were dichotomized into two groups around median values to identify the best discriminatory cut-off value for survival prediction. The univariate analysis was conducted using the Kaplan-Meyer log-rank test. Other prognostic factors, such as age, gender, tumor-cell type, stage of the primary tumor, stage of lymph node metastasis, overall stage, size of the primary tumor, and specific treatment were also assessed in survival analysis. In addition, maxSUVpt, maxSUVwb, sumaxSUV, and size of the primary tumor were separately entered as continuous values in a Cox proportional hazard model to assess their association with overall survival. Interactions among variables with significant effect on the overall survival were evaluated by multivariate analysis using the Cox proportional hazard model. P < 0.05 were considered as significant [Figure 1].


Prognostic Value of Fluoro-D-glucose Uptake of Primary Tumor and Metastatic Lesions in Advanced Nonsmall Cell Lung Cancer.

Nguyen XC, Nguyen VK, Tran MT, Maurea S, Salvatore M - World J Nucl Med (2014)

Fluoro-D-glucose-positron emission tomography (FDG-PET) images of non-small cell lung cancer with left adrenal metastasis. (a) Maximum intensity projection FDG-PET image. (b) maximum standardized uptake value (maxSUV) of lung primary tumor was 19.5. (c) maxSUV of adrenal metastasis was 17.3. Sum of maxSUV of 36.8 was calculated as sum of maxSUVs of lung primary tumor and left adrenal metastasis
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150153&req=5

Figure 1: Fluoro-D-glucose-positron emission tomography (FDG-PET) images of non-small cell lung cancer with left adrenal metastasis. (a) Maximum intensity projection FDG-PET image. (b) maximum standardized uptake value (maxSUV) of lung primary tumor was 19.5. (c) maxSUV of adrenal metastasis was 17.3. Sum of maxSUV of 36.8 was calculated as sum of maxSUVs of lung primary tumor and left adrenal metastasis
Mentions: Overall survival time of the patient was defined as the time between the PET/CT study and death or last follow-up date of patients. For analysis of overall survival, maxSUVpt, maxSUVwb and sumaxSUV were dichotomized into two groups around median values to identify the best discriminatory cut-off value for survival prediction. The univariate analysis was conducted using the Kaplan-Meyer log-rank test. Other prognostic factors, such as age, gender, tumor-cell type, stage of the primary tumor, stage of lymph node metastasis, overall stage, size of the primary tumor, and specific treatment were also assessed in survival analysis. In addition, maxSUVpt, maxSUVwb, sumaxSUV, and size of the primary tumor were separately entered as continuous values in a Cox proportional hazard model to assess their association with overall survival. Interactions among variables with significant effect on the overall survival were evaluated by multivariate analysis using the Cox proportional hazard model. P < 0.05 were considered as significant [Figure 1].

Bottom Line: Univariate analysis revealed that overall survival was significantly correlated with sumaxSUV (≥35 vs. <35, P = 0.004), T stage (T4 vs.Median survival time was 14 months for patients with sumaxSUV ≥ 35 compared with 20 months for those with sumaxSUV < 35.A large prospective cohort study is necessary to validate these results.

View Article: PubMed Central - PubMed

Affiliation: Unit of PET/CT and Cyclotron, Choray Hospital, Ho Chi Minh City, Vietnam.

ABSTRACT
To assess the prognostic value of maximum standardized uptake value (maxSUV) of the primary tumor (maxSUVpt), maxSUV of whole-body tumors (maxSUVwb) and sum of maximum standardized uptake value (sumaxSUV) measured by the sum of maxSUVs of the primary tumor, metastatic lymph nodes, and metastatic lesions per each organ on fluoro-D-glucose-positron emission tomography/computed tomography in advanced non-small cell lung cancer (NSCLC). Eighty-three patients (49 male, 34 female) with advanced NSCLC were enrolled. Seventeen patients had Stage IIIA, 21 Stage IIIB, and 45 Stage IV. maxSUVpt, maxSUVwb, sumaxSUV, age, gender, tumor-cell type, T stage, N stage, overall stage, primary tumor size, and specific treatment were analyzed for correlation with overall survival. Median follow-up duration was 13 months. Fifty patients were dead during a median follow-up time of 11 months and 33 patients were alive with a median time of 15 months. Univariate analysis revealed that overall survival was significantly correlated with sumaxSUV (≥35 vs. <35, P = 0.004), T stage (T4 vs. T1-T3, P = 0.025), overall stage (IV vs. III, P = 0.002), gender (male vs. female, P = 0.029) and specific treatment (no vs. yes, P = 0.011). maxSUVpt and maxSUVwb were not correlated with overall survival with P value of 0.139 and 0.168, respectively. Multivariate analysis identified sumaxSUV, T stage, gender, and specific treatment as independent prognostic indicators. Patients with a sumaxSUV of ≥35 were 1.921 times more likely to die than those with a sumaxSUV of < 35 (P = 0.047). Median survival time was 14 months for patients with sumaxSUV ≥ 35 compared with 20 months for those with sumaxSUV < 35. In patients with metastatic NSCLC, sumaxSUV with cut-off of 35 was much more significant for survival prognosis (P = 0.021). sumaxSUV is a new prognostic measure, independent of tumor stage, gender, and specific treatment in advanced NSCLC. sumaxSUV may be better than maxSUVpt and maxSUVwb in prediction of survival. A large prospective cohort study is necessary to validate these results.

No MeSH data available.


Related in: MedlinePlus