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Cypermethrin-induced reproductive toxicity in the rat is prevented by resveratrol.

Sharma P, Huq AU, Singh R - J Hum Reprod Sci (2014)

Bottom Line: Cypermethrin exposure resulted in a significant decrease in weight of testis and epididymis, testicular sperm head counts, sperm motility and live sperm counts and increase in sperm abnormalities.Serum testosterone (T), follicle stimulating hormone (FSH), luteinizing hormone (LH), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), glutathione S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and total protein (TP) content were decreased and lipid peroxidation (LPO) level was increased on cypermethrin exposure.The study concluded that resveratrol ameliorated cypermethrin-induced testicular damage by reducing oxidative stress and by enhancing the level of sex hormones.

View Article: PubMed Central - PubMed

Affiliation: Department of Zoology, Bundelkhand University, Jhansi, Uttar Pradesh, India.

ABSTRACT

Aims: The current study was to assess the protective role of resveratrol in cypermethrin-induced reproductive toxicity in male Wistar rats.

Materials and methods: Rats were exposed to cypermethrin (3.83 mg/kg bw) for 14 days. Pre- and post-treatment of resveratrol (20 mg/kg bw for 14 days) was given to cypermethrin exposed rats. At the end of the experiment, rats were sacrificed, testis and epididymis were removed, sperm characteristics, sex hormones, and various biochemical parameters were studied.

Results: Cypermethrin exposure resulted in a significant decrease in weight of testis and epididymis, testicular sperm head counts, sperm motility and live sperm counts and increase in sperm abnormalities. Serum testosterone (T), follicle stimulating hormone (FSH), luteinizing hormone (LH), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), glutathione S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and total protein (TP) content were decreased and lipid peroxidation (LPO) level was increased on cypermethrin exposure. Pre- and post-treatment of resveratrol increased sperm head counts, sperm motility, live sperm counts, T, FSH, LH, GSH, CAT, SOD, GST, GR, GPx and TP contents and decreased LPO. Treatment with resveratrol alone has improved sperm parameters and testicular antioxidant defence system.

Conclusion: The study concluded that resveratrol ameliorated cypermethrin-induced testicular damage by reducing oxidative stress and by enhancing the level of sex hormones.

No MeSH data available.


Related in: MedlinePlus

Sperm counts in different groups on cypermethrin exposure and resveratrol treatment. a= Control, b= Cypermethrin, c= Post-treatment group, d= Pre-treatment group and e= Resveratrol treatment groups
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Figure 2: Sperm counts in different groups on cypermethrin exposure and resveratrol treatment. a= Control, b= Cypermethrin, c= Post-treatment group, d= Pre-treatment group and e= Resveratrol treatment groups

Mentions: The significant (P < 0.01, 38.90%) decrease in sperm head count was reported in G-B on cypermethrin exposure, where as 6.85% and 6.30% decrease was observed in post- and pre-treatment resveratrol Groups C and D, respectively. The results showed that resveratrol treatment increased the sperm head counts in cypermethrin exposed rats. Treatment of control rats (G-A) with resveratrol (G-E) showed significant (P < 0.01, 7.82%) increase in testicular sperm head count [Table 2 and Figure 2].


Cypermethrin-induced reproductive toxicity in the rat is prevented by resveratrol.

Sharma P, Huq AU, Singh R - J Hum Reprod Sci (2014)

Sperm counts in different groups on cypermethrin exposure and resveratrol treatment. a= Control, b= Cypermethrin, c= Post-treatment group, d= Pre-treatment group and e= Resveratrol treatment groups
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150150&req=5

Figure 2: Sperm counts in different groups on cypermethrin exposure and resveratrol treatment. a= Control, b= Cypermethrin, c= Post-treatment group, d= Pre-treatment group and e= Resveratrol treatment groups
Mentions: The significant (P < 0.01, 38.90%) decrease in sperm head count was reported in G-B on cypermethrin exposure, where as 6.85% and 6.30% decrease was observed in post- and pre-treatment resveratrol Groups C and D, respectively. The results showed that resveratrol treatment increased the sperm head counts in cypermethrin exposed rats. Treatment of control rats (G-A) with resveratrol (G-E) showed significant (P < 0.01, 7.82%) increase in testicular sperm head count [Table 2 and Figure 2].

Bottom Line: Cypermethrin exposure resulted in a significant decrease in weight of testis and epididymis, testicular sperm head counts, sperm motility and live sperm counts and increase in sperm abnormalities.Serum testosterone (T), follicle stimulating hormone (FSH), luteinizing hormone (LH), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), glutathione S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and total protein (TP) content were decreased and lipid peroxidation (LPO) level was increased on cypermethrin exposure.The study concluded that resveratrol ameliorated cypermethrin-induced testicular damage by reducing oxidative stress and by enhancing the level of sex hormones.

View Article: PubMed Central - PubMed

Affiliation: Department of Zoology, Bundelkhand University, Jhansi, Uttar Pradesh, India.

ABSTRACT

Aims: The current study was to assess the protective role of resveratrol in cypermethrin-induced reproductive toxicity in male Wistar rats.

Materials and methods: Rats were exposed to cypermethrin (3.83 mg/kg bw) for 14 days. Pre- and post-treatment of resveratrol (20 mg/kg bw for 14 days) was given to cypermethrin exposed rats. At the end of the experiment, rats were sacrificed, testis and epididymis were removed, sperm characteristics, sex hormones, and various biochemical parameters were studied.

Results: Cypermethrin exposure resulted in a significant decrease in weight of testis and epididymis, testicular sperm head counts, sperm motility and live sperm counts and increase in sperm abnormalities. Serum testosterone (T), follicle stimulating hormone (FSH), luteinizing hormone (LH), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), glutathione S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and total protein (TP) content were decreased and lipid peroxidation (LPO) level was increased on cypermethrin exposure. Pre- and post-treatment of resveratrol increased sperm head counts, sperm motility, live sperm counts, T, FSH, LH, GSH, CAT, SOD, GST, GR, GPx and TP contents and decreased LPO. Treatment with resveratrol alone has improved sperm parameters and testicular antioxidant defence system.

Conclusion: The study concluded that resveratrol ameliorated cypermethrin-induced testicular damage by reducing oxidative stress and by enhancing the level of sex hormones.

No MeSH data available.


Related in: MedlinePlus