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Prevalence of abnormal spermatozoa in tobacco chewing sub-fertile males.

Sunanda P, Panda B, Dash C, Ray PK, Padhy RN, Routray P - J Hum Reprod Sci (2014)

Bottom Line: The aim of the following study is to find out the prevalence of abnormal spermatozoa and associated functional parameters in clinical semen samples of sub-fertile males with the tobacco chewing habit.Sperm counts (odds ratio [OR] =2.2; 95% confidence interval [CI]: 1.5-3.09), motility (OR = 3.2; 95% CI: 2.05-4.9), and normal morphology (OR = 8.4; 95% CI: 4.9-14.6) were significantly affected (P = 0.001) in tobacco chewers than the non-chewing group.Structural defects in head (P = 0.001) and cytoplasmic residues (P = 0.001) were found to be positively correlated with the intensive chewing, but no significant changes were found in anomalies in mid-piece and tail.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynaecology, Center for Human Reproduction, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, Odisha, India.

ABSTRACT

Aim: The aim of the following study is to find out the prevalence of abnormal spermatozoa and associated functional parameters in clinical semen samples of sub-fertile males with the tobacco chewing habit.

Settings and design: Retrospective study was conducted at infertility unit of a tertiary health care center, in a period of 3 years.

Materials and method: Semen of 642 males were analyzed; of them 194 men (30.2%) were tobacco chewers and they were grouped according to their intensity of chewing (<10 and ≥ 10 packets/day). Counts, motility, vitality, and morphology of sperms were analyzed.

Results: In tobacco chewers, 66% of subjects were oligozoospermic, 85% asthenozoospermic and 28% teratozoospermic. Sperm counts (odds ratio [OR] =2.2; 95% confidence interval [CI]: 1.5-3.09), motility (OR = 3.2; 95% CI: 2.05-4.9), and normal morphology (OR = 8.4; 95% CI: 4.9-14.6) were significantly affected (P = 0.001) in tobacco chewers than the non-chewing group. Further, in comparison to the intensity of tobacco chewing, patients with the intensive practice of using ≥10 packets/day had a significant effect on sperm morphology (P = 0.003, OR = 2.7; 95% CI = 1.41-5.08) only. Structural defects in head (P = 0.001) and cytoplasmic residues (P = 0.001) were found to be positively correlated with the intensive chewing, but no significant changes were found in anomalies in mid-piece and tail.

Conclusion: The adverse impact of tobacco chewing on semen parameters was evident even with mild chewers, but with the intensive chewing practice, phenotypes of sperms, mainly defects in the head and cytoplasmic residue were severely affected.

No MeSH data available.


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A pictorial depiction of tobacco smoking and chewing affecting male reproductive physiology in causing infertility
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Figure 3: A pictorial depiction of tobacco smoking and chewing affecting male reproductive physiology in causing infertility

Mentions: Nicotine is absorbed in mouth mucosa 3-4 times faster in chewing cases than smoking. Nicotine levels increase gradually with intensive practice of chewing and residual chemicals remain for a prolonged period than in smoking cases.[36] But, the threshold concentration affecting male reproductive system is yet to be defined. Again the quantity of other chemicals, their specific effects on male reproductive system and pathological concentrations in different individuals is largely unknown. The presence of pesticides, maleic hydrazide, chlordane, dichlorodiphenyl-trichloroethane, dichlorodiphenyldichloroethylene, dieldrin, endrine, heptachlor in smokeless tobacco might be causing these endocrinological disorders and damage of sperm DNA. Carcinogenic compounds in gutkha, khaini and betel with accessories are represented [Table 5].[4] A pictorial depiction of tobacco affecting male reproductive physiology causing infertility is too presented [Figure 3].


Prevalence of abnormal spermatozoa in tobacco chewing sub-fertile males.

Sunanda P, Panda B, Dash C, Ray PK, Padhy RN, Routray P - J Hum Reprod Sci (2014)

A pictorial depiction of tobacco smoking and chewing affecting male reproductive physiology in causing infertility
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150141&req=5

Figure 3: A pictorial depiction of tobacco smoking and chewing affecting male reproductive physiology in causing infertility
Mentions: Nicotine is absorbed in mouth mucosa 3-4 times faster in chewing cases than smoking. Nicotine levels increase gradually with intensive practice of chewing and residual chemicals remain for a prolonged period than in smoking cases.[36] But, the threshold concentration affecting male reproductive system is yet to be defined. Again the quantity of other chemicals, their specific effects on male reproductive system and pathological concentrations in different individuals is largely unknown. The presence of pesticides, maleic hydrazide, chlordane, dichlorodiphenyl-trichloroethane, dichlorodiphenyldichloroethylene, dieldrin, endrine, heptachlor in smokeless tobacco might be causing these endocrinological disorders and damage of sperm DNA. Carcinogenic compounds in gutkha, khaini and betel with accessories are represented [Table 5].[4] A pictorial depiction of tobacco affecting male reproductive physiology causing infertility is too presented [Figure 3].

Bottom Line: The aim of the following study is to find out the prevalence of abnormal spermatozoa and associated functional parameters in clinical semen samples of sub-fertile males with the tobacco chewing habit.Sperm counts (odds ratio [OR] =2.2; 95% confidence interval [CI]: 1.5-3.09), motility (OR = 3.2; 95% CI: 2.05-4.9), and normal morphology (OR = 8.4; 95% CI: 4.9-14.6) were significantly affected (P = 0.001) in tobacco chewers than the non-chewing group.Structural defects in head (P = 0.001) and cytoplasmic residues (P = 0.001) were found to be positively correlated with the intensive chewing, but no significant changes were found in anomalies in mid-piece and tail.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynaecology, Center for Human Reproduction, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, Odisha, India.

ABSTRACT

Aim: The aim of the following study is to find out the prevalence of abnormal spermatozoa and associated functional parameters in clinical semen samples of sub-fertile males with the tobacco chewing habit.

Settings and design: Retrospective study was conducted at infertility unit of a tertiary health care center, in a period of 3 years.

Materials and method: Semen of 642 males were analyzed; of them 194 men (30.2%) were tobacco chewers and they were grouped according to their intensity of chewing (<10 and ≥ 10 packets/day). Counts, motility, vitality, and morphology of sperms were analyzed.

Results: In tobacco chewers, 66% of subjects were oligozoospermic, 85% asthenozoospermic and 28% teratozoospermic. Sperm counts (odds ratio [OR] =2.2; 95% confidence interval [CI]: 1.5-3.09), motility (OR = 3.2; 95% CI: 2.05-4.9), and normal morphology (OR = 8.4; 95% CI: 4.9-14.6) were significantly affected (P = 0.001) in tobacco chewers than the non-chewing group. Further, in comparison to the intensity of tobacco chewing, patients with the intensive practice of using ≥10 packets/day had a significant effect on sperm morphology (P = 0.003, OR = 2.7; 95% CI = 1.41-5.08) only. Structural defects in head (P = 0.001) and cytoplasmic residues (P = 0.001) were found to be positively correlated with the intensive chewing, but no significant changes were found in anomalies in mid-piece and tail.

Conclusion: The adverse impact of tobacco chewing on semen parameters was evident even with mild chewers, but with the intensive chewing practice, phenotypes of sperms, mainly defects in the head and cytoplasmic residue were severely affected.

No MeSH data available.


Related in: MedlinePlus