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Prevalence of detecting unknown cerebral metastases in fluorodeoxyglucose positron emission tomography/computed tomography and its potential clinical impact.

Kung BT, Auyong TK, Tong CM - World J Nucl Med (2014)

Bottom Line: The true positive rate was 70.8% (17/24), while the false positive rate of PET/CT was 29.2% (7/24).A total of 57.5% (23/40) patients had change in management after PET/CT.PET/CT demonstrated significant clinical impact by identifying cerebral lesions with mass effect and hence that timely treatment was offered.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Pong Ding Yuen Clinical PET/CT Centre and Nuclear Medicine Unit, Queen Elizabeth Hospital, Jordan, Kowloon, Hong Kong, China.

ABSTRACT
To determine the prevalence of incidental finding of unknown cerebral metastases and explore the clinical impact of detecting unknown brain metastases among individuals underwent whole body fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) with brain included in field of view. A retrospective review of 1876 patients who underwent whole body PET/CT examination in our clinical PET center for oncological evaluation from January 2009 to September 2009 was performed. The total number and prevalence of unknown brain metastases detected by PET/CT were calculated. Patients diagnosed with cerebral metastases by PET/CT were further analyzed via the electronic patient record system for relevant clinical and radiological findings. Positive predictive value of PET/CT for the diagnosis of cerebral metastases was calculated with reference to contrast enhanced magnetic resonance imaging (MRI) or contrast enhanced CT. Of the 1876 subjects, 71 patients (3.8%) were diagnosed with cerebral metastases by PET/CT. 31 patients were already diagnosed with brain metastases before PET/CT. Among the 40 patients with unknown brain metastasis, 24 (60.0%) underwent either MRI (n = 5) or CT (n = 19) after PET/CT, of which 17 patients were confirmed with cerebral metastases. The true positive rate was 70.8% (17/24), while the false positive rate of PET/CT was 29.2% (7/24). Nearly 94.1% (16/17) patients with confirmed cerebral metastases on MRI or CT had subsequent change in management. Among the remaining 16 patients with positive findings of cerebral metastases without further radiological correlation, 43.8% (7/16) patients had change in management after PET/CT. A total of 57.5% (23/40) patients had change in management after PET/CT. The point prevalence of detecting unknown cerebral metastases by PET/CT was 2.1% (40/1876). 94.1% patients with newly diagnosed brain metastases confirmed with either MRI or CT received immediate treatment for cerebral metastasis in this retrospective study. PET/CT demonstrated significant clinical impact by identifying cerebral lesions with mass effect and hence that timely treatment was offered.

No MeSH data available.


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81 year old female with right lower lobe lung cancer. Dedicated brain positron emission tomography/computed tomography series showed FDG avid brain metastasis at right high parietal region, maximum standardized uptake value up to 13.0
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Figure 1: 81 year old female with right lower lobe lung cancer. Dedicated brain positron emission tomography/computed tomography series showed FDG avid brain metastasis at right high parietal region, maximum standardized uptake value up to 13.0

Mentions: In our study, among the 17 patients suffered from cerebral metastases subsequently confirmed with either MRI or CT, 13 patients received additional dedicated 3D brain PET imaging. Currently, routine whole-body 3D image acquisition was widely used for most of the latest PET/CT machine, in contrast to our older-generation PET/CT, which only enabled whole-body 2D image acquisition. In dedicated brain series, patient was instructed to lower their arms so as to avoid artefact from the raised arm position as in routine oncological protocol. It has higher sensitivity with better signal-to-noise ratio and lesion detection performance [Figure 1]. It is worthy to further explore if dedicated brain series should be routinely performed in patients undergo whole body PET/CT examination, particularly in those suffered from bronchogenic carcinoma.


Prevalence of detecting unknown cerebral metastases in fluorodeoxyglucose positron emission tomography/computed tomography and its potential clinical impact.

Kung BT, Auyong TK, Tong CM - World J Nucl Med (2014)

81 year old female with right lower lobe lung cancer. Dedicated brain positron emission tomography/computed tomography series showed FDG avid brain metastasis at right high parietal region, maximum standardized uptake value up to 13.0
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150152&req=5

Figure 1: 81 year old female with right lower lobe lung cancer. Dedicated brain positron emission tomography/computed tomography series showed FDG avid brain metastasis at right high parietal region, maximum standardized uptake value up to 13.0
Mentions: In our study, among the 17 patients suffered from cerebral metastases subsequently confirmed with either MRI or CT, 13 patients received additional dedicated 3D brain PET imaging. Currently, routine whole-body 3D image acquisition was widely used for most of the latest PET/CT machine, in contrast to our older-generation PET/CT, which only enabled whole-body 2D image acquisition. In dedicated brain series, patient was instructed to lower their arms so as to avoid artefact from the raised arm position as in routine oncological protocol. It has higher sensitivity with better signal-to-noise ratio and lesion detection performance [Figure 1]. It is worthy to further explore if dedicated brain series should be routinely performed in patients undergo whole body PET/CT examination, particularly in those suffered from bronchogenic carcinoma.

Bottom Line: The true positive rate was 70.8% (17/24), while the false positive rate of PET/CT was 29.2% (7/24).A total of 57.5% (23/40) patients had change in management after PET/CT.PET/CT demonstrated significant clinical impact by identifying cerebral lesions with mass effect and hence that timely treatment was offered.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Pong Ding Yuen Clinical PET/CT Centre and Nuclear Medicine Unit, Queen Elizabeth Hospital, Jordan, Kowloon, Hong Kong, China.

ABSTRACT
To determine the prevalence of incidental finding of unknown cerebral metastases and explore the clinical impact of detecting unknown brain metastases among individuals underwent whole body fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) with brain included in field of view. A retrospective review of 1876 patients who underwent whole body PET/CT examination in our clinical PET center for oncological evaluation from January 2009 to September 2009 was performed. The total number and prevalence of unknown brain metastases detected by PET/CT were calculated. Patients diagnosed with cerebral metastases by PET/CT were further analyzed via the electronic patient record system for relevant clinical and radiological findings. Positive predictive value of PET/CT for the diagnosis of cerebral metastases was calculated with reference to contrast enhanced magnetic resonance imaging (MRI) or contrast enhanced CT. Of the 1876 subjects, 71 patients (3.8%) were diagnosed with cerebral metastases by PET/CT. 31 patients were already diagnosed with brain metastases before PET/CT. Among the 40 patients with unknown brain metastasis, 24 (60.0%) underwent either MRI (n = 5) or CT (n = 19) after PET/CT, of which 17 patients were confirmed with cerebral metastases. The true positive rate was 70.8% (17/24), while the false positive rate of PET/CT was 29.2% (7/24). Nearly 94.1% (16/17) patients with confirmed cerebral metastases on MRI or CT had subsequent change in management. Among the remaining 16 patients with positive findings of cerebral metastases without further radiological correlation, 43.8% (7/16) patients had change in management after PET/CT. A total of 57.5% (23/40) patients had change in management after PET/CT. The point prevalence of detecting unknown cerebral metastases by PET/CT was 2.1% (40/1876). 94.1% patients with newly diagnosed brain metastases confirmed with either MRI or CT received immediate treatment for cerebral metastasis in this retrospective study. PET/CT demonstrated significant clinical impact by identifying cerebral lesions with mass effect and hence that timely treatment was offered.

No MeSH data available.


Related in: MedlinePlus